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Keywords: chronic obstructive pulmonary disease (COPD)
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Articles
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
...Victoria Austin; Peter J. Crack; Steven Bozinovski; Alyson A. Miller; Ross Vlahos Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established...
Articles
Clin Sci (Lond) (2016) 130 (10): 829–837.
Published: 10 April 2016
...Chantal Donovan; Huei Jiunn Seow; Jane E. Bourke; Ross Vlahos β 2 -adrenoceptor agonists are the mainstay therapy for patients with asthma but their effectiveness in cigarette smoke (CS)-induced lung disease such as chronic obstructive pulmonary disease (COPD) is limited. In addition...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (4): 273–287.
Published: 14 January 2016
...Thomas M. Conlon; Jörg Bartel; Korbinian Ballweg; Stefanie Günter; Cornelia Prehn; Jan Krumsiek; Silke Meiners; Fabian J. Theis; Jerzy Adamski; Oliver Eickelberg; Ali Önder Yildirim Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, small airway remodelling and...
Articles
Clin Sci (Lond) (2015) 129 (12): 1011–1023.
Published: 18 September 2015
... evaluated the loss of Klotho in human lungs with COPD and the underlying mechanisms. bronchial epithelial cells chronic obstructive pulmonary disease (COPD) cytokines klotho protein oxidative stress smoke • Accelerated aging is linked to several chronic inflammatory disorders. The role...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (9): 785–796.
Published: 05 August 2015
...Steven Bozinovski; Huei Jiunn Seow; Sheau Pyng Jamie Chan; Desiree Anthony; Jonathan McQualter; Michelle Hansen; Brendan J. Jenkins; Gary P. Anderson; Ross Vlahos Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine...
Articles
Clin Sci (Lond) (2015) 128 (12): 905–921.
Published: 27 March 2015
... miRNAs promoting myogenesis and acetylation inhibitors) to selectively target muscle weakness and atrophy in severe COPD. atrophy comorbidities chronic obstructive pulmonary disease (COPD) epigenetic regulation limb muscle weakness muscle growth signalling • Limb muscle weakness and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (4): 235–256.
Published: 17 October 2014
... mortality across the world. Correspondence : Dr Paul Mercer (email paul.mercer@ucl.ac.uk ). 26 6 2014 3 9 2014 5 9 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 asthma chronic obstructive pulmonary disease (COPD) lung disease pulmonary fibrosis...
Articles
Clin Sci (Lond) (2014) 126 (6): 425–440.
Published: 25 November 2013
.... chronic obstructive pulmonary disease (COPD) histone deacetylase hypoxia inflammation oxidative stress ozone • Oxidative stress is linked to various chronic inflammation disorders. The role of oxidative stress in the aetiology, pathophysiology and disease progression of respiratory...
Articles
Clin Sci (Lond) (2014) 126 (4): 253–265.
Published: 14 October 2013
... exacerbations of chronic obstructive pulmonary disease (AECOPD) chronic obstructive pulmonary disease (COPD) emphysema inflammation skeletal muscle wasting smoking COPD (chronic obstructive pulmonary disease) is a major global health problem and has been predicted to become the third largest cause...
Articles
Clin Sci (Lond) (2014) 126 (3): 223–232.
Published: 09 October 2013
... release-activated calcium channel (CRAC channel) CD8 cell chronic obstructive pulmonary disease (COPD) nuclear factor of activated T-cells (NFAT) ORAI1 • Currently available anti-inflammatory therapies have limited efficacy in COPD and therefore there is a need for novel anti-inflammatory...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (3): 207–221.
Published: 09 October 2013
... Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. chronic obstructive pulmonary disease (COPD) inflammation mainstream neutrophil...
Articles
Clin Sci (Lond) (2013) 124 (6): 371–387.
Published: 27 November 2012
... 6 2012 21 8 2012 27 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 chronic obstructive pulmonary disease (COPD) computed tomography imaging (CT imaging) genome-wide association inflammation remodelling COPD (chronic obstructive pulmonary...
Articles
Clin Sci (Lond) (2012) 123 (8): 487–498.
Published: 27 June 2012
... angiotensin-converting enzyme angiotensin receptor blocker cardiovascular disease chronic obstructive pulmonary disease (COPD) renin–angiotensin system skeletal muscle dysfunction COPD (chronic obstructive pulmonary disease) encompasses a range of pathologies, including chronic bronchitis...
