... simultaneously treated with C21 (1 mg/kg/day, in the drinking water), generating four groups: Chow C, Chow C21, HF C, and HF C21. Vascular function and mechanical properties were determined in the abdominal aorta. To evaluate ECM remodeling, collagen deposition and TGF-β 1 concentrations were determined...

... in the fibrogenic process, as well as molecules that stimulate such cells to produce elevated amounts of collagen and other ECM-related proteins. In the present review, we assess the current knowledge about cellular and molecular mediators of intestinal fibrosis and describe results of recent studies aimed...

...-treated wounds, the pattern of neutrophil inflammatory response suggests faster clearing of the burned dead tissue. We also observe faster resolution of the pro-inflammatory macrophages. We also found that insulin stimulates collagen deposition and maturation with the fibres organized more like a basket...

...). However, it is not known whether Ac-SDKP decreases collagen cross-linking and lymphocyte infiltration; lymphocytes modulate both collagen cross-linking and ECM (extracellular matrix) formation in hypertension. Thus we hypothesized that (i) in AngII (angiotensin II)-induced hypertension, Ac-SDKP prevents...

... of AMPK activity by AICAR inhibited HSC proliferation, as expected, as well as collagen α1(I) expression. Importantly, AMPKα1 deletion inhibited proliferation of HSCs, but not fibrogenesis, in vivo . Moreover, AMPKα1 deletion was not associated with enhanced CCl 4 -induced fibrosis in vivo . In conclusion...

... strains is due to the difference in collagen content following MI. In the present study, we compared the difference in matrix remodelling post-MI between β 2 -TG and NTG mice and between mice and rats. MI was induced by ligation of the left main coronary artery. Following MI, tensile strength, insoluble...

.... This was associated with a significant attenuation of both basal and hypoxia/re-oxygenation-induced collagen production by the fibroblasts. Cytokine production, specifically TGFβ (transforming growth factor β), by these cells was also significantly attenuated by ACE2 expression. Collectively, these results indicate...

... cell, significant contributions may occur from other cell lineages, including those from distant sites such as bone marrow stem cells. cirrhosis collagen fibrosis hepatic stellate cell inflammation liver myofibroblast Fibrosis of the liver and its end stage, cirrhosis, represents...

... by repressing the AP-1 signalling pathway in vascular endothelial cells. We investigated effects of the PPARα activator fenofibrate (80mg/kg per day, per os ) on mRNA levels of ET-1, collagen type I and type III and histological features of myocardial fibrosis in hypertrophied rat hearts due to pressure...

... in a double-blind randomized controlled trial, and who received either oral continuous combined HRT (Kliogest ® ; 2 mg of oestradiol+1 mg of norethisterone) or placebo for a minimum of 6 months. Platelet aggregation was measured by whole-blood impedance aggregometry in response to the agonists collagen...

...Jeffrey D. BRADY; Julia JU; Simon P. ROBINS An ELISA was developed for the measurement of N-telopeptides of the α2(I) collagen chain containing an isomerized Asp-Gly bond (β-peptide) using polyclonal antibodies raised against the synthetic peptide. The presence of this isomerized form in bone...

... collagen, synthesized by fibroblasts, was increased in two of the patients with osteogenesis imperfecta type I and in the daughter with osteogenesis imperfecta type III, but was normal in all the other patients with idiopathic juvenile osteoporosis and the other relatives. 3. Radiolabelled collagen...

...Tsukasa Nakamura; Isao Ebihara; Yasuhiko Tomino; Hikaru Koide 1. We examined the effects of methylprednisolone on the levels of messenger RNA encoding for extracellular matrix components, including α1(IV) collagen chain, laminin B1 and B2 chains, heparan sulphate proteoglycan and α1(I) and α1(III...

