... Novotný; Michal Pravenec; František Kolář Mitochondria play an essential role in improved cardiac ischaemic tolerance conferred by adaptation to chronic hypoxia. In the present study, we analysed the effects of continuous normobaric hypoxia (CNH) on mitochondrial functions, including the sensitivity...

...J. S. Thompson; W. Sheedy; A. H. Morice 1. We have investigated the effects of inhibition of neutral endopeptidase on the cardiovascular remodelling secondary to chronic hypoxia in rats using a novel neutral endopeptidase inhibitor, SCH 42495. 2. Rats were divided into four groups, two of which...

... lumen diameter 983 μm) was directly compared with that of isolated pulmonary resistance vessels (mean lumen diameter 259 μm) from both normoxic animals and animals exposed to chronic hypoxia. 2. Amlodipine caused a significant relaxation of aorta ( P <0.001). A significant relaxation of large...

... in chronic hypoxic rats. 6. This report suggests that some beneficial factors after chronic hypoxia might play important roles in reducing the damage after renal ischaemia. 1 3 1993 14 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 chronic hypoxia...

...T. K. Rogers; A. G. Stewart; A. H. Morice 1. We have investigated the vasoreactivity of isolated pulmonary resistance vessels of rats after acclimatization to chronic hypoxia in a normobaric, hypoxic chamber. Vasoconstriction, in response to KCl and prostaglandin F 2α , and vasodilatation...

...Bernadette Raffestin; Serge Adnot; Jean Jacques Mercadier; Micheline Levame; Philippe Duc; Pierre Braquet; Isabelle Viossat; Pierre Etienne Chabrier 1. To investigate the mechanisms leading to enhanced synthesis and release of atrial natriuretic factor during chronic hypoxia, we measured...

... effect was undiminished. 27 4 1989 4 5 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 chronic hypoxia ligustrazine pulmonary hypertension pulmonary vasodilatation Clinical Science ( 1989) 77.5 15-520 515 Effect of ligustrazine on pulmonary vascular...

... vessels is not reduced, does not suggest a large reduction in the vascular bed in chronic hypoxia. 3. A greater vasodilator action of isoprenaline and adenosine in chronically hypoxic than control lungs suggested a higher normoxic vascular tone. This higher tone was not the sole cause of increased...