... the heart from DOX-induced myocardial damage. Modulation of mitochondrial dynamics could be a novel therapeutic target in alleviating DOX-induced cytotoxic effects without compromising its anticancer efficacy. Cancer Cardiotoxicity Chemotherapy Doxorubicin Mitochondria Mitochondrial dynamics...

... of cancer treatments. Therefore, numerous preclinical studies demonstrate that inhibition of CYP1B1 protects against chemotherapy-induced cardiotoxicity and prevents chemo- and radio-resistance. Most of these studies have utilized phytochemicals to inhibit CYP1B1. Since phytochemicals have multiple targets...

... inhibition in the progression of cancer-related cachexia and female sex and pre-existing comorbidities as independent risk factors for cardiac abnormalities after cancer treatment. cardiac arrhythmia cardio-oncology cardiotoxicity chemotherapy heart failure PI3Kα The phosphoinositide 3...

... 2020 apoptosis Bim chemotherapy colorectal cancer SPZ1 To identify the molecular mechanism by which SPZ1 inhibits apoptosis, we investigated the downstream effectors of SPZ1 and apoptosis-associated proteins. ERK1/2 serves as an intracellular regulator of tumorigenic capacity...

... of the Biochemical Society 2016 cardio-oncology chemotherapy heart failure Heart disease and cancer are the top two causes of mortality globally, accounting for 46.1% of deaths worldwide [ 1 ]. The incidence is projected to increase by 2030. Despite effective treatments for both aetiologies...

...Robert C. RINTOUL; Tariq SETHI Tumour recurrence following chemotherapy remains a major obstacle to the cure of many cancers. This is exemplified by small-cell lung cancer (SCLC). Host-tumour interactions are central to tumour survival and proliferation. We hypothesized that a factor(s) within...

...D. M. K. Keefe; A. G. Cummins; B. M. Dale; D. Kotasek; T. A. Robb; R. E. Sage 1. Mucositis is a common side-effect of chemotherapy which is difficult to assess except by invasive means such as upper gastrointestinal endoscopy. Differential absorption of mono- and di-saccharides, such as rhamnose...

... pressure in hypertensive individuals, and the results suggest that DLIF may contribute to the increased blood pressure in some of these subjects. 26 4 1989 3 5 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 chemotherapy fluid retention hypertension (Na...

... leukaemia and one patient with chronic myeloid leukaemia before and after chemotherapy. 2. Gas chromatography-mass spectrometry was used to determine plasma [ 15 N]glycine enrichment. Pool sizes and turnover rate constants were estimated from time-decay curves for isotope enrichment. 3. Turnover rate...

... of these compounds, which were released in association with liposomal lipid, in draining lymph nodes. 27 11 1974 © 1975 The Biochemical Society and the Medical Research Society 1975 chemotherapy drug therapy liposomes Clinical Science and Molecular Medicine (1975) 49 99-106. Liposomes...