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Keyword: cirrhosis
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Clin Sci (Lond) (2019) 133 (6): 741-760.
Published: 19 March 2019
... also important in PBC pathogenesis. Activation of these cells initiates and perpetuates bile duct damage in PBC patients, leading to intrahepatic cholestasis, hepatic damage, liver fibrosis, and eventually cirrhosis or even liver failure. Taken together, the body of accumulated clinical and...
Clin Sci (Lond) (2019) 133 (3): 465-481.
Published: 12 February 2019
... skeletal muscle alteration in CLD. We next describe recent literature on muscle wasting in cirrhosis and liver transplantation. We then discuss the implication of skeletal muscle compartment in non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), focusing on plausible metabolic...
Clin Sci (Lond) (2018) 132 (22): 2391-2405.
Published: 19 November 2018
...I-Fang Hsin; Hui-Chun Huang; Ching-Chih Chang; Shao-Jung Hsu; Fa-Yauh Lee; Teh-Ia Huo; Chiao-Lin Chuang; Ming-Chih Hou; Shou-Dong Lee Liver cirrhosis is accompanied by increased intrahepatic resistance and angiogenesis-related portosystemic collaterals formation. Diabetic patients suffer from...
Clin Sci (Lond) (2018) 132 (12): 1341-1343.
Published: 28 June 2018
...Audrey Payancé; Pierre-Emmanuel Rautou Data on the consequences of cirrhosis regression on portal hypertension and on splanchnic and systemic hemodynamic are scarce. Previous studies have reported a decrease in hepatic venous pressure gradient following antiviral treatment in patients with...
Clin Sci (Lond) (2017) 131 (15): 2059-2062.
Published: 20 July 2017
...@ki.se ) 21 06 2017 30 06 2017 07 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cirrhosis drug-induced liver injury liver fibrosis mouse models The liver fulfills crucial functions in energy homeostasis and...
Clin Sci (Lond) (2012) 123 (12): 669-680.
Published: 10 August 2012
... disarrangement in the hepatic microcirculation. NASH-cirrhosis with hyperleptinaemia was induced in lean rats by feeding with an HF/MCD (high-fat/methionine-choline-deficient) diet. Portal haemodynamics, various substances, protein and mRNA expression and PUFA (polyunsaturated fatty acid) composition were...
Clin Sci (Lond) (2012) 123 (4): 225-239.
Published: 24 April 2012
... the pathophysiology of portal hypertension in cirrhosis. Although the intrahepatic circulation in cirrhosis is hypercontractile in response to AngII, resulting in increased hepatic resistance, the splanchnic vasculature is hyporesponsive, promoting the development of the hyperdynamic circulation that...
Clin Sci (Lond) (2011) 120 (7): 285-286.
Published: 13 December 2010
...Pietro Invernizzi HCV (hepatitis C virus) represents one of the major health problems worldwide, as almost 170 million people are infected and most of these develop a chronic disease, often with the progression to cirrhosis and its complications. In the present issue of Clinical Science , Iwata and...
Clin Sci (Lond) (2011) 120 (7): 287-296.
Published: 13 December 2010
... HCV (hepatitis C virus)-associated cirrhosis represents a major indication for liver transplantation. Bile acids contribute to hepatic stellate cell activation as a key event in fibrogenesis. The aim of the present study was to investigate the role of bile acids and polymorphisms in bile acid level...
Clin Sci (Lond) (2011) 120 (5): 183-193.
Published: 19 November 2010
... serum miRNAs as biomarkers for liver pathologies. Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed to profile miRNAs in serum pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) and from healthy controls. Five miRNAs (i.e. miR - 885 - 5p...
Includes: Supplementary data
Clin Sci (Lond) (2010) 119 (10): 431-436.
Published: 05 August 2010
... hepatitis, n =71; autoimmune disease, n =18; alcohol-induced liver disease, n =3; or elevated liver enzymes of unknown origin, n =31) and 45 with cirrhosis. Circulating adiponectin levels were significantly lower in patients with NAFLD in comparison with patients with other chronic liver disease (4.8±3.5...
