...Valentina Vaira; Leda Roncoroni; Donatella Barisani; Gabriella Gaudioso; Silvano Bosari; Gaetano Bulfamante; Luisa Doneda; Dario Conte; Carolina Tomba; Maria Teresa Bardella; Stefano Ferrero; Martina Locatelli; Luca Elli CD (coeliac disease) is a frequent autoimmune disorder of the small bowel...

... and the relationship between the distinctive types of mucosal lesions observed in coeliac disease and the number of duodenal CCK cells and their peptide and mRNA content. Duodenal biopsies were obtained in ten controls and nineteen coeliac patients [seven with atrophic mucosa, six with increased numbers...

...Adrian G. CUMMINS; Fiona M. THOMPSON; Ross N. BUTLER; John C. CASSIDY; David GILLIS; Mark LORENZETTI; Emma K. SOUTHCOTT; Peter C. WILSON It is often difficult to assess small bowel recovery in adults with coeliac disease on a gluten-free diet (GFD). This prospective study compares changes...

.... The median 5 h urinary sugar excretion was 0.26% of the ingested raffinose, 0.05% of lactose and 17.5% of l-arabinose. 3. In 143 patients with gastrointestinal disease, excretion of both ingested raffinose and lactose was significantly increased in coeliac disease in relapse or in partial remission...

... permeability in coeliac disease. 2. In patients with clinically proven coeliac disease, 13 out of 14 (93%) had abnormal urinary cellobiose/mannitol ratios, while only five out of 12 (42%) had abnormal urinary recoveries of 51 Cr-EDTA. Thus, the cellobiose/mannitol absorption test is more sensitive...

... with coeliac disease and 11 patients with Crohn's disease. Total mucosal permeation was corrected for surface area measured morphometrically to provide an index of mucosal permeability. 2. In untreated coeliac disease, permeation of mannitol was reduced by 35% ( P = 0.006) and that of raffinose was increased...

... in the pathogenesis of coeliac disease. ClinicalScience( 1987) 12, 593-598 593 Gliadin binding to rat and human enterocytes J. COLYER, P. J. KUMAR, N. M. WALDRON*, M. L. CLARK AND M. J. G. FARTHING Department of Gastroenterology, St Bartholomew s Hospital, and *Department of Chemistty, Queen Mary s College...

... and as such cannot be regarded as true lectins. 4. Mucosal damage in coeliac disease is unlikely therefore to be related to lectin-like activity of gliadin. 31 1 1986 20 2 1986 © 1986 The Biochemical Society and the Medical Research Society 1986 cell agglutination coeliac disease gliadin...

... disease (IBD) and healthy individuals. The coeliac group had significantly higher ( P < 0.05) antibody levels to fraction B than either of the control groups [medians: coeliac disease ( n = 21), 0.247; IBD ( n = 17) 0.019; healthy controls ( n = 13) 0.020]. Five coeliac sera which gave high absorbance...

..., elastin and zein exhibited very low acceptor activities. 3. Increased transglutaminase activity was demonstrated in jejunal biopsies from four patients with untreated coeliac disease compared with 14 control subjects and eight patients with inflammatory bowel disease. Eight patients with coeliac disease...

...P. J. Ciclitira; D. J. Evans; N. L. K. Fagg; E. S. Lennox; R. H. Dowling 1. Since the toxic fraction of cereal flour which damages the small bowel mucosa of patients with coeliac disease has not been fully defined in vivo , we studied the effect of intraduodenal infusions of different doses...

...G. R. Corazza; P. Tabacchi; M. Frisoni; M. Londei; D. Bastia; G. Gasbarrini 1. As a defect of suppressor function has been hypothesized in the pathogenesis of coeliac disease, we measured, by monoclonal antibodies, the inducer/suppressor T-cell ratio in adult coeliac disease. 2. No statistical...

... of assaying for α-gliadin in prepared foods is of special value since α-, β-, γ- and ω-gliadin have been shown to exacerbate coeliac disease. 6 9 1982 10 12 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 coeliac disease gluten free diet and foods...

...G. Kitis; M. L. Lucas; H. Bishop; A. Sargent; R. E. Schneider; J. A. Blair; R. N. Allan 1. Propranolol and folic acid absorption were studied separately in healthy subjects, non-coeliac patients and patients with treated and untreated coeliac disease. 2. The surface pH of jejunal biopsy samples...

... is decreased in the proximal jejunum in untreated coeliac disease but overall absorption in the small bowel is not impaired. 21 10 1981 29 1 1982 © 1982 The Biochemical Society and the Medical Research Society 1982 absorption coeliac disease jejunum propranolol Clinical Science...

...G. R. Corazza; A. W. Bullen; R. Hall; P. J. Robinson; M. S. Losowsky 1. Erythrocytes with membrane abnormalities seen on interference contrast microscopy (‘pitted erythrocytes’) were counted in venous blood samples from patients with treated coeliac disease and dermatitis herpetiformis, and from...

...T. J. Peters; P. E. Jones; G. Wells 1. Portions of jejunal biopsy specimens from patients with coeliac disease were homogenized in isotonic sucrose solution and subjected to analytical subcellular fractionation by sucrose-density-gradient centrifugation. 2. The activities and distribution of marker...

... with coeliac disease. 5. The possible location of such pores in the gastrointestinal mucosa is discussed in relation to the cell membrane, the intercellular junction, and the sites of cell exfoliation. 28 6 1977 8 11 1977 © 1978 The Biochemical Society and the Medical Research Society 1978...

...T. J. Peters © 1977 The Biochemical Society and the Medical Research Society 1977 coeliac disease congestive cardiomyopathy enzyme analysis granulomatous Clinical Science and Molecular Medicine (1977) 53, 505-51 1. EDITORIAL REVIEW Application of analytical subcellular fractionation...

... The Biochemical Society and the Medical Research Society 1977 brush-border enzymes coeliac disease gliadin intestine mucosa xylose Clinical Science and Molecular Medicine (1977) 53,3543. Coeliac disease: the abolition of gliadin toxicity by enzymes from Aspergillus niger J. J. PHELAN, FIONA M...

...J. F. MacKenzie; R. I. Russell 1. Pteroylmonoglutamic acid (PteGlu) absorption has been measured by using the technique of small-intestinal perfusion with tritiated PteGlu in normal subjects and in patients with coeliac disease. 2. At similar intrajejunal pH, patients with untreated coeliac disease...

...T. J. Peters; J. R. Heath; M. H. Wansbrough-Jones; W. F. Doe 1. Reduced activities of four enzymes from brush borders were found in intestinal biopsies from patients with untreated coeliac disease. The activities returned towards control values after treatment by gluten withdrawal. Parallel changes...