...Katherine M. Davies; Julian F.B. Mercer; Nicholas Chen; Kay L. Double Copper is a biometal essential for normal brain development and function, thus copper deficiency or excess results in central nervous system disease. Well-characterized disorders of disrupted copper homoeostasis with neuronal...

... hepatic copper there was a small decrease, but urinary copper excretion was unaltered. Hepatic organelle pathology was significantly improved. 3. No serious side-effects were noted and it is suggested that a controlled trial of low-dose D-penicillamine therapy is indicated in patients with primary biliary...

...Kathleen Gibbs; J. M. Walshe 1. A screening procedure is described to assess rapidly the clinical potential of chelating agents for the treatment of Wilson's disease. 2. Rats were used as the test animal; they were kept in metabolic cages and the urine was collected in copper-free containers...

... and peptide-bound amino acid output in cases of Wilson's disease and in control subjects was mainly quantitative; the pattern of amino acid excretion was qualitatively similar in both groups. 4. Evidence is presented that the increased copper output in the urine in the disease is not secondary to peptiduria...

... weight exceeding 50 000. The remaining biliary 64 Cu was in a low-molecular-weight component. 3. Above pH 4, 64 Cu could not readily be removed from the macromolecular complex either by excess carrier copper ions, by d-penicillamine or by EDTA. 4. Absorption of 64 Cu from 64 Cu-labelled bile injected...