Articles
Clin Sci (Lond) (2011) 121 (7): 285–296.
Published: 07 June 2011
... light on the immunological processes involved. Correspondence: Dr Lucy Fairclough (email lucy.fairclough@nottingham.ac.uk ). 1 2 2011 5 4 2011 5 5 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 chronic obstructive pulmonary disease (COPD...
Articles
Clin Sci (Lond) (2011) 120 (12): 515–524.
Published: 07 March 2011
... expansion of Treg cells. Correspondence: Professor Margaret Dallman (email m.dallman@imperial.ac.uk ). 13 8 2010 30 11 2010 6 1 2011 6 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 CD4 + CD25 + T-cell chronic obstructive pulmonary disease...
Articles
Clin Sci (Lond) (2010) 119 (3): 143–149.
Published: 06 May 2010
... 18 3 2010 18 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 bronchoscopic microsampling technique chronic obstructive pulmonary disease (COPD) N ε -(carboxymethyl)lysine (CML) epithelial lining fluid small airway COPD (chronic obstructive...
Articles
Clin Sci (Lond) (2010) 119 (2): 75–86.
Published: 20 April 2010
... obstructive pulmonary disease (COPD) inflammation regulatory T-cell regulatory type 1 cell T-helper 17 cell COPD (chronic obstructive pulmonary disease) is a major cause of ill-health and mortality, predicted to become the third commonest cause of death worldwide by 2030 [ 1 ]. It is predominantly...
Articles
Clin Sci (Lond) (2010) 118 (9): 565–572.
Published: 09 February 2010
... through spirometry screening. Correspondence: Dr Nicholas S. Hopkinson (email n.hopkinson@ic.ac.uk ). 8 9 2009 28 10 2009 30 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 co-morbidity chronic obstructive pulmonary disease (COPD) exercise...
Articles
Clin Sci (Lond) (2009) 116 (12): 837–850.
Published: 14 May 2009
... A. Lomas (email dal16@cam.ac.uk ). 22 9 2008 13 11 2008 28 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 α 1 -antitrypsin chronic obstructive pulmonary disease (COPD) endoplasmic reticulum proteolytic cascade serine protease inhibitor...
Articles
Clin Sci (Lond) (2009) 116 (6): 493–495.
Published: 12 February 2009
... (email s.wort@imperial.ac.uk ). 13 11 2008 27 11 2008 27 11 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary disease (COPD) dyspnoea endothelin-1 (ET-1) exercise capacity pulmonary hypertension statin COPD...
Articles
Clin Sci (Lond) (2009) 116 (6): 497–505.
Published: 12 February 2009
... patients with PH, probably by inhibiting ET-1 synthesis. Correspondence: Professor Nen-Chung Chang (email ncchang@tmu.edu.tw ). 18 6 2008 2 10 2008 3 10 2008 3 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 chronic obstructive pulmonary...
Articles
Clin Sci (Lond) (2008) 115 (7): 225–232.
Published: 03 September 2008
... pulmonary disease (COPD) C-reactive protein (CRP) systemic inflammation vascular endothelial growth factor VEGF) VEGF (vascular endothelial growth factor), a soluble heparin-binding glycoprotein, is a cytokine with potent angiogenic properties, enhancing vascular permeability and modulating...
Articles
Clin Sci (Lond) (2008) 114 (8): 533–541.
Published: 13 March 2008
... (email lucy.fairclough@nottingham.ac.uk ). 9 10 2007 28 11 2007 13 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 chronic obstructive pulmonary disease (COPD) cytokine lung natural killer cell T-cell receptor T-lymphoycyte COPD is a...
Articles
Clin Sci (Lond) (2004) 106 (1): 43–51.
Published: 01 January 2004
.... Correspondence: Professor Branimir Jaksic (e-mail branimir.jaksic@zg.hinet.hr ). 7 5 2003 11 8 2003 13 8 2003 13 8 2003 © 2004 The Biochemical Society 2004 chronic obstructive pulmonary disease (COPD) cytokines erythropoietin (EPO) hypoxaemia O2 sensing Clinical Science...