Includes: Supplementary data
Clin Sci (Lond) (2010) 119 (7): 283-292.
Published: 25 June 2010
...Fabiano E. Xavier; Javier Blanco-Rivero; Esther Sastre; Lina Badimón; Gloria Balfagón Our present study examines, in mesenteric resistance arteries, possible vasodilation alterations, and the role of NO and COX (cyclo-oxygenase) derivatives, in cirrhosis. The vasodilator response to acetylcholine...
Clin Sci (Lond) (2010) 119 (1): 45-55.
Published: 07 April 2010
... for 1 week on the hepatic microcirculation of cirrhotic rats. Cirrhosis was induced by bile duct ligation with sham-operated rats serving as normal controls. Intrahepatic resistance was evaluated by in situ liver perfusion. Expression of phospho-eNOS (endothelial NO synthase), iNOS (inducible NO...
Clin Sci (Lond) (2009) 117 (11): 375-386.
Published: 14 September 2009
...–angiotensin system) components and the effects of Ang-(1–7) were examined in rat HSCs (hepatic stellate cells). In human patients with cirrhosis, both plasma Ang-(1–7) and AngII concentrations were markedly elevated ( P <0.001). Non-cirrhotic patients with hepatitis C had elevated Ang-(1–7) levels compared...
Includes: Supplementary data
Clin Sci (Lond) (2009) 116 (12): 851-859.
Published: 14 May 2009
...Simonetta Genovesi; Daniela M. Prata Pizzala; Massimo Pozzi; Laura Ratti; Maria Milanese; Federico Pieruzzi; Antonio Vincenti; Andrea Stella; Giuseppe Mancia; Marco Stramba-Badiale A prolongation of QT interval has been shown in patients with cirrhosis and it is considered as part of the definition...
Clin Sci (Lond) (2009) 116 (1): 71-79.
Published: 28 November 2008
...Ying-Ying Yang; Yi-Tsau Huang; Kuei-Chuan Lee; Fa-Yauh Lee; Tzung-Yan Lee; Ming-Chih Hou; Han-Chieh Lin; Shou-Dong Lee Liver cirrhosis is characterized by increased IHR (intrahepatic resistance) and lipid peroxidation, and decreased antioxidative defence. The present study investigates the effects...
Clin Sci (Lond) (2007) 112 (10): 533-542.
Published: 12 April 2007
...Ying-Ying Yang; Han-Chieh Lin; Yi-Tsau Huang; Tzung-Yan Lee; Ming-Chih Hou; Ying-Wen Wang; Fa-Yauh Lee; Shou-Dong Lee Recent studies have shown that the activated endocannabinoid system participates in the increase in IHR (intrahepatic resistance) in cirrhosis. The increased hepatic production of...
Clin Sci (Lond) (2007) 112 (5): 265-280.
Published: 01 February 2007
... cirrhosis collagen fibrosis hepatic stellate cell inflammation liver myofibroblast Fibrosis of the liver and its end stage, cirrhosis, represents a massive health care burden worldwide. Liver disease is increasing in incidence globally. In the West, the main causes of liver fibrosis are...
Clin Sci (Lond) (2007) 112 (3): 141-155.
Published: 03 January 2007
...Ulrich Spengler; Jacob Nattermann HCV (hepatitis C virus) has a high propensity to persist and to cause chronic hepatitis C, eventually leading to cirrhosis. Since HCV itself is not cytopathic, liver damage in chronic hepatitis C is commonly attributed to immune-mediated mechanisms. HCV proteins...
Clin Sci (Lond) (2004) 107 (5): 425-434.
Published: 26 October 2004
...Brindhesha RASARATNAM; Nathan CONNELLY; Jaye CHIN-DUSTING Abnormal vascular tone is responsible for many of the complications seen in cirrhosis making the identification of the pathophysiology of abnormal dilatation a major focus in hepatology research. The study of abnormal vascular tone is...
