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Keywords: chronic kidney disease
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Clin Sci (Lond) (2023) 137 (24): 1805–1821.
Published: 21 December 2023
... and of regenerative potential. As the aging population grows, it is crucial to understand the mechanisms underlying these changes, as they increase the susceptibility to developing acute kidney injury (AKI) and chronic kidney disease (CKD). Various cellular processes and molecular pathways take part in the complex...
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Clin Sci (Lond) (2023) 137 (20): 1563–1575.
Published: 17 October 2023
...Hannah Craven; Helen Erlandsson; Dagmara McGuinness; David H. McGuinness; Denise Mafra; Umer Zeeshan Ijaz; Peter Bergman; Paul G. Shiels; Peter Stenvinkel Dialysis and kidney transplantation (Ktx) mitigate some of the physiological deficits in chronic kidney disease (CKD), but it remains...
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Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
...Eva Maria Pastor Arroyo; Nima Yassini; Elif Sakiri; Giancarlo Russo; Soline Bourgeois; Nilufar Mohebbi; Kerstin Amann; Nicole Joller; Carsten A. Wagner; Pedro Henrique Imenez Silva Chronic kidney disease (CKD) affects approximately 10–13% of the population worldwide and halting its progression...
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Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
...Maria V. Irazabal; Alejandro R. Chade; Alfonso Eirin Chronic kidney disease (CKD) is a public health concern that affects over 200 million people worldwide and is associated with a tremendous economic burden. Therefore, deciphering the mechanisms underpinning CKD is crucial to decelerate its...
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Clin Sci (Lond) (2022) 136 (1): 103–120.
Published: 07 January 2022
...Yong Wu; Huan Yang; Sujuan Xu; Ming Cheng; Jie Gu; Weichen Zhang; Shaojun Liu; Minmin Zhang Inflammatory response and renal fibrosis are the hallmarks of chronic kidney disease (CKD). However, the specific mechanism of aldosterone-induced renal injury in the progress of CKD requires elucidation...
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Clin Sci (Lond) (2021) 135 (20): 2393–2408.
Published: 22 October 2021
... activation leads to a polycystic kidney phenotype, suggesting dysregulated AMPK signalling is a contributing factor in cystogenesis. AMPK chronic kidney disease metabolic regulation Kidneys were analysed for cAMP content using a commercial cAMP assay kit (Abcam, ab65355). The concentration...
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Clin Sci (Lond) (2021) 135 (17): 2127–2142.
Published: 10 September 2021
..., U.S.A.). chronic kidney disease EphB receptor tyrosine kinase Ephrin B ligand ischaemia-reperfusion injury renal fibrosis Chronic kidney disease (CKD) is characterized by persistent inflammation and a gradual increase in fibrosis including glomerulosclerosis and tubulointerstitial...
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Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...@juntendo.ac.jp ) * These authors contributed equally to this work. 21 11 2020 12 08 2021 17 08 2021 17 08 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 chronic kidney disease inflammation interleukin-1 renin...
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Clin Sci (Lond) (2021) 135 (16): 1999–2029.
Published: 24 August 2021
...Sandra Rayego-Mateos; Sofia Campillo; Raúl R. Rodrigues-Diez; Antonio Tejera-Muñoz; Laura Marquez-Exposito; Roel Goldschmeding; Diego Rodríguez-Puyol; Laura Calleros; Marta Ruiz-Ortega Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular matrix (ECM) proteins...
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Clin Sci (Lond) (2021) 135 (15): 1915–1927.
Published: 10 August 2021
... kidney disease. © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ageing calciprotein particles chronic kidney disease...
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Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
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Clin Sci (Lond) (2021) 135 (3): 429–446.
Published: 01 February 2021
... progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney disease (CKD), but the molecular mechanisms underlying this protective process and whether kallistatin plays an endogenous role are incompletely understood. In the present study, we observed that renal...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (2): 275–303.
Published: 22 January 2021
... of these negative regulators of TGF-β1 pathway exacerbates renal lesion formation and discusses the therapeutic value in restoring the expression of these molecules in ameliorating fibrosis, thus, presenting novel approaches to suppress TGF-β1 hyperactivation during chronic kidney disease (CKD) progression...
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Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... inhibitors and tight control of serum phosphate levels. The coordinated hormonal regulation of serum phosphate involves fibroblast growth factor 23 (FGF23), αKlotho, parathyroid hormone (PTH) and calcitriol. A severe derangement of phosphate homeostasis is observed in patients with chronic kidney disease...
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Clin Sci (Lond) (2020) 134 (21): 2873–2891.
