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Keywords: coronavirus
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Articles

Host cell glutamine metabolism as a potential antiviral target

Sandro Massao Hirabara, Renata Gorjao, Adriana Cristina Levada-Pires, Laureane Nunes Masi, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Eliane Borges da Silva, Laiane Cristina dos Santos-Oliveira, Vinicius Leonardo Sousa Diniz, Tamires Afonso Duarte Serdan, Vivian Araujo Barbosa de Oliveira, Diego Ribeiro de Souza, Raquel Bragante Gritte, Talita Souza-Siqueira, Raquel Freitas Zambonatto, Tania Cristina Pithon-Curi, Roberto Barbosa Bazotte, Philip Newsholme, Rui Curi
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (2): 305–325.
https://doi.org/10.1042/CS20201042
Published: 22 January 2021
...: Sandro Massao Hirabara ( [email protected] ) * These authors contributed equally to this work. 07 08 2020 08 12 2020 04 01 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Coronavirus glutamate...
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Articles

Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Carlos M. Ferrario, Sarfaraz Ahmad, Leanne Groban
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (19): 2645–2664.
https://doi.org/10.1042/CS20200901
Published: 16 October 2020
...Carlos M. Ferrario; Sarfaraz Ahmad; Leanne Groban The virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the aggressive nature of the disease has transformed the universal pace of research in the desperate attempt to seek effective therapies to halt...
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Articles

Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19

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ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
Nigel M. Hooper, Daniel W. Lambert, Anthony J. Turner
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2489–2501.
https://doi.org/10.1042/CS20200476
Published: 29 September 2020
... [ 88 ] and two porcine coronaviruses: pEDV, pTGEV; and dipeptidyl peptidase-4 (DPP4; CD26) is the entry point for hCoV-EMC/2012 causing Middle East Respiratory Syndrome (MERS) [ 89 ]. In late 2019, another zoonotic coronavirus causing severe respiratory (and systemic) symptoms emerged in China...
View articletitled, Discovery and characterization of ACE2 – a 20-year journey of surprises from vasopeptidase to COVID-19
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Articles

Correction: Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
https://doi.org/10.1042/CS-20200904_COR
Published: 09 September 2020
.... , Xiong Y. , Liu H. , Niu L. , Guo J. , Liao M. et al . ( 2020 ) Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies . Mod. Pathol. 10 – 12 5. Sabroe I. , Parker L.C. , Dower S.K. and Whyte M.K.B...
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Articles

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

In Collection
Coronavirus
Daniella S. Battagello, Guilherme Dragunas, Marianne O. Klein, Ana L.P. Ayub, Fernando J. Velloso, Ricardo G. Correa
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2137–2160.
https://doi.org/10.1042/CS20200904
Published: 21 August 2020
...Daniella S. Battagello; Guilherme Dragunas; Marianne O. Klein; Ana L.P. Ayub; Fernando J. Velloso; Ricardo G. Correa The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – discovered...
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Articles

ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

In Collection
Coronavirus
Rhian M. Touyz, Hongliang Li, Christian Delles
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 747–750.
https://doi.org/10.1042/CS20200363
Published: 07 April 2020
... , 270 – 273 10.1038/s41586-020-2012-7 32015507 22. WHO . https://www.who.int/emergencies/diseases/novel-coronavirus-2019 23. Li B. , Si H.R. , Zhu Y. , Yang X.L. , Anderson D.E. , Shi Z.L. et al . ( 2020 ) Discovery of bat coronaviruses through...
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Articles

Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?

In Collection
Coronavirus
Daniel Batlle, Jan Wysocki, Karla Satchell
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (5): 543–545.
https://doi.org/10.1042/CS20200163
Published: 13 March 2020
... to combat or limit infection progression caused by coronaviruses that utilize ACE2 as a receptor ( Figure 1 ). Figure 1 Schematic of coronavirus (CoV) spike protein (S) binding to the surface receptor which is the full-length ACE2 Soluble ACE2 administration may intercept the coronavirus. (Drawn...
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Articles

SARS: clinical presentation, transmission, pathogenesis and treatment options

In Collection
Coronavirus
Paul K. S. Chan, Julian W. Tang, David S. C. Hui
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (2): 193–204.
https://doi.org/10.1042/CS20050188
Published: 17 January 2006
... (transmissible gastroenteritis virus) and PDEV, (porcine diarrhoea epidemic virus)], feline [FIPV (feline infectious peritonitis virus)] and canine coronaviruses; Group 2 contains HuCoV-OC43 along with MHV (mouse hepatitis virus), bovine coronavirus and haemagglutinating encephalomyelitis virus; and Group 3...
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