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Keywords: clonidine
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Articles
Clin Sci (Lond) (1999) 97 (1): 19–25.
Published: 21 May 1999
...Nuria TEJERA; Gloria BALFAGÓN; Jesús MARÍN; Mercedes FERRER The aim of this study was to determine the possible influence of sex hormones on the contractile responses induced by clonidine, an agonist of α 2 -adrenoceptors, as well as the endothelial modulation of these responses. For this purpose...
Articles
Clin Sci (Lond) (1995) 88 (4): 421–426.
Published: 01 April 1995
... this is due to increased sensitivity at α 1 - or α 2 -adrenergic receptors, we compared vascular responses to the α 1 -adrenergic agonist phenylephrine and the α 2 -adrenergic agonist clonidine. 3. We studied 15 insulin-dependent diabetic patients with microalbuminuria, 15 insulin-dependent diabetic patients...
Articles
Clin Sci (Lond) (1992) 83 (1): 59–64.
Published: 01 July 1992
... before and after administration of clonidine (2 μg/kg body weight intravenously) in 10 patients with multiple-system atrophy, 10 patients with pure autonomic failure and 15 age-matched healthy control subjects. 2. After clonidine, blood pressure fell in patients with multiple-system atrophy and control...
Articles
Clin Sci (Lond) (1985) 68 (1): 35–43.
Published: 01 January 1985
...-enkephalin, arginine vasopressin (AVP) and oxytocin (OXT) in stroke-prone spontaneously hypertensive rats (SHRSP) and in age-matched normotensive Wistar Kyoto (WKY) controls, as well as in SHRSP with normalized blood pressure by chronic treatment with clonidine. Opioid peptide contents were measured in 12...
Articles
Clin Sci (Lond) (1982) 63 (s8): 301s–303s.
Published: 01 October 1982
...V. M. Campes; D. Levitan; M. S. Romoff; Y. Saglikes; I. Sajo; S. G. Massry 1. The effect of clonidine on the relationship between sympathetic nervous system activity and the state of sodium-volume balance was studied in 15 patients with essential hypertension and normal renal function (group 1...
Articles
Clin Sci (Lond) (1982) 63 (s8): 455s–458s.
Published: 01 October 1982
...Bonita Falkner; Gaddo Onesti; Melton B. Affrime; David T. Lowenthal 1. The effects of clonidine and hydrochlorothiazide on the cardiovascular responses to mental stess were compared in 29 adolescents with essential hypertension. 2. Clonidine therapy was associated with lower diastolic pressures...
Articles
Clin Sci (Lond) (1981) 61 (s7): 453s–455s.
Published: 01 December 1981
...M. Andréjak; P. Fievet; R. Makdassi; E. Comoy; J. F. De Fremont; B. Coevoet; A. Fournier 1. In four patients, whose hypertension was not controlled (supine blood pressure > 150–90 mmHg) by addition of 5 mg/day of prazosin to previous treatment (diuretics and β-blockers), clonidine (150–450 μg...
Articles
Clin Sci (Lond) (1981) 61 (3): 273–279.
Published: 01 September 1981
...A. Friggi; H. Bodard 1. The effects of clonidine on the aortic pressure-diameter relationship were studied in anaesthetized rabbits by means of an ultrasonic dimension technique. Midwall aortic stress and aortic elastic modulus were calculated. 2. In spite of a significant decrease in mean aortic...
Articles
Clin Sci (Lond) (1981) 60 (2): 139–143.
Published: 01 February 1981
... the systolic and diastolic increases in pressure. Clonidine reduced the systolic but not the diastolic increase. Oxprenolol alone or in combination with phentolamine or phenyoxybenzamine failed to influence the pressor response. 3. The increase in systemic blood pressure associated with sustained contraction...
Articles
Clin Sci (Lond) (1980) 58 (2): 135–138.
