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Keywords: compound 21
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Articles

AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet

Raquel González-Blázquez, Martín Alcalá, José Miguel Cárdenas-Rebollo, Marta Viana, Ulrike Muscha Steckelings, William A. Boisvert, Thomas Unger, María S. Fernández-Alfonso, Beatriz Somoza, Marta Gil-Ortega
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2763–2780.
https://doi.org/10.1042/CS20210971
Published: 17 December 2021
...Raquel González-Blázquez; Martín Alcalá; José Miguel Cárdenas-Rebollo; Marta Viana; Ulrike Muscha Steckelings; William A. Boisvert; Thomas Unger; María S. Fernández-Alfonso; Beatriz Somoza; Marta Gil-Ortega The aim of the present study was to evaluate the effect of Compound 21 (C21), a selective...
View article titled, AT 2 R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet
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Includes: Supplementary data
Articles

C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors

Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
https://doi.org/10.1042/CS20210049
Published: 11 May 2021
...Raquel González-Blázquez; Martín Alcalá; María S. Fernández-Alfonso; Ulrike Muscha Steckelings; M. Paz Lorenzo; Marta Viana; William A. Boisvert; Thomas Unger; Marta Gil-Ortega; Beatriz Somoza Compound 21 (C21), a selective agonist of angiotensin II type 2 receptor (AT 2 R), induces vasodilation...
View article titled, C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors
Open the PDF for C21 preserves endothelial function in the thoracic aorta from DIO mice: role for AT 2 , Mas and B 2 receptors in another window
Includes: Supplementary data
Articles

The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role

Paul-Emmanuel Vanderriele, Brasilina Caroccia, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Francesca Torresan, Maurizio Iacobone, Thomas Unger, Gian Paolo Rossi
Journal: Clinical Science
Clin Sci (Lond) (2018) 132 (6): 627–640.
https://doi.org/10.1042/CS20171593
Published: 20 March 2018
..., and in APA-adjacent tissue. The effect of Compound 21 (C21), an AT2R agonist, on CYP11B1 (cortisol synthase) and CYP11B2 (aldosterone synthase) gene expression in NCI-H295R and HAC15 cell lines, and in APA and APA-adjacent tissue, was also assessed using the AT1R antagonist irbesartan to ascertain...
View article titled, The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role
Open the PDF for The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role in another window
Includes: Supplementary data
Articles

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

Bryna S.M. Chow, Terri J. Allen
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (15): 1307–1326.
https://doi.org/10.1042/CS20160243
Published: 29 June 2016
... 6 5 2016 AT2 receptor AT2R agonism cardiovascular compound 21 kidney The biological actions of the renin–angiotensin system (RAS) are regarded to be primarily mediated by the octapeptide, angiotensin II (Ang II). Originally thought to be a circulating endocrine hormone that acts...
View article titled, Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease
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Articles

Hypotensive and sympathoinhibitory responses to selective central AT 2 receptor stimulation in spontaneously hypertensive rats

Sofie Brouwers, Ilse Smolders, Richard D. Wainford, Alain G. Dupont
Journal: Clinical Science
Clin Sci (Lond) (2015) 129 (1): 81–92.
https://doi.org/10.1042/CS20140776
Published: 15 April 2015
... pressure responses to stimulation of central AT 2 Rs by the selective agonist Compound 21 in conscious spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY rats). We also assessed the impact on noradrenaline [norepinephrine (NE)] plasma levels, autonomic function, spontaneous...
View article titled, Hypotensive and sympathoinhibitory responses to selective central AT 2 receptor stimulation in spontaneously hypertensive rats
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Includes: Supplementary data
Articles

Activation of intracellular angiotensin AT 2 receptors induces rapid cell death in human uterine leiomyosarcoma cells

Yi Zhao, Ulf Lützen, Jürgen Fritsch, Maaz Zuhayra, Stefan Schütze, Ulrike M. Steckelings, Chiara Recanti, Pawel Namsoleck, Thomas Unger, Juraj Culman
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (9): 567–578.
https://doi.org/10.1042/CS20140627
Published: 11 February 2015
... II and the AT 1 receptor antagonist, losartan, induces apoptosis but does not affect the rate of cell death. We demonstrate for the first time that the high-affinity, non-peptide AT 2 receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular...
View article titled, Activation of intracellular angiotensin AT 2 receptors induces rapid cell death in human uterine leiomyosarcoma cells
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Articles

Relative affinity of angiotensin peptides and novel ligands at AT 1 and AT 2 receptors

Sanja Bosnyak, Emma S. Jones, Arthur Christopoulos, Marie-Isabel Aguilar, Walter G. Thomas, Robert E. Widdop
Journal: Clinical Science
Clin Sci (Lond) (2011) 121 (7): 297–303.
https://doi.org/10.1042/CS20110036
Published: 07 June 2011
... of binding affinities of all the major angiotensin peptides. Additionally, we tested the novel AT 2 R agonist Compound 21, as well as the Mas R ( Mas receptor) agonist and antagonist AVE0991 and A-779 respectively, for their ability to bind to AT 1 R or AT 2 R. Candesartan, CGP42214 and PD123319 were used...
View article titled, Relative affinity of angiotensin peptides and novel ligands at AT 1 and AT 2 receptors
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