...Lingling Lu; Weihua Liu; Shumin Li; Mi Bai; Yu Zhou; Zhaohui Jiang; Zhanjun Jia; Songming Huang; Aihua Zhang; Wei Gong Cisplatin-induced nephrotoxicity is the main adverse effect of cisplatin-based chemotherapy and highly limits its clinical use. DMXAA, a flavonoid derivative, is a promising...

...Hao Zhao; Yachun Han; Na Jiang; Chenrui Li; Ming Yang; Ying Xiao; Ling Wei; Xiaofen Xiong; Jinfei Yang; Chengyuan Tang; Li Xiao; Fuyou Liu; Yu Liu; Lin Sun Cisplatin (Cis) can cause chronic kidney disease (CKD) and promote renal fibrosis, but the underlying mechanism is not fully understood...

... is a novel, orally active, small-molecule HIF PHD inhibitor for the treatment of anemia in patients with chronic kidney disease (CKD). The current study aimed to evaluate the effect of FG-4592 (Roxadustat) on cis -diamminedichloroplatinum (cisplatin)-induced kidney injury. In mice, pretreatment with FG-4592...

.... Nonetheless, its specific role in drug-induced nephrotoxicity is poorly understood. Cisplatin (dichlorodiamino platinum) belongs to an inorganic platinum – fundamental chemotherapeutic drug utilized in the therapy of various solid malignant tumors. However, the use of cisplatin is extremely limited by obvious...

...N. I. WEIJL; T. J. ELSENDOORN; R. M. W. MOISON; E. G. W. M. LENTJES; R. BRAND; H. M. BERGER; S. OSANTO Non-protein bound iron (NPBI) is able to catalyse oxidative reactions, causing damage to vital structures. Adverse effects induced by cisplatin seem, in part, to be mediated by free radicals...

...Christopher J. Lote; Ernest S. Harpur; Andrew Thewles; Donna J. Phipps 1. Cisplatin [6 mg/kg body weight, in 0.9% (w/v) NaCl] was injected intraperitoneally as a single dose to two groups of rats (Fischer 344 strain). Two further groups of rats, injected intraperitoneally with an equivalent volume...