Published: 13 November 2020
... of unilateral ureteral obstruction (UUO) and an AKI-to-chronic kidney disease (CKD) transition model of unilateral ischemia–reperfusion injury (UIRI), and dissected the underlying renoprotective mechanisms using rat tubular epithelial cells. PAR-1 is activated mostly in the renal tubules in both the UUO...
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Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
...–aldosterone system can slow the progression to end-stage kidney disease (ESKD). Clinical trials for treatments in preventing chronic kidney disease have largely been negative over the last two decades until recent trials have shown positive cardiovascular and renal outcomes of sodium–glucose co-transporter-2...
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Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
... 12 02 2018 13 02 2018 © 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chronic kidney disease dipeptidyl peptidase- 4...
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Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics...
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Clin Sci (Lond) (2017) 131 (15): 1815–1829.
Published: 05 July 2017
...) in the urine of 62.5% of patients with diabetic kidney disease (DKD), 20.0% of patients with non-diabetic chronic kidney disease (CKD), and no DM patients with normal renal function or healthy control participants; a finding replicated in a larger cohort of 84 patients with CKD in a case–control study (35...
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Clin Sci (Lond) (2017) 131 (14): 1617–1629.
Published: 30 June 2017
...Maria Dolores Sanchez-Niño; Ana B. Sanz; Adrian M. Ramos; Marta Ruiz-Ortega; Alberto Ortiz The KDIGO definition of chronic kidney disease (CKD) allowed a more detailed characterization of CKD causes, epidemiology and consequences. The picture that has emerged is worrisome from the point of view...
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Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
...Anna Witasp; Amaryllis H. Van Craenenbroeck; Paul G. Shiels; Tomas J. Ekström; Peter Stenvinkel; Louise Nordfors Chronic kidney disease (CKD), affecting 10–12% of the world’s adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature...
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Clin Sci (Lond) (2017) 131 (13): 1495–1498.
Published: 28 June 2017
...Eve Miller-Hodges; Neeraj Dhaun Chronic kidney disease (CKD) is common, its prevalence increasing with age. Cognitive impairment is common in the elderly, in CKD and in those on maintenance haemodialysis. As cognitive impairment is the precursor to dementia, the identification of reversible risk...
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Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
...Aline Silva Miranda; Thiago Macedo Cordeiro; Thomas Mucida dos Santos Lacerda Soares; Rodrigo Novaes Ferreira; Ana Cristina Simões e Silva Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive...
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Clin Sci (Lond) (2017) 131 (11): 1069–1092.
Published: 17 May 2017
... on the pathogenic role of AGEs by focusing on three AGE target organs: kidney, heart and brain. For each of these organs we concentrate on an age-related disease, each of which is a major public health issue: chronic kidney disease, heart dysfunction and neurodegenerative diseases. Even though strong connections...
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Clin Sci (Lond) (2017) 131 (3): 225–226.
Published: 05 January 2017
... kidney disease cardiovascular disease fibrosis translational science Chronic kidney disease (CKD) is characterized by persisting renal damage and/or loss of renal function. The condition is associated with high morbidity and mortality throughout the continuum from early disease to advanced...
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Clin Sci (Lond) (2017) 131 (1): 3–12.
Published: 21 November 2016
... both direct and indirect toxicities of urea, which probably promote the premature aging phenotype that is pervasive in chronic kidney disease (CKD). Elevated urea at concentrations typically encountered in uremic patients induces disintegration of the gut epithelial barrier, leading to translocation...
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Clin Sci (Lond) (2015) 129 (12): 989–999.
Published: 18 September 2015
... othman.al-sawaf@rwth-aachen.de ) or Dr Christoph J. Wruck (email cwruck@ukaachen.de ). 18 6 2015 13 8 2015 13 8 2015 © 2015 Authors; published by Portland Press Limited 2015 cardiovascular disease chronic kidney disease clinical trials multiple sclerosis Nrf2 oxidative...
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Clin Sci (Lond) (2011) 121 (11): 489–499.
Published: 09 August 2011
...Sandra Villanueva; Ernesto Ewertz; Flavio Carrión; Andrés Tapia; César Vergara; Carlos Céspedes; Pablo J. Sáez; Patricia Luz; Carlos Irarrázabal; Juan E. Carreño; Fernando Figueroa; Carlos P. Vio CKD (chronic kidney disease) has become a public health problem. The therapeutic approaches have been...
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Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
... homoeostasis, cell proliferation, inflammation, reproduction and renoprotection. A large body of research over the past decade has revealed that, in addition to their insulin-sensitizing effects, TZDs play an important role in delaying and preventing the progression of chronic kidney disease in Type 2 diabetes...
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