Published: 01 February 1980
...C. Barbieri; C. Ferrari; R. Caldara; G. Curtarelli 1. In an attempt to test the hypothesis of a derangement in central catecholaminergic function in hypertensive patients, the serum growth hormone and prolactin responses to the α-adrenergic agonist clonidine (0·15 mg infused intravenously) and to l...
Articles
Clin Sci (Lond) (1979) 57 (6): 509–514.
Published: 01 December 1979
...T. J. B. Maling; C. T. Dollery; C. A. Hamilton 1. Blood pressure, heart rate, plasma noradrenaline and electroencephalographic variables were measured simultaneously during sleep in five healthy males before and after slow-release clonidine (300 μg orally) or placebo. 2. The blood pressure fall...
Articles
Clin Sci (Lond) (1979) 57 (s5): 425s–428s.
Published: 01 December 1979
...C. J. Mathias; J. L. Reid; L. M. H. Wing; H. L. Frankel; N. J. Christensen 1. The effects of 300 μg of oral clonidine on blood pressure, heart rate, plasma noradrenaline and adrenaline concentrations were studied in seven tetraplegic subjects with physiologically complete cervical spinal cord...
Articles
Clin Sci (Lond) (1979) 57 (s5): 429s–431s.
Published: 01 December 1979
...G. J. Green; H. Wilson; A. M. Breckenridge 1. Clonidine (4 μg/kg) given intracisternally to anaesthetized cats inhibited brain stem-evoked parasympathetic submaxillary or parotid salivation by 62% at 5 Hz and 44% at 15 Hz. 2. The inhibitory action of clonidine on salivation was equally prevented...
Articles
Clin Sci Mol Med (1978) 55 (s4): 259s–261s.
Published: 01 December 1978
...P. A. Van Zwieten; E. Lam; P. B. M. W. M. Timmermans 1. The interaction between prazosin and clonidine was studied in anaesthetized rats, pithed rats and in anaesthetized cats. 2. Prazosin diminished the clonidine-induced hypotensive effect in anaesthetized rats, probably via an antagonism...
Articles
Clin Sci Mol Med (1977) 53 (1): 45–53.
Published: 01 July 1977
...L. M. H. Wing; J. L. Reid; C. A. Hamilton; P. Sever; D. S. Davies; C. T. Dollery 1. A single oral dose of clonidine hydrochloride (300 μg) lowered systolic blood pressure by 20 ± 2 mmHg and diastolic blood pressure by 15 ± 2 mmHg in seven healthy normotensive subjects. 2. Resting supine plasma...
Articles
Clin Sci Mol Med (1976) 51 (s3): 109s–111s.
Published: 01 December 1976
...I. A. Reid; A. Jones 1. Sympathetic reflexes were activated by carotid occlusion in anaesthetized dogs in which changes in renal perfusion pressure were prevented. This produced a prompt and reversible increase in plasma renin activity. 2. Administration of clonidine decreased plasma renin activity...
Articles
Clin Sci Mol Med (1976) 51 (s3): 625s–626s.
Published: 01 December 1976
... significantly. chlorthalidone clonidine low-sodium diet oxprenolol © 1976 The Biochemical Society and the Medical Research Society 1976 Clinical Science and Molecular Medicine (1976) 51, 6259-626s. Comparison of the effects of pharmacological therapy and a low-sodium diet on mild hypertension B. M...
Articles
Clin Sci Mol Med (1976) 51 (s3): 411s–413s.
Published: 01 December 1976
...P. A. Van Zwieten 1. In chloralose-anaesthetized cats the centrally induced hypotensive effect of clonidine, and in some cases α-methyldopa, was diminished by pretreatment with a variety of tricyclic antidepressants and neuroleptic agents. 2. The interaction is assumed to occur at the central α...
Articles
Clin Sci Mol Med (1976) 51 (s3): 423s–426s.
