...Kai Jiang; Haiyan Chen; Kefeng Ding In the present commentary, we discuss new observations stating that angiopoietin-like protein 1 (ANGPTL1) attenuates cancer metastasis and stemness through Forkhead box O-3a (Foxo3a)–SRY-related HMG-box-2 (Sox2) axis in colorectal cancer ( Clin. Sci . (2022) 136...

... that the molecular mechanisms of ANGPTL1 in colorectal cancer stem cell progression may provide a novel therapeutic strategy for CRC. ANGPTL1 cancer stem cell colorectal cancer FOXO3a liver metastasis SOX2 Cells were lysed in RIPA lysis buffer supplemented with protease inhibitor cocktail (cat...

...Phimmada Hatthakarnkul; Jean A. Quinn; Aula Ammar; Gerard Lynch; Hester Van Wyk; Donald C. McMillan; Chanitra Thuwajit; Joanne Edwards Colorectal cancer (CRC) is the third most common cancer worldwide. Poor survival of CRC associated with the development of tumour metastasis led...

...Huaiming Wang; Rongkang Huang; Wentai Guo; Xiusen Qin; Zifeng Yang; Zixu Yuan; Yingqi Wei; Chunlin Mo; Zhantao Zeng; Jian Luo; Jian Cai; Hui Wang Colorectal cancer (CRC) is often diagnosed at later stages after it has metastasized to other organs. The development of chemoresistance also contributes...

...Francesco Mannavola; Gaetano Pezzicoli; Marco Tucci Exosomes (Exo) have emerged as potent amplifiers of pro-tumorigenic signals to distant cells. The knowledge of their role in colorectal cancer (CRC) is continuously up-growing, although their contribution to metastasis remains largely unclear. Liu...

..., we investigated the miRNA expression profiles of 5 paired serum exosomal samples from metastatic colorectal cancer (mCRC) and non-mCRC patients via RNA sequencing. After we evaluated the differentially expressed miRNAs in 80 CRC patients, miR-106b-3p was selected as a metastasis-associated miRNA...

...Xiao-Yu Liu; Chang-Bo Zheng; Teng Wang; Jian Xu; Meng Zhang; Ling-Shan Gou; Linfang Jin; Xiaowei Qi; Xianhai Zeng; Hongwen Li; Shuqi Qiu; Peng Zhang Colorectal cancer (CRC) is the third most common malignancies in adults. Similar to other solid tumors, CRC cells show increased proliferation...

... ( NR4A1 ) acts as an oncogene, and is involved in colorectal cancer (CRC) development. However, the mechanism through which lncRNA regulates NR4A1 expression remains unknown. We aimed to identify lncRNAs that regulate NR4A1 and assess their underlying mechanisms in CRC. We first identified an antisense...

... in various tumors. However, the expression pattern and biological function of circRNAs in colorectal cancer (CRC) still remain largely unexplored. In the present study, hsa_circ_0009361 was significantly down-regulated in CRC tissues and cells. Low expression level of hsa_circ_0009361 promoted...

... be involved in the development of colorectal cancer (CRC), especially through the production of genotoxins such as colibactin and/or by interfering with the DNA mismatch repair (MMR) pathway that leads to microsatellite instability (MSI). The present study, performed on 88 CRC patients, revealed a significant...

...-selective Ca 2+ channel. The architecture of the TrpC5 channel is poorly understood. In the present study, we report that TrpC5 is a key factor in regulating differentiation in colorectal cancer (CRC). Through a study of specimens from a large cohort of patients with CRC, we found that TrpC5 was highly...

... this hypothesis for colorectal cancer (CRC). ApoE genotype was determined in 206 patients with CRC and 353 healthy controls from the East Anglia region of the U.K. Compared with individuals possessing the most common ɛ3/ɛ3 genotype, those with the ɛ2/ɛ3 genotype had an increased risk of colon cancer [odds ratio...

.... Correspondence: Professor G. J. Maddern (e-mail [email protected] ). 13 7 2001 6 11 2001 8 12 2001 The Biochemical Society and the Medical Research Society © 2002 2002 ablation colorectal cancer electrolysis liver pigs. 389Clinical Science (2002) 102, 389 395...

... in patients with colorectal cancer. 2. Total serum cytokines - interleukin (interleukin-1β, 2, 4 and 6), tumour necrosis factor-α and interferon-γ - were analysed using the enzyme-linked immunosorbent assay technique at different time intervals during the course of essential fatty acid supplementation. 3...