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Keywords: cyclosporin A
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Clin Sci (Lond) (2017) 131 (13): 1429–1436.
Published: 23 June 2017
...Sandra Bodeau; Chloé Sauzay; Olivier Pluquet; Gabriel Choukroun; Antoine Galmiche Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically...
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Articles
Clin Sci (Lond) (1999) 97 (3): 283–290.
Published: 15 July 1999
...Andreu FERRER-MARTÍNEZ; Antonio FELIPE; Pedro BARCELÓ; Francisco J. CASADO; José BALLARÍN; Marçal PASTOR-ANGLADA Cyclosporin A (CsA) may exert its cytotoxic effects by altering the activity of different plasma membrane transport systems. Although CsA may act at the gene level, it has been also...
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Articles
Clin Sci (Lond) (1994) 86 (5): 627–632.
Published: 01 May 1994
...A. J. Shaw; M. E. Hayes; M. Davies; B. D. Edwards; F. W. Ballardie; R. J. G. Chalmers; E. B. Mawer 1. Cyclosporin A, an immunosuppressive drug used to treat psoriasis, stimulates renal synthesis of 1,25-dihydroxyvitamin D in rats. 1,25-Dihydroxy vitamin D can also reduce the activity of psoriasis...
Articles
Clin Sci (Lond) (1993) 84 (6): 675–679.
Published: 01 June 1993
...Yilmaz Cakaloglu; George Marinos; Joanne Marsden; Timothy J. Peters; Roger Williams; J. Michael Tredger 1. Cyclosporin A absorption was examined after the instillation of approximately 2 mg/kg into four segments (mean length 15 cm) of rat small bowel, isolated in situ in fed Wistar female rats: SI...
Articles
Clin Sci (Lond) (1992) 83 (2): 179–182.
Published: 01 August 1992
...Ersin Yaris; Meral Tuncer; Mustafa Ilhan 1. We studied the in vitro and direct effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation, phenylephrine-induced contraction and drug-induced contraction...
Articles
Clin Sci (Lond) (1992) 82 (2): 119–126.
Published: 01 February 1992
... natriuretic factor in renal transplant recipients. 2. Eight male cyclosporin-treated renal transplant recipients received human-α atrial natriuretic factor (1–28) at a dose of 1.2 pmol min −1 kg −1 or placebo for 2 h in a placebo-controlled, randomized, cross-over study. The plasma atrial natriuretic factor...
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Articles
Clin Sci (Lond) (1990) 79 (3): 259–266.
Published: 01 September 1990
...P. G. McNally; F. Baker; N. Mistry; J. Walls; J. Feehally 1. This study investigates the effect of nifedipine on cyclosporin A nephrotoxicity in the spontaneously hypertensive rat. 2. Cyclosporin A, administered daily by subcutaneous injection at 25 mg/kg body weight for 14 days, induced...
Articles
Clin Sci (Lond) (1990) 79 (2): 149–154.
Published: 01 August 1990
...C. Amorena; A. Castro; A. Müller; M. F. Villamil 1. The contraction and relaxation responses to the polyoxyethylated vehicles currently used for the intravenous and oral administration of cyclosporin A in allograft recipients were studied in isolated rat aorta. The results were compared with those...
Articles
Clin Sci (Lond) (1988) 74 (4): 389–392.
Published: 01 April 1988
... induced by blood transfusions and pregnancy; the maternal alloantibody response to paternal antigens was not increased by an unrelated antigenic stimulus. 3. Immunosuppression with cyclosporin, A was effective in preventing the primary humoral immune response produced by blood transfusion...
Articles
Clin Sci (Lond) (1988) 74 (2): 173–178.
Published: 01 February 1988
...P. H. Whiting; J. G. Simpson 1. Measurements of the rate of lithium clearance, which provides an estimate of proximal renal tubular iso-osmotic reabsorption (i.e. sodium and H 2 O), were used to study H 2 O and electrolyte reabsorption during the development of cyclosporin A (CsA) induced...