... response to varying sodium intake is suggested both by regression analysis and by the effect of 5 day's treatment with a converting enzyme inhibitor (enalapril) in six other uraemic patients on a normal (100 mmol/day) sodium intake. Such treatment, although resulting in a significant increase in plasma...

...C. Barres; C. Cerutti; C. Z. Paultre; J. Sassard 1. The acute and chronic cardiovascular effects of S9490-3, a new converting enzyme inhibitor, were studied by means of a computerized analysis of the intra-aortic blood pressure recorded for 48 consecutive hours, in the conscious, unrestrained adult...

...M. G. Collis; J. R. Keddie 1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat mesenteric arteries...

... captopril converting enzyme inhibitor hypertension saralasin sodium Clinical Science (1980) 59,75~-78s 75 s Angiotensin I1 and not sodium status is the major determinant of the agonistic/antagonistic balance of saralasin s actions R. F A G A R D , A. A M E R Y A N D P . L I J N E N Hypertension...

...D. P. Clough; R. Hatton; J. Conway; S. A. Adigun 1. Lower-body subatmospheric pressure has been used to stimulate sympathetic reflexes in anaesthetized cats and the effects of an angiotensin converting enzyme inhibitor and [Sar 1 , Ala 8 ]angiotensin II have been investigated on this reflex. 2...

... used to investigate the role angiotensin plays in blood pressure control. 2. The initial plasma renin activity (2.9 ng of angiotensin I h −1 ml −1 ) did not change during the brief lowering of pressure. Before pressure was lowered neither the angiotensin-converting enzyme inhibitor nor a competitive...

...E. S. Marks; R. F. Bing; H. Thurston; J. D. Swales 1. The peptide converting enzyme inhibitor captopril was given (1·25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent...

... response, both surgical procedures lowered plasma renin concentration to normal or below normal values. 3. Administration of the oral converting enzyme inhibitor SQ 14 225 produced a marked fall in blood pressure in Goldblatt kidney rats with chronic hypertension. However, a prolonged infusion...

... renovascular or DOCA hypertension. © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin II converting enzyme inhibitor DOCA hypertension Goldblatt two-kidney one-clip hypertension noradrenaline pressor response Clinical Science (1979) 57,47tSOs Pressor...

...D. B. Case; S. A. Atlas; J. H. Laragh 1. Saralasin and converting enzyme inhibitors SQ 20881 and captopril induced increases in plasma renin activity to greater than 14 ng h −1 ml −1 in 43 out of 44 patients with untreated renovascular hypertension when studied in the seated position and on normal...

... 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 angiotensin II converting enzyme inhibitor renal haemodynamics sodium excretion Clinical Science (1979), 56,365-371 Action of angiotensin I converting enzyme inhibitor on the control of renal function in the cat...

...R. J. Cody, Jr; R. C. Tarazi; E. L. Bravo; F. M. Fouad 1. The haemodynamic effects of oral converting enzyme inhibitor (SQ 14225) were assessed in eight patients with severe essential or renovascular hypertension. 2. Mean arterial pressure fell (149 ± 5 to 127 ± 8 mmHg, P < 0.02), because...

... ‘natural’ substrate and is subsequently converted into angiotensin II. © 1975 The Biochemical Society and the Medical Research Society 1975 angiotensin II antagonist converting enzyme inhibitor isolated rat kidney plasma renin substrate renal haemodynamics tetradecapeptide renin substrate...

... renin substrate converting enzyme inhibitor renal haemodynamics Clinical Science (1973) 44, 447.456. CONVERSION O F ANGIOTENSIN I INTO ANGIOTENSIN I1 I N THE ISOLATED PERFUSED RAT KIDNEY K. G. HOFBAUER, H. ZSCHIEDRICH, W. R A U H AND F. GROSS Department of Pharmacology, University of Heidelberg...