Published: 01 December 1976
...-hypertensive effects of drugs like clonidine, α-methyldopa and β-receptor-blocking agents may be related to their long-term effects on presynaptic adrenoceptors. © 1976 The Biochemical Society and the Medical Research Society 1976 clonidine α-methyldopa phenoxybenzamine presynaptic receptors...
Articles
Clin Sci Mol Med (1976) 51 (s3): 639s–640s.
Published: 01 December 1976
...D. S. Davies; L. M. H. Wing; J. L. Reid; P. Tippett; C. T. Dollery 1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. 2. Plasma half-lives of clonidine ranged from 6·9 to 9·4 h in five normotensive...
Articles
Clin Sci Mol Med (1976) 51 (s3): 641s–643s.
Published: 01 December 1976
...T. L. Kho; G. A. Zaal; A. Wester; P. W. De Leeuw; W. H. Birkenhäger 1. The cardio-renal haemodynamic and endocrine effects of the anti-hypertensive agents 2-(2,6-dichlorophenylamine)-2-imidazoline hydrochloride (clonidine, St 155) and 2-(5-fluor- o -toluidine)-2-imidazoline hydrochloride (St 600...
Articles
Clin Sci Mol Med (1976) 51 (s3): 365s–368s.
Published: 01 December 1976
... reaching plasma concentrations up to 240 (sem 33) ng/ml had no effect on this reflex but reduced mean arterial pressure. However, the response was attenuated by clonidine in a dose-dependent manner. 2. Valsalva manoeuvres were used to elicit graded sympathetically mediated rises in TPR index in twenty-nine...
Articles
Clin Sci Mol Med (1975) 48 (s2): 287s–290s.
Published: 01 January 1975
... and with idiopathic asympatheticotonic hypotension (ASH), and (b) during orthostasis and after administration of frusemide, of the β-blocking agent tenormin, of clonidine and of dihydralazine. 2. In primary hypertension noradrenaline and mean arterial pressure (Pm) showed a close positive correlation. 3. The mean...
Articles
Clin Sci Mol Med (1975) 48 (s2): 273s–276s.
Published: 01 January 1975
...L. Finch 1. Intraventricular clonidine and BAY 1470, administered in small doses to conscious renal hypertensive cats, produced a fall in mean blood pressure lasting for a period of 3 h. This fall in blood pressure was accompanied by a marked bradycardia. 2. Pretreatment with intraventricular...
Articles
Clin Sci Mol Med (1975) 48 (s2): 277s–278s.
Published: 01 January 1975
... region induced a fall in blood pressure and in heart rate related to the administered dose. 3. When injected into the anterior hypothalamus/pre-optic region, clonidine and alpha-methyl-noradrenaline induced a long-lasting decrease in blood pressure and heart rate. © 1975 The Biochemical Society...
Articles
Clin Sci Mol Med (1973) 45 (5): 701–709.
Published: 01 November 1973
... followed by injection of clonidine (1 μg/kg) into the cisterna magna lowered mean arterial pressure (MAP) from 100·5 ± 1·5 mmHg to 45·0 ± 2·5 mmHg. In normal animals treated similarly MAP fell from 79·1 ± 2·3 mmHg to 49·1 ± 3·9 mmHg. 3. In renal hypertensive rabbits with cellophane perinephritis...
Articles
Clin Sci Mol Med (1973) 45 (s1): 199s–203s.
Published: 01 August 1973
...P. Lund-Johansen 1. The effects of hypotensive therapy with three separate diuretics, methyldopa and clonidine were separately assessed. 2. All the treated groups showed a significant drop in blood pressure. 3. Polythiazide and hydrochlorothiazide each produced a significant fall in total...
Articles
Clin Sci Mol Med (1973) 45 (s1): 185s–189s.
Published: 01 August 1973
...A. Salvetti; F. Arzilli; G. C. Zucchelli 1. Clonidine inhibits plasma renin activity (PRA) in hypertensive patients, especially when administered for more than 4 days. 2. This effect is not related to sodium retention, but is probably due to inhibition of the basal sympathetic activity. © 1994...