... induced by PAF and collagen. 2. Collagen and PAF induced aggregation and secretion in human platelets in a dose-related manner. 3. Aspirin inhibited the magnitude of both platelet aggregation and secretion induced by PAF and collagen, but the degree of inhibition was much greater for collagen. 4. Aspirin...

... aggregation in response to adenosine 5′-pyrophosphate, thrombin, adrenaline and collagen. Platelet sensitivity to prostacyclin was also examined. 3. Platelet noradrenaline showed a positive correlation with extent of aggregation induced by ‘low-dose’ collagen (1 μg/ml). No correlation was seen at the higher...

...John P. Gage; Martin J. O. Francis; Gill E. Whitaker; Roger Smith 1. In osteogenesis imperfecta the bones are brittle but the teeth, whose dentine contains the same genetic collagen as bone (type I), may be clinically normal. 2. To investigate this paradox we have measured the amino acid...

...Jacqueline M. E. Kirk; P. E. Da Costa; Margaret Turner-Warwick; R. J. Littleton; G. J. Laurent 1. To assess the role of changes in lung collagen in pulmonary fibrosis, the content of this protein was measured in biopsy and autopsy lung from patients with cryptogenic fibrosing alveolitis (CFA...

...H. M. James; J. T. Dabek; D. R. Chettle; P. W. Dykes; J. H. Fremlin; J. Hardwicke; B. J. Thomas; D. Vartsky 1. The classical literature shows that wasting of body protein takes place mainly from the cellular compartment leaving high proportions of extracellular collagen. Whole body nitrogen (WBN...

... the renal arteries. 2. A twofold increase in the cyclic AMP level of the thoracic aorta was observed in 9-day hypertensive rats when compared with sham-operated controls. At this time the total amounts of DNA and collagen were unchanged, although a marked increase in arterial fibrous protein was already...

... The Biochemical Society and the Medical Research Society 1981 cholesterol collagen fibrogenesis steatosis Clinical Science (1981) 61,253-256 253 SHORT COMMUNICATION Increased hepatic fibrogenesis in the cholesterol-fed mouse S . P . LEE Gastroenterology Section, Department ofhledicine, University...

...G. L. Rorive; P. J. Carlier; J. M. Foidart 1. Renal hypertension produces a marked and rapidly detectable hypertrophy of the rat aorta, due to smooth muscle cell hyperplasia and connective tissue deposition. 2. As we described previously for collagen synthesis, cell hyperplasia is a very early...

... to hydroxylysine plus lysine in the vascular collagen was increased in 6-month-old SP—SH rats and SR—SH rats as compared with WK rats. 3. An age-related increase in uronic acid and hexose content of the aorta was noted in SP—SH, SR—SH and WK rats. However, the increase was more prominent in SH rats, especially SP...

...J. M. Foidart; G. L. Rorive; B. V. Nusgens; C. M. Lapiere 1. Biosynthesis and deposition of collagen, as well as DNA and total proteins, are increased in aortae of rats after 1, 3 and 6 weeks of hypertension. 2. The maximal increase in the rate of synthesis of collagen is observed within one week...

...C. R. Lovell; A. C. Nicholls; M. I. V. Jayson; A. J. Bailey 1. Normal synovial membrane contains approximately equal proportions of two genetically distinct forms of collagen, types I and III. The proportion of these two collagens is unchanged in rheumatoid synovium but in addition a small amount...

...A. J. Bailey; T. J. Sims; G. Gabbiani; S. Bazin; M. Lelous 1. In contrast to collagen from the aponeurosis of normal adult subjects, the nodules, contractures and apparently unaffected aponeurosis from patients with Dupuytren's disease contained substantial amounts of type III collagen. 2...

...M. J. O. Francis; M. C. Sanderson; R. Smith 1. Skin collagen from fifteen patients with idiopathic adolescent scoliosis, three with congenital scoliosis, and fourteen patients with various degrees of Marfan's syndrome has been examined. 2. The stability of a polymeric collagen fraction, extracted...