...William J. Anderson; Philip M. Short; Peter A. Williamson; Arvind Manoharan; Brian J. Lipworth The murine asthma model shows that switching off airway β 2 receptors with an inverse agonist may confer anti-inflammatory effects as well as corticosteroid-sparing activity. We have assessed for any...

...Simon G. Royce; Amelia Sedjahtera; Chrishan S. Samuel; Mimi L. K. Tang Although CSs (corticosteroids) demonstrate potent effects in the control of airway inflammation in asthma, many patients continue to experience symptoms and AHR (airway hyper-responsiveness) despite optimal treatment...

... corticosteroid fibrosis lung function matrix remodelling Airway remodelling is a term that indicates changes in the composition, quantity and organization of the cellular and molecular components of the airway wall, alterations considered secondary to chronic injury and repair of the airway...

...B. Danneskiold-Samsøe; G. Grimby 1. Thirty-five female patients, mean age 63 years, suffering from rheumatoid arthritis participated the study. Twenty patients had been on long-term low-dose corticosteroid treatment. Fifteen patients had never received corticosteroids. A control group of 15 age...

...B. Danneskiold-Samsøe; G. Grimby 1. Abnormal morphological and enzymatic patterns in the lateral vastus muscle have been found in women with corticosteroid treated rheumatoid arthritis. By means of biopsies from the lateral heads of right gastrocnemius muscles, the histology and enzyme activities...

... in both mean systolic and mean diastolic blood pressure was paralleled by an increase in the prevalence of arbitrarily defined hypertension. 3. There was no relationship between change of blood pressure and either dose of corticosteroid or duration of therapy. Blood pressure before therapy was the main...