... unique chemokine-like inflammatory cytokine. MIF is pro-atherogenic, but has a complex function in the ischemic heart with a surprising potential as a local cardioprotective factor in early myocardial ischemia. A recent paper published in Clinical Science by Ruze et al. [ 9 ], now suggests that MIF could...

... 2017 15 05 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chemokine cytokine vascular inflammation...

... to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding...

...Sara Galastri; Elena Zamara; Stefano Milani; Erica Novo; Angela Provenzano; Wanda Delogu; Francesco Vizzutti; Salvatore Sutti; Irene Locatelli; Nadia Navari; Elisa Vivoli; Alessandra Caligiuri; Massimo Pinzani; Emanuele Albano; Maurizio Parola; Fabio Marra Expression of CCL2 (CC chemokine ligand 2...

... by macrophages and other macrophage activation receptors. The study of mice deficient in multiple members of the chemokine family, and their receptors, has shown that chemokines play a critical role in promoting atherosclerotic plaque formation. In the present review, we will discuss novel therapeutic avenues...

...-body deficiency of the chemokine receptor CCR2 (CC chemokine receptor 2) on these diseases. To meet this objective, apoE (apolipoprotein E) −/− mice that were either CCR2 +/+ or CCR2 −/− , were infused with either saline or AngII (1000 ng·kg −1 of body weight·min −1 ) for 28 days via mini-osmotic pumps...

...Aiji Sakamoto; Hatsue Ishibashi-Ueda; Yuka Sugamoto; Takeo Higashikata; Susumu Miyamoto; Masa-aki Kawashiri; Kunimasa Yagi; Tetsuo Konno; Kenshi Hayashi; Noboru Fujino; Hidekazu Ino; Yoshiyu Takeda; Masakazu Yamagishi Although several cytokines and chemokines have been demonstrated to play pivotal...

...Ian SABROE; Timothy J. WILLIAMS; James E. PEASE In the search for new treatments for human inflammatory disease, antagonism of chemokine receptors by small molecules is an attractive goal. Although there are overlapping patterns of expression of chemokine receptors between leucocyte types...