Clin Sci (Lond) (2004) 106 (1): 27-34.
Published: 01 January 2004
...Pietro PANTALEO; Fabio MARRA; Francesco VIZZUTTI; Saura SPADONI; Giovanni CIABATTONI; Claudio GALLI; Giorgio LA VILLA; Paolo GENTILINI; Giacomo LAFFI Advanced cirrhosis is associated with reduced platelet function and altered renal function and sodium handling. Arachidonic acid (AA) metabolites...
Clin Sci (Lond) (2003) 105 (3): 373-382.
Published: 01 September 2003
... virus-induced end-stage liver cirrhosis and controls. Results were compared with histology, hepatic expression of tissue inhibitor of metalloproteinases (TIMP)-1, -2 and -3, procollagen types I and IV, laminin, and with circulating protein levels of hyaluronate, TIMP-1 and -2 and MMP proenzymes, as...
Clin Sci (Lond) (2003) 105 (1): 1-8.
Published: 01 July 2003
... cirrhosis vasopressin Clinical Science (2003) 105, 1 8 (Printed in Great Britain) 1 R E V I E W Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis James Walter FERGUSON , George THERAPONDOS , David E NEWBY and Peter Clive HAYES Department of Medicine, Royal Infirmary...
Clin Sci (Lond) (2001) 101 (6): 651-657.
Published: 20 November 2001
... facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high- M r kininogen and activation of fibrinolysis, but bradykinin has never been measured directly. In the ascitic fluid of 24 patients with cirrhosis, we measured bradykinin-(1-9)-nonapeptide levels by RIA...
Clin Sci (Lond) (2001) 101 (6): 621-628.
Published: 29 October 2001
...Florence WONG; Samuel SIU; Peter LIU; Laurence M. BLENDIS Subtle cardiac abnormalities have been described in patients with cirrhosis. Natriuretic peptide hormones have been reported to be sensitive markers of early cardiac disease. We postulate that plasma levels of N-terminal pro-atrial...
Clin Sci (Lond) (2000) 99 (2): 159-160.
Published: 17 July 2000
...Giovambattista DESIDERI; Claudio FERRI Correspondence : Dr G Desideri (e-mail gbdesi@freemail.it ). 13 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 chronic hepatitis cirrhosis vascular endothelial growth factor 159Clinical Science (2000...
Clin Sci (Lond) (2000) 98 (4): 419-425.
Published: 08 March 2000
...Sun-Sang WANG; Fa-Yauh LEE; Che-Chang CHAN; Rei-Hwa LU; Yee CHAO; Han-Chieh LIN; Shwu-Ling WU; Yang-Te TSAI; Shou-Dong LEE To delineate the clinical roles of plasma cytokine or endotoxin levels in the natural course of infection in patients with decompensated cirrhosis, 66 cirrhotic patients were...
Clin Sci (Lond) (1999) 97 (3): 313-318.
Published: 21 July 1999
...Dominique PATERON; Frédéric OBERTI; Pascale LEFILLIATRE; Nary VEAL; Khalid A. TAZI; Philippe SOGNI; Odile POIREL; Jörg HELLER; Richard MOREAU; Paul CALES; Didier LEBREC In cirrhosis there is a hyperdynamic circulation, which occurs mainly in the systemic and splanchnic regions. Using isolated...
Clin Sci (Lond) (1999) 97 (3): 259-267.
Published: 15 July 1999
...Florence WONG; Florence WONG; Peter LIU; Lesley LILLY; Arieh BOMZON; Laurence BLENDIS The aim of this study was to assess the relationship between subtle cardiovascular abnormalities and abnormal sodium handling in cirrhosis. A total of 35 biopsy-proven patients with cirrhosis with or without...
Clin Sci (Lond) (1999) 96 (5): 475-481.
