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1-24 of 24
Keywords: chronic obstructive pulmonary disease (COPD)
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
...Victoria Austin; Peter J. Crack; Steven Bozinovski; Alyson A. Miller; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (10): 829–837.
Published: 10 April 2016
...Chantal Donovan; Huei Jiunn Seow; Jane E. Bourke; Ross Vlahos β 2 -adrenoceptor agonists are the mainstay therapy for patients with asthma but their effectiveness in cigarette smoke (CS)-induced lung disease such as chronic obstructive pulmonary disease (COPD) is limited. In addition...
Includes: Supplementary data
Articles
Thomas M. Conlon, Jörg Bartel, Korbinian Ballweg, Stefanie Günter, Cornelia Prehn, Jan Krumsiek, Silke Meiners, Fabian J. Theis, Jerzy Adamski, Oliver Eickelberg, Ali Önder Yildirim
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
...Thomas M. Conlon; Jörg Bartel; Korbinian Ballweg; Stefanie Günter; Cornelia Prehn; Jan Krumsiek; Silke Meiners; Fabian J. Theis; Jerzy Adamski; Oliver Eickelberg; Ali Önder Yildirim Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, small airway remodelling...
Articles
Wei Gao, Cheng Yuan, Jingying Zhang, Lingling Li, Like Yu, Coen H. Wiegman, Peter J. Barnes, Ian M. Adcock, Mao Huang, Xin Yao
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... Data. bronchial epithelial cells chronic obstructive pulmonary disease (COPD) cytokines klotho protein oxidative stress smoke • Accelerated aging is linked to several chronic inflammatory disorders. The role of various anti-aging molecules in the pathophysiology and disease...
Includes: Supplementary data
Articles
Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J. Jenkins, Gary P. Anderson, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 785–796.
Published: 05 August 2015
...Steven Bozinovski; Huei Jiunn Seow; Sheau Pyng Jamie Chan; Desiree Anthony; Jonathan McQualter; Michelle Hansen; Brendan J. Jenkins; Gary P. Anderson; Ross Vlahos Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 905–921.
Published: 27 March 2015
... myogenesis and acetylation inhibitors) to selectively target muscle weakness and atrophy in severe COPD. atrophy comorbidities chronic obstructive pulmonary disease (COPD) epigenetic regulation limb muscle weakness muscle growth signalling • Limb muscle weakness and decreased muscle...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
...), held in Horsham in 2012, the present review aims to critique the current ‘state-of-the-art’ in the most commonly used in vivo models for respiratory research, focusing on asthma, chronic obstructive pulmonary disease (COPD) and lung fibrosis. We will highlight the strengths and weaknesses of current...
Articles
Coen H. Wiegman, Feng Li, Colin J. Clarke, Elen Jazrawi, Paul Kirkham, Peter J. Barnes, Ian M. Adcock, Kian F. Chung
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (6): 425–440.
Published: 25 November 2013
... to the inflammatory response and emphysema observed in ozone-exposed mice. 1 These authors contributed equally to this work. Correspondence: Dr Coen H. Wiegman (email [email protected] ). chronic obstructive pulmonary disease (COPD) histone deacetylase hypoxia inflammation oxidative...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (4): 253–265.
Published: 14 October 2013
.... acute exacerbations of chronic obstructive pulmonary disease (AECOPD) chronic obstructive pulmonary disease (COPD) emphysema inflammation skeletal muscle wasting smoking COPD (chronic obstructive pulmonary disease) is a major global health problem and has been predicted to become the third...
Articles
Seamus Grundy, Manminder Kaur, Jonathan Plumb, Sophie Reynolds, Simon Hall, David House, Malcolm Begg, David Ray, Dave Singh
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 223–232.
Published: 09 October 2013
.... Additionally, we investigated whether the expression of NFAT was altered within lungs from COPD patients compared with controls. calcium release-activated calcium channel (CRAC channel) CD8 cell chronic obstructive pulmonary disease (COPD) nuclear factor of activated T-cells (NFAT) ORAI1...
Includes: Supplementary data
Articles
Gerrit John, Katrin Kohse, Jürgen Orasche, Ahmed Reda, Jürgen Schnelle-Kreis, Ralf Zimmermann, Otmar Schmid, Oliver Eickelberg, Ali Önder Yildirim
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 207–221.
