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Keywords: chronic kidney disease
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Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney disease (CKD), but the molecular mechanisms underlying this protective process and whether kallistatin plays an endogenous role are incompletely understood. In the present study, we observed that renal...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
... negative regulators of TGF-β1 pathway exacerbates renal lesion formation and discusses the therapeutic value in restoring the expression of these molecules in ameliorating fibrosis, thus, presenting novel approaches to suppress TGF-β1 hyperactivation during chronic kidney disease (CKD) progression...
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... inhibitors and tight control of serum phosphate levels. The coordinated hormonal regulation of serum phosphate involves fibroblast growth factor 23 (FGF23), αKlotho, parathyroid hormone (PTH) and calcitriol. A severe derangement of phosphate homeostasis is observed in patients with chronic kidney disease...
Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... model of unilateral ureteral obstruction (UUO) and an AKI-to-chronic kidney disease (CKD) transition model of unilateral ischemia–reperfusion injury (UIRI), and dissected the underlying renoprotective mechanisms using rat tubular epithelial cells. PAR-1 is activated mostly in the renal tubules in both...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (20): 2755–2769.
Published: 30 October 2020
... 2020 cardiorenal syndrome chronic kidney disease heart failure nitric oxide Patients with heart failure (HF) frequently develop secondary kidney impairment leading to a vicious cycle injurious to both the heart and the kidney. The presence of concomitant kidney impairment in the setting...
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
Published: 16 June 2020
...Uwe Querfeld; Robert H. Mak; Axel Radlach Pries Chronic kidney disease (CKD) is a relentlessly progressive disease with a very high mortality mainly due to cardiovascular complications. Endothelial dysfunction is well documented in CKD and permanent loss of endothelial homeostasis leads to...
Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
...–aldosterone system can slow the progression to end-stage kidney disease (ESKD). Clinical trials for treatments in preventing chronic kidney disease have largely been negative over the last two decades until recent trials have shown positive cardiovascular and renal outcomes of sodium–glucose co-transporter-2...
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
.... † Both authors share senior authorship. 05 08 2019 03 12 2019 20 12 2019 20 12 2019 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 chronic kidney disease CKD-MBD FGF23 inflammation Klotho phosphorus...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (17): 1857–1870.
Published: 10 September 2019
...Siqi Wang; Dan Lv; Shuanghong Jiang; Jianpin Jiang; Min Liang; Fanfan Hou; Ye Chen Chronic kidney disease (CKD) affects 10–15% of the population worldwide, results in high morbidity and mortality, and requires costly treatment and renal replacement therapy. Glomerulosclerosis, tubulointerstitial...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
...Pacific Huynh; Zhonglin Chai The incidence of chronic kidney diseases (CKDs) is expected to rise, fuelled by the ever increasing epidemic of Type 2 diabetes. Despite extensive research in this area, there are currently no effective treatments available to sufficiently halt the progression of CKD...
Clin Sci (Lond) (2018) 132 (19): 2121–2133.
Published: 05 October 2018
.... acute kidney injury chronic kidney disease progression prediction urinary angiotensinogen Survivors of acute kidney injury (AKI) have a markedly increased risk for chronic kidney disease (CKD) [ 1 ]. However, not all AKI survivors are at equal risk of CKD transition [ 2–4 ]. After an AKI...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (5): 509–522.
Published: 09 March 2018
...Wei Ling Lau; Javad Savoj; Michael B. Nakata; Nosratola D. Vaziri In chronic kidney disease (CKD), influx of urea and other retained toxins exerts a change in the gut microbiome. There is decreased number of beneficial bacteria that produce short-chain fatty acids, an essential nutrient for the...
Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
... between stages of chronic kidney disease and serum levels of 10 proteases found that only angiotensin-converting enzyme 2 and DPP-4 activities significantly correlated with estimated glomerular filtration rate (eGFR); in both cases, the relationship was inverse such that patients with the highest DPP-4...
Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
...Alison H.M. Taylor; Alastair J. Rankin; Emily P. McQuarrie; E. Marie Freel; Natalie Z.M. Homer; Ruth Andrew; Alan G. Jardine; Patrick B. Mark Background: Hypertension is prevalent in chronic kidney disease (CKD). Studies suggest that reduction in dietary salt intake reduces blood pressure (BP). We...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics...
Clin Sci (Lond) (2017) 131 (15): 1815–1829.
Published: 05 July 2017
... urine of 62.5% of patients with diabetic kidney disease (DKD), 20.0% of patients with non-diabetic chronic kidney disease (CKD), and no DM patients with normal renal function or healthy control participants; a finding replicated in a larger cohort of 84 patients with CKD in a case–control study (35 with...
