...Guochao Song; Fengyi Weng; Bin Zou; Jing Zhao; Jingyi Jin; Dongming Yan; Kai Huang; Xin Sun; Chenghai Liu; Yiyang Hu; Yue Li; Furong Qiu Cholestasis is a pathophysiologic syndrome with limited therapeutic options. Tauroursodeoxycholic acid (TUDCA) has been employed to treat hepatobiliary disorders...

..., and even to extrahepatic ones. Such versatility is the result of its multiple mechanisms of action. UDCA stabilizes plasma membranes against cytolysis by tensioactive bile acids accumulated in cholestasis. UDCA also halts apoptosis by preventing the formation of mitochondrial pores, membrane recruitment...

... of their alteration in cholestatic hepatopathies. The present review addresses in detail this new information by summarizing a number of recent experimental findings on the structural, functional and regulatory aspects of hepatocellular transporter function in acquired cholestasis. This comprises (i) a short overview...

... developed and occurs during the cholestasis phase. Animals weighing approx. 200 g were subjected to bile-duct ligation and excision or sham operation, as described previously [ 11 – 13 ]. Normal rat chow and tap water were offered ad libitum . Experiments were performed after 11–13 days (cholestasis...

... experimental models of cholestasis. In this review we describe the experimental data generated from this model in our laboratory over a period of years, including application of hepatocyte couplets to the study of cytoskeletal changes within the hepatocyte and mechanisms of hepatoprotection in experimentally...

... and progesterone metabolites were measured by GC-MS, in the serum of 411 healthy pregnant women. Samples were collected after an overnight fast in the final week of each trimester of gestation. Two pregnant women were excluded because of the suspicion of intrahepatic cholestasis of pregnancy (ICP). Cholanaemia...

... in bile duct ligated rats, indicating that the severity of cholestasis is almost identical in both models. 2. Plasma alkaline phosphodiesterase I was increased by only 50–80% while alkaline phosphatase was increased more than threefold after ANIT administration. This is in contrast to an earlier study [S...

...Folkert Kuipers; Rick Havinga; Roel J. Vonk 1. Sulphated glycolithocholic acid (SGLC) causes cholestasis in experimental animals, despite its sulphated form. In the present study, the cholestatic potency and the pharmacokinetics of SGLC were investigated in rats under two conditions...

... 1984 2 7 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 alkaline phosphodiesterase I cholestasis Clinical Science (1984) 67, 647-652 647 Serum alkaline phosphodiesterase I in experimental biliary obstruction in the rat STUART R . SIMPSON, K . RAHMAN A N D...

... 1 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 bile acids biliary tract bilirubin cholestasis external bile drainage Clinical Science (1984) 67,61-68 61 The biliary excretion of sulphated and non-sulphated bile acids and bilirubin in patients...

.... in contrast, the binding of [ 3 H]glycochenodeoxycholate and [ 3 H]glycochenodeoxycholate-3-sulphate were not altered by the severity of the cholestasis. 4. Studies in vitro indicated that the reduction in the binding of [ 14 C]glycocholate in cholestatic liver disease was not due to high concentrations...

... cholestasis gas chromatography—mass spectrometry pruritus Clinical Science (1982) 63,65-73 65 Bile acid profiles of human serum and skin interstitial fluid and their relationship to pruritus studied by gas chromatography-mass spectrometry T . C . B A R T H O L O M E W , J . A . S U M M E R F I E L D , B...

...C. L. Corbett; T. C. Bartholomew; Barbara H. Billing; J. A. Summerfield 1. the apparent renal clearance of intravenously injected [ 14 C]glycocholate and [ 3 H]-chenodeoxycholate-3-sulphate was estimated in 22 patients with cholestasis. the degree of protein binding of the isotopes in serum from...

...L. R. Engelking; S. Barnes; C. A. Dasher; D. C. Naftel; B. I. Hirschowitz 1. The serum bile acid disappearances of tracer doses of [24- 14 C]cholic acid and [1- 14 C]-glycocholic acid were studied in eight normal subjects and 11 patients with chronic liver disease (with or without cholestasis...

... of three enzymes which are often used as alternatives in the assessment of patients with liver disease. alkaline phosphatase cholestasis 5′-nucleotidase γ-glutamyl transferase liver Clinical Science and Molecular Medicine (1977) 52,585-590. Enzyme activities of cells of different types isolated...