Published: 14 April 1999
...Panagiotis VLAVIANOS; Padraik MAC MATHUNA; Roger WILLIAMS; David WESTABY We investigated the haemodynamic response to volume depletion and subsequent repletion in patients with cirrhosis and portal hypertension. Twelve patients with compensated cirrhosis and portal hypertension were included in the...
Clin Sci (Lond) (1999) 96 (5): 467-474.
Published: 25 March 1999
...Florence WONG; Arieh BOMZON; Johane ALLARD; Peter LIU; Laurence BLENDIS Systemic arterial vasodilatation has been implicated in the pathogenesis of sodium retention in cirrhosis. Hydrophobic bile acids, which have vasodilatory actions, may be involved. Ursodeoxycholic acid, a hydrophilic bile acid...
Clin Sci (Lond) (1998) 95 (4): 505-511.
Published: 01 October 1998
...Patrick W. F. HADOKE; John F. DILLON; Timothy G. JOHN; Simon W. WALKER; Peter C. HAYES; Brent C. WILLIAMS 1. Impaired vasoconstriction in animals with cirrhosis is maintained in isolated vessels in vitro , indicating an intrinsic alteration in function or structure of the cells in the vascular wall...
Clin Sci (Lond) (1998) 94 (4): 367-371.
Published: 01 April 1998
... Society and the Medical Research Society 1998 cirrhosis octreotide portal hypertension portal hypertensive gastropathy Clinical Science (1998) 94,367-371 (Printed in Great Britain) 361 Chronic administration of octreotide ameliorates portal hypertension and portal hypertensive gastropathy in...
Clin Sci (Lond) (1997) 93 (3): 219-225.
Published: 01 September 1997
... participate in the development and/or maintenance of hyperdynamic circulation. 24 1 1997 8 5 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 cirrhosis endotoxin hyperdynamic circulation nitric oxide portal hypertension tumour necrosis factor-α Clinical...
Clin Sci (Lond) (1997) 92 (5): 433-443.
Published: 01 May 1997
... may be a treatable precipitant of renal failure in cirrhosis. Renal perfusion should be optimized by ensuring that the blood pressure and systemic haemodynamics are adequate, and that if renal venous pressure is elevated, due to tense ascites, it is alleviated. 4. The prognosis of hepatorenal syndrome...
Clin Sci (Lond) (1997) 92 (1): 59-62.
Published: 01 January 1997
... essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart...
Clin Sci (Lond) (1996) 91 (1): 29-33.
Published: 01 July 1996
... administration. 4. This study shows that in rats with cirrhosis, pentoxifylline induces a decrease in both portal pressure and plasma tumour necrosis factor-α concentrations. These reductions were not correlated however. 25 3 1996 1 4 1996 © 1996 The Biochemical Society and the Medical Research...
Clin Sci (Lond) (1995) 89 (3): 227-232.
Published: 01 September 1995
...Samuel S. Lee; Jung-Min Pak; Shaun M. Medlicott; Arieh Bomzon 1. There is currently considerable interest in the role of locally produced vasodilators such as nitric oxide and adenosine in the pathogenesis of the peripheral vasodilatation of cirrhosis. However, the signal transduction pathways...
Clin Sci (Lond) (1994) 87 (3): 329-335.
Published: 01 September 1994
...Alastair MacGilchrist; Kathrine J. Craig; Peter C. Hayes; Allan D. Cumming 1. Previous studies have documented activation of protease enzymes, such as the plasma kallikrein-kinin system, in hepatic cirrhosis. Increased plasma kinin generation could contribute to pathological systemic vasodilatation...
Clin Sci (Lond) (1994) 87 (3): 357-362.
Published: 01 September 1994
...M. H. Davies; L. Klovrza; R. H. Waring; E. Elias 1. Fasting levels of plasma cysteine, plasma sulphate and the plasma cysteine/sulphate ratio were measured in patients with primary biliary cirrhosis and compared with those in patients with other liver disease, general intensive therapy unit...
