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Keywords: cholesterol
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Articles
Clin Sci (Lond) (2024) 138 (4): 137–151.
Published: 14 February 2024
... hypercholesterolemia increases the risk of complications, such as preeclampsia. However, the underlying mechanisms are unclear. Toll-like receptor 4 (TLR4) is a membrane receptor modulated by high cholesterol levels, leading to endothelial dysfunction; but whether excessive hypercholesterolemia in pregnancy activates...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (15): 1131–1143.
Published: 09 August 2023
... of osteoporosis increase with age, creating a significant medical and economic burden globally. The importance of cholesterol levels has been reported in the development of diseases including osteoporosis. It is important to note that key enzymes and molecules involved in cholesterol homeostasis are closely...
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Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
... is implicated in the pathogenesis of many human diseases, including allergy, chronic inflammation and cancer. In this review, we aim to introduce the reader to the field of cholesterol immunometabolism and discuss how both metabolites arising from the pathway and cholesterol homeostasis are able to impact...
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Clin Sci (Lond) (2018) 132 (11): 1135–1153.
Published: 09 June 2018
...Allison B. Reiss; Neal Shah; Dalia Muhieddine; Juan Zhen; Jennifer Yudkevich; Lora J. Kasselman; Joshua DeLeon Dyslipidemia, and specifically elevated low-density lipoprotein (LDL) cholesterol, is one of the most important cardiovascular risk factors. Statins are considered first line therapy...
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Clin Sci (Lond) (2017) 131 (14): 1561–1578.
Published: 30 June 2017
... vascular risk factors–diabetes, hypercholesterolaemia, hypertension and smoking–are implicated as risk factors for VaD. The associations between cholesterol and small vessel disease (SVD), stroke, cognitive impairment and subsequent dementia are complex and as yet not fully understood. Similarly...
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Clin Sci (Lond) (2012) 123 (4): 251–257.
Published: 30 April 2012
... and lactation. After weaning, male offspring were maintained on 20% normal laboratory chow. At 6 months of age, LP offspring showed a significantly greater plaque area ( P <0.05) with increased cholesterol clefts and significantly higher indices of DNA damage compared with controls ( P <0.05...
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Clin Sci (Lond) (2010) 118 (5): 333–339.
Published: 23 November 2009
... our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within the hepatocyte is demonstrably more complex than envisioned by the LDL receptor paradigm...
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Clin Sci (Lond) (2009) 116 (2): 87–98.
Published: 15 December 2008
...Fatiha Tabet; Kerry-Anne Rye Plasma levels of HDL (high-density lipoprotein)-cholesterol are strongly and inversely correlated with atherosclerotic cardiovascular disease. Both clinical and epidemiological studies have reported an inverse and independent association between serum HDL-cholesterol...
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Clin Sci (Lond) (2006) 111 (1): 87–91.
Published: 14 June 2006
...Stefan Agewall; Åsa Hernberg Endothelial function is known to predict cardiovascular disease. The aim of the present study was to examine whether endothelial function in smokers with normal cholesterol levels could be normalized by treatment with 80 mg of atorvastatin in comparison with a control...
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Clin Sci (Lond) (2005) 108 (6): 553–559.
Published: 24 May 2005
...Seung-Ha PARK; Won-Young LEE; Eun-Jung RHEE; Woo-Kyu JEON; Byung-Ik KIM; Seung-Ho RYU; Sun-Woo KIM A new simple criterion for diagnosing metabolic syndrome was proposed in the third report of the NCEP (National Cholesterol Education Program). In the present study, we analysed the association...
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Clin Sci (Lond) (2004) 106 (5): 519–525.
Published: 01 May 2004
...Anneli AMBRING; Peter FRIBERG; Mette AXELSEN; Magdalena LAFFRENZEN; Marja-Riitta TASKINEN; Samar BASU; Mats JOHANSSON Mediterranean-inspired diets have been shown to decrease cholesterol levels in patients with hypercholesterolaemia, who frequently exhibit endothelial dysfunction. The aims...
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Clin Sci (Lond) (2001) 100 (4): 401–404.
Published: 05 March 2001
.... Carefully standardized measures of height, weight, blood pressure, pulse rate, total and high-density lipoprotein cholesterol, and plasma fibrinogen were made. Subjects were grouped according to the degree and pattern of baldness as: no baldness, frontal baldness and vertex baldness. Bald men were older...
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Clin Sci (Lond) (1996) 91 (4): 399–413.
Published: 01 October 1996
...Iftikhar Ul Haq; Lawrence E. Ramsay; David M. Pickin; Wilfred W. Yeo; Peter R. Jackson; John N. Payne 1. Recent outcome trials suggest that lipid-lowering with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors is justifiable on risk-benefit grounds in subjects with serum cholesterol...
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Clin Sci (Lond) (1996) 91 (1): 113–118.
Published: 01 July 1996
... from 32 to 70 years. 2. Thirty-four subjects (18 men and 16 women) with total cholesterol concentrations exceeding 200 mg/dl received either a creatine supplement (5 g of creatine plus 1 g of glucose) or a glucose placebo (6 g of glucose) for 56 days. Creatine and placebo were taken orally four times...
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Clin Sci (Lond) (1996) 90 (4): 261–268.
Published: 01 April 1996
... that hypercholesterolaemia impairs coronary vascular reserve in an intact animal. 2. Domestic swine, maintained on a regular ( n = 9) or a 2% high-cholesterol ( n = 9) diet for 3 months were instrumented with a catheter in the left atrium for microsphere injection, a catheter in the anterior interventricular vein for venous...
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Clin Sci (Lond) (1994) 87 (5): 505–511.
Published: 01 November 1994
... concentration increased in parallel with improving liver function, whereas serum creatinine concentration remained elevated in the majority of patients. Serum α- and β-carotene concentrations remained depressed throughout. 3. Serum vitamin E concentration, corrected for total serum cholesterol concentration...
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Clin Sci (Lond) (1993) 85 (4): 451–454.
Published: 01 October 1993
...A. Hallak; R. Rosenberg; T. Gilat; G. J. Sömjen 1. Polyamines are widely distributed in the body and may have cholesterol-nucleating activity in model bile and human bile. There are only partial and scant data available on the type of polyamines in human bile. 2. In this study methods...
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Clin Sci (Lond) (1993) 85 (3): 269–275.
Published: 01 September 1993
... different depending on genotype determined with a low-density lipoprotein receptor DNA marker ( P = 0.03). There was no significant variation in the reduction of plasma total cholesterol, low-density lipoprotein cholesterol or apolipoprotein B concentrations for alleles of other genes tested. 4. Thus...
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Clin Sci (Lond) (1993) 84 (6): 633–643.
Published: 01 June 1993
... to reversal of antiport inhibition (1-2h). These changes in intracellular pH regulation were not due to alterations in cell cholesterol content. 4. A variety of inhibitors of post-translational processes, such as N-linked glycosylation (tunicamycin), phosphorylation (staurosporine), isoprenylation (farnesol...
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Clin Sci (Lond) (1990) 79 (4): 387–391.
Published: 01 October 1990
... and deformability. However, an increase in the membrane cholesterol/phospholipid ratio was found. 4. The stomatocytic shape transformation of erythrocytes in vitro indicates that amiodarone intercalates in the inner hemileaflet of the lipid bilayer leading to membrane internalization. These results shed light...
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Clin Sci (Lond) (1989) 77 (5): 473–478.
Published: 01 November 1989
..., namely phospholipids, cholesterol and 5′-nucleotidase, into bile in anaesthetized rats receiving saline or taurocholate (0.5 μmol min −1 100 g −1 body weight) with or without protoporphyrin IX infusion (10 or 20 μg min −1 100 g −1 body weight). 2. Protoporphyrin IX induced an impairment of spontaneous...
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Clin Sci (Lond) (1985) 69 (1): 71–79.
Published: 01 July 1985
...A. Reuben; P. N. Maton; G. M. Murphy; R. H. Dowling 1. Biliary lipid secretion rates were measured in non-obese and obese individuals with and without cholesterol gallstones, using a steady-state, amino acid duodenal perfusion method. In addition, biliary lipid secretion rates were measured in five...
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Clin Sci (Lond) (1983) 65 (6): 645–652.
Published: 01 December 1983
... liver lipid in both alcoholic and diabetic patients. Cholesteryl ester levels were raised in both alcoholic and diabetic patients but only diabetic patients had significantly increased free cholesterol and phospholipid levels. Determination of phospholipid/free cholesterol ratios revealed a significant...
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Clin Sci (Lond) (1983) 65 (6): 669–672.
Published: 01 December 1983
...R. S. Elkeles; S. R. Khan; V. Chowdhury; M. B. Swallow 1. Changes in serum triglyceride and high density lipoprotein (HDL) cholesterol after a fatty meal have been studied in smokers and non-smokers. 2. Average serum triglyceride during the study was higher in smokers than in non-smokers. 3. In non...
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Clin Sci (Lond) (1981) 61 (2): 253–256.
Published: 01 August 1981
...S. P. Lee 1. Mice when fed a cholesterol/choline-supplemented diet for 4 weeks developed histologically fatty livers. This lipid overloading was associated with an increase in hepatic concentration of connective tissues. 2. Both histological and biochemical abnormalities regressed on stopping...
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Clin Sci (Lond) (1980) 58 (6): 545–548.
Published: 01 June 1980
...Marta Dubin; S. Erlinger 1. The effect of phalloidin on bile acid, phospholipid and cholesterol secretion into bile was studied in rats with bile fistulae. 2. Phalloidin, when given for 7 days, induced a significant decrease in biliary cholesterol concentration and cholesterol saturation index...
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Clin Sci (Lond) (1980) 58 (5): 419–421.
Published: 01 May 1980
...C. H. Bolton; LYN Jackson; C. J. C. Roberts; M. Hartog 1. Serum and lipoprotein cholesterol and triglycerides were measured before, during and after the administration of glutethimide (500 mg daily) for 21 days to six healthy volunteer subjects. 2. Evidence of enzyme induction was provided...
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Clin Sci (Lond) (1979) 57 (s5): 405s–407s.
Published: 01 December 1979
... and 3 months. 3. Plasma cholesterol (VLDL + LDL-cholesterol) increased during treatment. Plasma total cholesterol increased from 5·49 ± sd 0·94 mmol/l at the beginning to 6·37 ± 1·10 mmol/l at 12 months ( P < 0·01). 4. HDL-cholesterol concentration and the ratio of HDL-cholesterol to total...
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Clin Sci Mol Med (1977) 53 (3): 249–256.
Published: 01 September 1977
.... In these subjects a rise in the proportion of deoxycholic acid was also accompanied by a fall in the proportion of both cholic acid and chenodeoxycholic acid in duodenal bile. 3. The biliary lipid composition and cholesterol saturation was determined before and during the administration of 1·9 mmol (0·75 g...
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Clin Sci Mol Med (1977) 52 (2): 219–222.
Published: 01 February 1977
... Research Society 1977 cholesterol ethanol microsomes liver enzyme induction phenobarbitone triglycerides Clinical Science and Molecular Medicine (1977) 52, 219-222. SHORT COMMUNICATION Accentuation of ethanol-induced fatty liver by phenobarbitone A. R. MARSH,* H. S. FRASER, A. BRECKENRIDGE...
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Clin Sci Mol Med (1976) 51 (s3): 469s–471s.
Published: 01 December 1976
... affinity. 5. There is a circulating factor in the plasma of hypertensive patients which sensitizes arteries to noradrenaline, and this factor may be LDL. © 1976 The Biochemical Society and the Medical Research Society 1976 artery cholesterol hypertension noradrenaline Clinical Science...
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Clin Sci Mol Med (1976) 50 (5): 349–353.
Published: 01 May 1976
...P. N. Durrington; C. J. C. Roberts; Lyn Jackson; R. A. Branch; M. Hartog 1. Phenobarbitone in a dose of 180 mg daily was administered to ten normal subjects for 3 weeks. There was a significant increase in total plasma cholesterol, plasma low-density-lipoprotein cholesterol, plasma low-density...
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Clin Sci Mol Med (1976) 50 (4): 307–310.
Published: 01 April 1976
...C. D. Moutafis; N. B. Myant 1. The specific radioactivity of [ 14 C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [ 14 C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms...
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Clin Sci Mol Med (1975) 49 (6): 617–620.
Published: 01 December 1975
...J. P. Miller; A. Chait; B. Lewis 1. Cholesterol esterification has been studied in the plasma of subjects on diets rich in saturated or polyunsaturated fat. 2. The diet rich in polyunsaturated fat was associated with lower rates of plasma cholesterol esterification in vitro. The data suggest...
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Clin Sci Mol Med (1975) 49 (6): 621–624.
Published: 01 December 1975
...P. J. Nestel; B. Kudchodkar 1. Seven subjects were studied before and after the rate of cholesterol synthesis was altered with drugs or dietary cholesterol. 2. The rate at which plasma free cholesterol was formed from squalene during constant infusions of radioactive mevalonate increased...