... for this article was enabled by the participation of Karolinska Institutet, in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. airway hyperresponsiveness asthma cough guinea pig model organisms remodelling Respiratory diseases have a complex...

...Joan Antoni Fernández-Blanco; Mònica Aguilera; Anna Domènech; Gema Tarrasón; Neus Prats; Montse Miralpeix; Jorge De Alba Fibrotic lung diseases, such as idiopathic pulmonary fibrosis, are associated with spontaneous dry cough and hypersensitivity to tussive agents. Understanding the pathophysiology...

...P.W. Barry; N.P. Mason; M. Riordan; C. O'Callaghan 1. Travellers to high altitude often complain of paroxysmal cough, which has not been previously investigated. We recorded overnight cough frequency and cough-receptor sensitivity to inhaled citric acid in a group of climbers travelling to 5300 m...

...Wayne Sunman; Peter S. Sever © 1993 The Biochemical Society and the Medical Research Society 1993 angto-oedema angiotensin II angiotensin-converting enzyme inhibitors bradykinin cough endothelium-derived relaxing factor eicosanoids enkephalin renin-angiotensin system Clinical...

... in random order. 2. The mean number of coughs per challenge decreased with increasing inspiratory flow rate. The difference in cough numbers were significant: 7.7 (95% confidence interval 2.5–12.8) for 50 versus 100 litres/min and 10.9 (95% confidence interval 5.0–16.9) for 100 versus 150 litres/min. 3...

...Manuel J. Barros; Stefano J. Zammattio; P. John Rees 1. The cough response to inhalation of citric acid is produced mainly by irritation of the larynx and trachea. Variations in the inspiratory flow rate might lead to changes in deposition of the drug, and consequently in the cough threshold. 2. We...

...R. H. Lowry; A. M. Wood; T. W. Higenbottam 1. The chemosensitivity of cough receptors stimulated by inhalation of aqueous aerosols was evaluated in 21 normal volunteers in three experiments. 2. The pH of isotonic saline was altered using small amounts of phosphate or glycine buffers to produce...

...Claudio CaRdone; Federico Bellavere; Marcello Ferri; Domenico Fedele 1. To differentiate between the possible reflex and mechanical components in the heart rate response to cough, eight healthy subjects performed a standardized cough test before and after pharmacological autonomic blockade; to test...

...D. J. Godden; C. Borland; R. Lowry; T. W. Higenbottam 1. The purpose of this study was to test whether cough response to inhaled ultrasonically nebulized fluid is dependent on the ionic content of the fluid. 2. Coughing was recorded in human volunteers during inhalation of aqueous solutions...