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1-22 of 22
Keywords: chronic obstructive pulmonary disease
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Articles
Prem Bhattarai, Wenying Lu, Ashutosh Hardikar, Archana Vijay Gaikwad, Surajit Dey, Affan Mahmood Shahzad, Stephen Myers, Andrew Williams, Darren Sutherland, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew S. Eapen, Sukhwinder Singh Sohal
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (17): 1055–1070.
Published: 28 August 2024
... and active endothelial-to-mesenchymal transition (EndMT) in smokers and patients with early chronic obstructive pulmonary disease (COPD). In the present study, we aimed to evaluate the role of different drivers of EndMT. Immunohistochemical staining for EndMT drivers, TGF-β1, pSMAD-2/3, SMAD-7, and β-catenin...
Articles
Peter S. Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah J. Durrington, John F. Blaikley
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (11): 895–912.
Published: 14 June 2023
... findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
...Lynne Faherty; Sarah Kenny; Suzanne M. Cloonan Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease characterised by airflow limitation, chronic bronchitis, emphysema and airway remodelling. Cigarette smoke is considered the primary risk factor for the development of COPD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible diseases, that share a number of common causative factors including cigarette smoking. Atherosclerosis drastically impairs blood flow...
Articles
Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2067–2083.
Published: 01 September 2021
...Sudhir Kotnala; Yerin Kim; Charu Rajput; Hymavathi Reddyvari; Sudhir Bolla; Nathaniel T. Marchetti; Beata Kosmider; Karim Bahmed; Umadevi S. Sajjan Dipeptidyl peptidase 4 (DPP4) expression is increased in the lungs of chronic obstructive pulmonary disease (COPD). DPP4 is known to be associated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
...Kurt Brassington; Stavros Selemidis; Steven Bozinovski; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is a disease characterised by persistent airflow limitation that is not fully reversible and is currently the fourth leading cause of death globally. It is now well established...
Articles
Xuhua Yu, Huei Jiunn Seow, Hao Wang, Desiree Anthony, Steven Bozinovski, Lin Lin, Ji-Ming Ye, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (4): 551–564.
Published: 18 February 2019
...Xuhua Yu; Huei Jiunn Seow; Hao Wang; Desiree Anthony; Steven Bozinovski; Lin Lin; Ji-Ming Ye; Ross Vlahos Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established...
Articles
Mathew S. Eapen, Anudeep Kota, Howard Vindin, Kielan D. McAlinden, Dia Xenaki, Brian G. Oliver, Deepak A. Deshpande, Sukhwinder Singh Sohal, Pawan Sharma
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (14): 1615–1627.
Published: 31 July 2018
...Mathew S. Eapen; Anudeep Kota; Howard Vindin; Kielan D. McAlinden; Dia Xenaki; Brian G. Oliver; Deepak A. Deshpande; Sukhwinder Singh Sohal; Pawan Sharma Increased airway smooth muscle (ASM) mass is observed in chronic obstructive pulmonary disease (COPD), which is correlated with disease severity...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (3): 375–379.
Published: 08 February 2018
... in a chronic lung disease condition. We would like to take this further and discuss new insights in this area. chronic obstructive pulmonary disease drug therapy fibrosis infection inflammation Currently in clinical practice, the mainstay of COPD treatment is inhaled corticosteroids (ICS) which...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (10): 1027–1043.
Published: 09 May 2017
... settings. Correspondence: Ian Pavord ( [email protected] ) 18 10 2016 14 12 2016 26 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 airways disease asthma chronic obstructive pulmonary disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (10): 839–841.
Published: 19 April 2016
...Aran Singanayagam; Sebastian L. Johnston Inhaled β 2 -adrenoceptor agonists are a mainstay of therapy for airways diseases and are almost universally prescribed for patients with asthma or chronic obstructive pulmonary disease (COPD). Very few studies have evaluated the efficacy of these commonly...
Articles
Aran Singanayagam, Nicholas Glanville, Ross P. Walton, Julia Aniscenko, Rebecca M. Pearson, James W. Pinkerton, Jay C. Horvat, Philip M. Hansbro, Nathan W. Bartlett, Sebastian L. Johnston
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (3): 245–258.
Published: 08 May 2015
...Aran Singanayagam; Nicholas Glanville; Ross P. Walton; Julia Aniscenko; Rebecca M. Pearson; James W. Pinkerton; Jay C. Horvat; Philip M. Hansbro; Nathan W. Bartlett; Sebastian L. Johnston Viral exacerbations of chronic obstructive pulmonary disease (COPD), commonly caused by rhinovirus (RV...
Includes: Supplementary data
Articles
Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (5): 283–295.
Published: 05 November 2014
...Afroditi K. Boutou; Nicholas S. Hopkinson; Michael I. Polkey Chronic obstructive pulmonary disease (COPD) is a major health problem, with increasing morbidity and mortality. There is a growing literature regarding the extra-pulmonary manifestations of COPD, which can have a significant impact...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (10): 483–493.
Published: 16 July 2013
...Cedric Hubeau; John E. Kubera; Katherine Masek-Hammerman; Cara M. M. Williams Increased systemic and pulmonary levels of IL-6 (interleukin-6) are associated with the severity of exacerbations and decline of lung function in patients with COPD (chronic obstructive pulmonary disease). Whether IL-6...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only...
Articles
Takahiro URUMA, Hiroshi KIMURA, Akira KOJIMA, Kiyoshi HASAKO, Shigeru MASUYAMA, Koichiro TATSUMI, Takayuki KURIYAMA
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (1): 91–101.
Published: 29 November 1999
... was carried out by 13 healthy subjects and 21 patients with chronic obstructive pulmonary disease (COPD) to evaluate the difference in A I as respiratory drive between the two groups in the absence of a respiratory circuit. In patients with COPD, A I responses to minute ventilation, mean inspiratory flow...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (1): 59–62.
Published: 01 January 1997
... with essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 325–329.
Published: 01 March 1993
...C. I. Coe; N. B. Pride 1. We have re-examined the effects of breathing 100% O 2 on airflow resistance in hypoxaemic patients with chronic obstructive pulmonary disease. We measured arterial O 2 saturation with an ear oximeter and total respiratory resistance by imposing forced oscillations...
Articles
Chim C. Lang, Wendy J. Coutie, Allan D. Struthers, D. Paul Dhillon, John H. Winter, Brian J. Lipworth
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 529–533.
Published: 01 November 1992
... for the first time whether plasma levels of brain natriuretic peptide are elevated in chronic obstructive pulmonary disease. Plasma levels of brain natriuretic peptide and atrial natriuretic peptide were therefore measured in 12 patients admitted with acute hypoxaemic chronic obstructive pulmonary disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (2): 213–222.
Published: 01 February 1983
...J. R. Stradling; D. J. Lane 1. Day and night arterial oxygen saturation ( S a o 2 ) has been measured in forty-one patients with chronic obstructive pulmonary disease (COPD), mean FEV 1 0.84 (range 0.4-1.4) litres, and with a range of daytime S a o 2 values of 67-95%. 2. The mean and biggest falls...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1973) 45 (3): 267–279.
Published: 01 September 1973
...V. Ježek; F. Schrijen 1. The circulatory response to supine exercise and to angiotensin infusion was measured in patients with chronic obstructive pulmonary disease (COPD). 2. Left ventricular function assessed from left ventricular end-diastolic pressure (LVEDP)-stroke volume or stroke work...