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
...Anna Witasp; Amaryllis H. Van Craenenbroeck; Paul G. Shiels; Tomas J. Ekström; Peter Stenvinkel; Louise Nordfors Chronic kidney disease (CKD), affecting 10–12% of the world’s adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature...
Clin Sci (Lond) (2017) 131 (14): 1617–1629.
Published: 30 June 2017
...Maria Dolores Sanchez-Niño; Ana B. Sanz; Adrian M. Ramos; Marta Ruiz-Ortega; Alberto Ortiz The KDIGO definition of chronic kidney disease (CKD) allowed a more detailed characterization of CKD causes, epidemiology and consequences. The picture that has emerged is worrisome from the point of view of...
Clin Sci (Lond) (2017) 131 (13): 1495–1498.
Published: 28 June 2017
...Eve Miller-Hodges; Neeraj Dhaun Chronic kidney disease (CKD) is common, its prevalence increasing with age. Cognitive impairment is common in the elderly, in CKD and in those on maintenance haemodialysis. As cognitive impairment is the precursor to dementia, the identification of reversible risk...
Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
...Aline Silva Miranda; Thiago Macedo Cordeiro; Thomas Mucida dos Santos Lacerda Soares; Rodrigo Novaes Ferreira; Ana Cristina Simões e Silva Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive...
Clin Sci (Lond) (2017) 131 (11): 1069–1092.
Published: 17 May 2017
... pathogenic role of AGEs by focusing on three AGE target organs: kidney, heart and brain. For each of these organs we concentrate on an age-related disease, each of which is a major public health issue: chronic kidney disease, heart dysfunction and neurodegenerative diseases. Even though strong connections...
Clin Sci (Lond) (2017) 131 (3): 225–226.
Published: 05 January 2017
... Cobo G. Hecking M. Port F.K. Exner I. Lindholm B. Stenvinkel P. Carrero J.J. Sex and gender differences in chronic kidney disease: progression to end-stage renal disease and haemodialysis Clin. Sci. (Lond.) 2016 130 1147 1163 10.1042/CS20160047 27252402 7...
Clin Sci (Lond) (2017) 131 (1): 3–12.
Published: 21 November 2016
... both direct and indirect toxicities of urea, which probably promote the premature aging phenotype that is pervasive in chronic kidney disease (CKD). Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation of...
Clin Sci (Lond) (2016) 130 (5): 349–363.
Published: 26 January 2016
... undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway...
Clin Sci (Lond) (2015) 129 (12): 989–999.
Published: 18 September 2015
... othman.al-sawaf@rwth-aachen.de ) or Dr Christoph J. Wruck (email cwruck@ukaachen.de ). 18 6 2015 13 8 2015 13 8 2015 © 2015 Authors; published by Portland Press Limited 2015 cardiovascular disease chronic kidney disease clinical trials multiple sclerosis Nrf2 oxidative...
Clin Sci (Lond) (2013) 125 (5): 237–245.
Published: 07 May 2013
...Ashish Patidar; Dhruv K. Singh; Peter Winocour; Ken Farrington; Anwar R. Baydoun Vascular calcification (VC) strongly correlates with declining renal function and contributes to the high morbidity and mortality of patients with CKD (chronic kidney disease). It is closely regulated by circulating...
Clin Sci (Lond) (2013) 125 (4): 199–210.
Published: 01 May 2013
...Sandra Villanueva; Juan E. Carreño; Lorena Salazar; César Vergara; Rocío Strodthoff; Francisca Fajre; Carlos Céspedes; Pablo J. Sáez; Carlos Irarrázabal; Jorge Bartolucci; Fernando Figueroa; Carlos P. Vio Therapeutic approaches for CKD (chronic kidney disease) have been able to reduce proteinuria...
Clin Sci (Lond) (2011) 121 (11): 489–499.
Published: 09 August 2011
...Sandra Villanueva; Ernesto Ewertz; Flavio Carrión; Andrés Tapia; César Vergara; Carlos Céspedes; Pablo J. Sáez; Patricia Luz; Carlos Irarrázabal; Juan E. Carreño; Fernando Figueroa; Carlos P. Vio CKD (chronic kidney disease) has become a public health problem. The therapeutic approaches have been...
Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
... homoeostasis, cell proliferation, inflammation, reproduction and renoprotection. A large body of research over the past decade has revealed that, in addition to their insulin-sensitizing effects, TZDs play an important role in delaying and preventing the progression of chronic kidney disease in Type 2 diabetes...
Clin Sci (Lond) (2006) 110 (1): 101–108.
Published: 12 December 2005
...Peter Lacy; Susan J. Carr; David O'Brien; Barbara Fentum; Bryan Williams; Sanjoy K. Paul; Thompson G. Robinson Small uncontrolled studies of dialysis-dependent CKD (chronic kidney disease) patients have demonstrated abnormalities of cardiovascular autonomic control and vascular compliance, which...