...; atrial, ventricular and lung weights were increased. Coronary artery adventitial and medial thickness were increased, but mesenteric arterial wall morphology was unaffected. Coronary artery relaxation to ACH, ISO, FSK and SNP were reduced in banded animals. In contrast, relaxation of mesenteric arteries...

... in the literature. We also examined the expression of 5-HT 1B receptors in atherosclerotic and normal coronary arteries. The vasocontractile responses to sumatriptan, rizatriptan or eletriptan were characterized by in vitro pharmacology. The ratio of C max /EC 50 was calculated. 5-HT 1B and 5-HT 1D receptors were...

... whether insulin (1.4×10 −7 M) and the β-adrenoceptor antagonist, propranolol (10 −5 M), increase hypoxic vasodilation in correspondence with changes in glycolysis. Porcine coronary arteries, precontracted with 10 −5 M prostaglandin F 2α , were mounted in a pressure myograph and a microdialysis catheter...

... differ from a lipid mediator (TxA 2 ), with a short physiological half life, in human coronary artery disease (CAD). Secondly, to determine if receptor protein is present in human coronary artery vascular smooth muscle for the recently adopted peptide orphan receptors for urotensin-II, apelin and ghrelin...

...Stuart J. Bund 1. Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (∼200 μm internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) controls were compared under pressurized no-flow conditions after...

...Susana R. Garcia; Stuart J. Bund 1. The endothelium contributes substantially to the modulation of myogenic tone in coronary arteries from spontaneously hypertensive rats (SHR) and Wistar—Kyoto rats (WKY). This study has addressed the contributions of endothelium-derived nitric oxide and cyclo...

.... Insight into the relation between age, the atherosclerotic process and vessel wall elasticity may contribute to the prevention of secondary vascular wall damage. 2. To evaluate the determinants of coronary artery wall elasticity, we studied a group of 34 patients, aged 54.6 ± 10.1 years, who underwent...

...Bing Sun; Anthony P. Davenport; Morris J. Brown 1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial...