... offering an effective dietary means to lower LDL cholesterol concentration. cholesterol absorption cholesterol synthesis low-density lipoprotein (LDL) cholesterol lathosterol proprotein convertase subtilisin/kexin type 9 (PCSK9) sitosterol Proprotein convertase subtilisin/kexin type 9...

... with chronic diarrhoea have idio- pathic bile acid malabsorption [I]. The increased losses of bile acids from the enterohepatic circula- tion activate cholesterol synthesis and lead to enhanced conversion of cholesterol to primary bile acids [2-41. The activities of 3-hydroxy-3- methylglutaryl-coenzyme...

..., and reduced cholesterol absorption efficiency significantly from 28.7% to 23.4%. In accordance, faecal excretion of neutral and particularly endogenous neutral sterols increased (16.7% and 19.7%, respectively), but faecal cholesterol elimination and cholesterol synthesis were only insignificantly increased. 4...

... index and dietary plant sterols were negatively associated with cholesterol absorption, but were unrelated to cholesterol synthesis. 4. Fractional cholesterol absorption was related only to the serum very-low-density triacylglycerol level. It was not associated with the total or low-density lipoprotein...

... rats than in controls. 3. Hepatic cholesterol synthesis rates measured in vivo with 3 H 2 O were significantly reduced in alcohol-fed rats. 4. Hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34) activity was increased and the apparent K m for 3-hydroxymethyl-3-glutaryl-CoA...

... of fatty acid release. 3. Cholesterol synthesis in jejunal mucosa was measured in vitro by the incorporation of [2- 14 C]-acetate into sterols. Addition of cholesterol to the incubation reduced [2- 14 C]acetate incorporation into sterols from 8.7 ± 2.1 (mean ± standard error) to 3.7 ± 1.0 pmol h −1 mg −1...

... cholesterol 7α-mono-oxygenase cholesterol synthesis hydroxymethylglutaryl-CoA reductase plasma cholesterol lipoproteins probucol Clinical Science (198 1) 6 1,6 15-6 19 615 On the mechanism of plasma cholesterol reduction in the rat given probucol S . B A L A S U B R A M A N I A M , D . M. B E I N S...