...-density lipoprotein cholesterol was increased ( P < 0.001) during monotherapy with chlorthalidone (100 mg/day) but not during combined chlorthalidone-β-blocker therapy. 3. This tendency was similar in subgroups studied with an inverse sequence of drug administration. In subgroup I A (11 men), a 22...

... was used by itself, and also when combined with chlorthalidone. Plasma renin activity and plasma atenolol concentration were also measured. 2. After the administration of atenolol alone, there was a decrease in mean blood pressure from 131·8 ± sem 2·88 mmHg to 119·0 ± 4·05 mmHg ( P < 0·001), in heart...

...A. Jäättelä; K. Pyörälä 1. A double-blind cross-over evaluation of the anti-hypertensive effect of metoprolol vs placebo was carried out in a series of twenty-three patients with mild or moderate essential hypertension who were receiving 25 mg of chlorthalidone daily as their basic treatment...

... significantly. chlorthalidone clonidine low-sodium diet oxprenolol © 1976 The Biochemical Society and the Medical Research Society 1976 Clinical Science and Molecular Medicine (1976) 51, 6259-626s. Comparison of the effects of pharmacological therapy and a low-sodium diet on mild hypertension B. M...

... after frusemide stimulation [0.42 mmol (140 mg) in 18 h] and 3 h ambulation. Thirdly, renin activity was measured after 5 days of chlorthalidone treatment [0.3 mmol (100 mg)/day] and 3 h ambulation. The last two tests were done with the subjects as out-patients without any dietary regimen. 2. In eleven...

... peripheral resistance, whereas chlorthalidone did not. 4. Symptomless hypokalaemia was the only side effect seen with diuretics. 5. Methyldopa and clonidine reduced heart rate and cardiac index, but not total peripheral resistance. 6. The latter drugs also produced dry mouth, lassitude and drowsiness. ©...