... on behalf of the Biochemical Society 2022 Chronic inflammation Galectin-3 Liver fibrosis Macrophages Nonalcoholic fatty liver disease Osteopontin Nonalcoholic steatohepatitis (NASH) is now becoming one of the most common cause of end-stage liver disease in Western countries with a death...

... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...

...-alcoholic steatohepatitis). chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease 1 These authors equally contributed to this work. Statistical analyses were performed using SPSS statistical software using one-way ANOVA test...

... with a FOXO1 inhibitor, an antioxidant that inhibits FOXO1 or IL-1 receptor antagonist alleviates chronic inflammation and insulin resistance in high-fat diet (HFD)-fed mice. Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious...

... with coronary artery disease (CAD). In conclusion, circulating TLR4-responsive miRNAs may be involved in the pathogenesis of CAD. angiotensin-converting enzyme blockade angiotensin II receptor blocker atherosclerosis chronic inflammation cytokine • Our previous reports have demonstrated...

...Mamoru Satoh; Tsuyoshi Tabuchi; Tomonori Itoh; Motoyuki Nakamura The NLRP-3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome has recently emerged as a pivotal regulator of chronic inflammation. The aim of the present study was to determine whether...