...R. J. UNWIN; S. J. WALTER; G. GIEBISCH; G. CAPASSO; D. G. SHIRLEY In order to clarify the effects on sodium reabsorption in the loop of Henle of methazolamide (a carbonic anhydrase inhibitor), chlorothiazide and the loop diuretics frusemide and bumetanide, superficial loops were perfused in vivo...

...W. H. Boer; H. A. Koomans; E. J. Dorhout Mees 1. The acute effects of chlorothiazide and bendroflumethiazide on renal Li + clearance ( C Li ) were studied in Na + -restricted healthy humans during maximum water diuresis. 2. Chlorothiazide, which has marked carbonic anhydrase inhibiting activity...

...P. J. O. Manhem; S. A. Clark; W. B. Brown; G. D. Murray; J. I. S. Robertson 1. Chlorothiazide (100 mg/kg body weight) was given by gavage daily to spontaneously hypertensive rats for 4 weeks. Another group of spontaneously hypertensive rats was given only tap water and served as control. 2...

... anti-hypertensive effect. 2. Treatment was begun at 12 weeks of age in groups of eleven to seventeen rats with one of the following drugs: reserpine, chlorothiazide or hydrallazine. Blood pressures were recorded by the tail method under light ether anaesthesia every 2 weeks until the rats were...

...A. S. P. Hua; Priscilla Kincaid-Smith 1. A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0·5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents. 2. Compared with absence of diuretic therapy...