Clin Sci (Lond) (1994) 86 (5): 489-495.
Published: 01 May 1994
...David A. Lomas 1. The Z deficiency variant of α 1 -antitrypsin predisposes the homozygote to early-onset panlobular emphysema and results in the accumulation of antitrypsin within the hepatocyte, which leads to hepatocellular damage and cirrhosis. The mechanism of this accumulation has been shown...
Clin Sci (Lond) (1994) 86 (4): 447-451.
Published: 01 April 1994
... hepatocellular carcinoma or liver cirrhosis caused by chronic viral hepatitis, and correlated with reduced albumin levels in these conditions, indicating that the liver is the site of phosphoinositol-specific phospholipase D synthesis and that phosphoinositol-specific phospholipase D may be used as an additional...
Clin Sci (Lond) (1994) 86 (2): 203-208.
Published: 01 February 1994
...Alison Calver; Adam Harris; J. Douglas Maxwell; Patrick Vallance 1. Nitric oxide (NO) is a potent endogenous vasodilator and plays a role in the control of resting vascular tone. Patients with cirrhosis have a hyperdynamic circulation with reduced blood pressure and decreased peripheral resistance...
Clin Sci (Lond) (1993) 84 (5): 525-529.
Published: 01 May 1993
...David J. Leehey 1. Decreased pressor sensitivity to angiotensin II occurs in cirrhosis, but the mechanism remains unclear. 2. Angiotensin II dose-response studies were performed in conscious, chronically instrumented cirrhotic and control rats, and angiotensin II concentration-response studies were...
Clin Sci (Lond) (1993) 84 (2): 185-192.
Published: 01 February 1993
... viability of the hepatocytes. Cirrhosis was induced by CCl 4 , and Krebs-Ringer bicarbonate buffer solution was used as the perfusate. Portal perfusion pressures were increased incrementally between 25 and 45 cm H 2 O. The viability of the livers was assessed and histological studies were performed under...
Clin Sci (Lond) (1992) 83 (5): 597-605.
Published: 01 November 1992
...Yolanta T. Kruszynska; Janet Munro; Philip D. Home; Neil McIntyre 1. To examine the contributions of hypersecretion and decreased insulin clearance to the hyperinsulinaemia of cirrhosis, insulin secretion was calculated over the day from serum C-peptide concentrations and C-peptide metabolic...
Clin Sci (Lond) (1992) 83 (1): 41-45.
Published: 01 July 1992
...M. Dagenais; G. Pomier-Layrargues; B. Rocheleau; L. Giroux; P.-M. Huet 1. The systemic and splanchnic haemodynamic effects of pentifylline (40 mg/kg body weight intravenously) were assessed in rats with portal hypertension associated either with CCl 4 -induced cirrhosis ( n = 13) or portal vein...
Clin Sci (Lond) (1992) 82 (2): 147-156.
Published: 01 February 1992
... contributory factor to the development of systemic hypotension or the inverted pressor response to a change in posture in cirrhosis. 16 8 1991 18 9 1991 © 1992 The Biochemical Society and the Medical Research Society 1992 cirrhosis noradrenaline orthostatic reflexes vascular...
Clin Sci (Lond) (1991) 81 (2): 177-182.
Published: 01 August 1991
... significantly greater in 35 patients with hepatocellular carcinoma (225 ± 69 nkat/l) than in 35 patients with cirrhosis and 20 normal subjects (134 ± 30 and 93 ± 28 nkat/l, respectively). The overlap between hepatocellular carcinoma and cirrhosis, however, was such as to severely limit any value of the enzyme...
Clin Sci (Lond) (1991) 80 (2): 143-147.
Published: 01 February 1991
... Biochemical Society and the Medical Research Society 1991 angiotensin II cirrhosis glomerular contraction glomeruli receptors renal function Clinical Science (1991) 80,143-147 ',143 Glomerular binding and contractile response to angiotensin I1 in rats with chronic experimental cirrhosis of the...