Published: 09 October 2013
... the original work is properly cited. chronic obstructive pulmonary disease (COPD) inflammation mainstream neutrophil sidestream smoke • Initial inflammatory processes might contribute to COPD pathogenesis at an early stage of smoke exposure, but different animal CS exposure systems have...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 chronic obstructive pulmonary disease (COPD) computed tomography imaging (CT imaging) genome-wide association inflammation remodelling COPD (chronic obstructive pulmonary disease) is an important cause...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
... chronic obstructive pulmonary disease (COPD) renin–angiotensin system skeletal muscle dysfunction COPD (chronic obstructive pulmonary disease) encompasses a range of pathologies, including chronic bronchitis, bronchiolitis, emphysema and pulmonary vascular destruction. It is characterized...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (7): 285–296.
Published: 07 June 2011
... recognition that asthma is likely to be made up of various phenotypes with differing immunological and inflammatory components [ 54 ]. chronic obstructive pulmonary disease (COPD) fixed airflow obstruction incomplete airflow reversibility leucocyte pulmonary inflammation severe asthma Asthma...
Articles
Carol Pridgeon, Laurence Bugeon, Louise Donnelly, Ursula Straschil, Susan J. Tudhope, Peter Fenwick, Jonathan R. Lamb, Peter J. Barnes, Margaret J. Dallman
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... or expansion of Treg cells. CD4 + CD25 + T-cell chronic obstructive pulmonary disease (COPD) cytokine human interleukin-17 (IL-17) lung inflammation The characteristics and functional relationship of Th1 and Th2 cells and their ability to govern selective aspects of adaptive immunity through...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (3): 143–149.
Published: 06 May 2010
... in non-smokers, current smokers and COPD patients Each bars represents the median value. * P <0.05 and ** P <0.01 compared with peripheral airways of non-smokers. bronchoscopic microsampling technique chronic obstructive pulmonary disease (COPD) N ε -(carboxymethyl)lysine (CML...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (2): 75–86.
Published: 20 April 2010
... and granzyme. The role of CD4 T-lymphocytes is less understood in COPD. © The Authors Journal compilation © 2010 Biochemical Society 2010 chronic obstructive pulmonary disease (COPD) inflammation regulatory T-cell regulatory type 1 cell T-helper 17 cell T-lymphocyte progenitors originate...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... Biochemical Society 2010 co-morbidity chronic obstructive pulmonary disease (COPD) exercise lung function oxidative stress smoking COPD (chronic obstructive pulmonary disease) is caused by the inhalation of noxious material, particularly smoke from tobacco or from the burning of biomass...
Articles
Ugo I. Ekeowa, Bibek Gooptu, Didier Belorgey, Peter Hägglöf, Susanna Karlsson-Li, Elena Miranda, Juan Pérez, Ian MacLeod, Heike Kroger, Stefan J. Marciniak, Damian C. Crowther, David A. Lomas
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (12): 837–850.
Published: 14 May 2009
... (email [email protected] ). 22 9 2008 13 11 2008 28 11 2008 α 1 -antitrypsin chronic obstructive pulmonary disease (COPD) endoplasmic reticulum proteolytic cascade serine protease inhibitor serpinopathy α 1 -Antitrypsin is a 394-amino-acid acute-phase serine protease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 493–495.
Published: 12 February 2009
... [email protected] ). 13 11 2008 27 11 2008 27 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease (COPD) dyspnoea endothelin-1 (ET-1) exercise capacity pulmonary hypertension statin So where does...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (6): 497–505.
Published: 12 February 2009
... patients with PH, probably by inhibiting ET-1 synthesis. Correspondence: Professor Nen-Chung Chang (email [email protected] ). 18 6 2008 2 10 2008 3 10 2008 3 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary...
Articles
Arschang Valipour, Martin Schreder, Michael Wolzt, Sleman Saliba, Sonja Kapiotis, Philipp Eickhoff, Otto Chris Burghuber
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (7): 225–232.
Published: 03 September 2008
... to the clinical data. Correspondence: Dr Arschang Valipour (email [email protected] ). 30 10 2007 4 2 2008 29 2 2008 29 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cardiovascular disease chronic obstructive pulmonary disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... mediated by the activities of perforin and granzymes, (ii) FasL (Fas ligand)-induced apoptosis and/or (iii) cytokine and chemokine release. The present review considers the role of these killer cells in COPD. chronic obstructive pulmonary disease (COPD) cytokine lung natural killer cell T-cell...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (1): 43–51.
Published: 01 January 2004
...) is a physiological regulator of erythrocyte production. EPO maintains erythrocyte production by inhibiting Key words: chronic obstructive pulmonary disease (COPD), cytokines, erythropoietin (EPO), hypoxaemia, O2 sensing. Abbreviations: ACE, angiotensin-converting enzyme; COPD, chronic obstructive pulmonary disease...