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1-19 of 19
Keywords: cystic fibrosis
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Articles
Aliye Uc, Birgitta Strandvik, Jianrong Yao, Xiaoming Liu, Yaling Yi, Xingshen Sun, Ruth Welti, John F. Engelhardt, Andrew W. Norris
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1773–1791.
Published: 13 December 2022
...Aliye Uc; Birgitta Strandvik; Jianrong Yao; Xiaoming Liu; Yaling Yi; Xingshen Sun; Ruth Welti; John F. Engelhardt; Andrew W. Norris Persons with cystic fibrosis (CF) exhibit a unique alteration of fatty acid composition, marked especially among polyunsaturates by relative deficiency of linoleic...
Includes: Supplementary data
Articles
Brahmchetna Bedi, Kuo-Chuan. Lin, Nicholas M. Maurice, Zhihong Yuan, Kaiser Bijli, Michael Koval, C. Michael Hart, Joanna B. Goldberg, Arlene Stecenko, Ruxana T. Sadikot
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1911–1934.
Published: 23 July 2020
...Brahmchetna Bedi; Kuo-Chuan. Lin; Nicholas M. Maurice; Zhihong Yuan; Kaiser Bijli; Michael Koval; C. Michael Hart; Joanna B. Goldberg; Arlene Stecenko; Ruxana T. Sadikot Cystic fibrosis (CF) is a progressive multiorgan autosomal recessive disease with devastating impact on the lungs caused...
Includes: Supplementary data
Articles
Marie-Julie Guichard, David Kinoo, Anne-Sophie Aubriot, Nathalie Bauwens, Jordane Gougué, François Vermeulen, Patrick Lebecque, Teresinha Leal, Rita Vanbever
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (13): 1439–1452.
Published: 18 July 2018
...Marie-Julie Guichard; David Kinoo; Anne-Sophie Aubriot; Nathalie Bauwens; Jordane Gougué; François Vermeulen; Patrick Lebecque; Teresinha Leal; Rita Vanbever Highly viscous mucus and its impaired clearance characterize the lungs of patients with cystic fibrosis (CF). Pulmonary secretions...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1107–1121.
Published: 17 May 2017
...Sabrina Noel; Nadtha Panin; Mathilde Beka; Barbara Dhooghe; François Huaux; Teresinha Leal Chronic inflammation that progressively disrupts the lung tissue is a hallmark of cystic fibrosis (CF). In mice, vardenafil, an inhibitor of phosphodiesterase type 5 (PDE5), restores transepithelial ion...
Includes: Supplementary data
Articles
Lawrence T. McGRATH, Damien McCALL, Colm G. HANRATTY, Siobhan BRENNAN, Adrian DEVINE, Daniel F. McCAULEY, Bernard SILKE, Stuart ELBORN
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (5): 507–513.
Published: 27 September 2001
...Lawrence T. McGRATH; Damien McCALL; Colm G. HANRATTY; Siobhan BRENNAN; Adrian DEVINE; Daniel F. McCAULEY; Bernard SILKE; Stuart ELBORN Heightened systemic oxidative stress is increasingly recognized as a feature of cystic fibrosis (CF). The consequences of long-term exposure to free radical attack...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (4): 309–314.
Published: 07 September 2000
...Sarah L. ELKIN; Lauren WILLIAMS; Margaret MOORE; Margaret E. HODSON; Olga M. RUTHERFORD Few studies have investigated peripheral muscle strength and quality in patients with cystic fibrosis (CF). The present study tested the isometric and isokinetic strength of the quadriceps and hamstrings using...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (3): 277–284.
Published: 01 September 1995
...D. G. Peckham; A. Conn; C. Chotai; S. Lewis; A. J. Knox 1. Airway epithelium in cystic fibrosis is characterized by a defect in chloride secretion across the apical membrane and an increase in sodium absorption. The increased rate of sodium absorption can be inhibited in vitro by ouabain, a Na + -K...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 103–107.
Published: 01 July 1994
... high-fidelity ECG signals from 24 leads, and the electrical variability is expressed as an electrical variability index ranging from 1 to 150. In this study, variance electrocardiography was employed to detect cardiac involvement in 23 patients with cystic fibrosis. 2. Patients with cystic fibrosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (2): 133–139.
Published: 01 February 1994
... the sweating occurred in response to cyclic AMP-elevating agonists, we speculate that the cyclic AMP-activated Cl − channels (the mouse version of the cystic fibrosis transmembrane conductance regulator) may also occur in the mouse sweat gland, but that the degree of their expression may be influenced...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (5): 563–568.
Published: 01 November 1993
...J. Stuart Elborn; Sally M. Cordon; Philip J. Western; Ian A. MaCdonald; Dennis J. Shale 1. We investigated the relationship between circulating tumour necrosis factor-α concentrations, resting energy expenditure, cachexia and altered intermediary metabolism in patients with cystic fibrosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (6): 667–672.
Published: 01 June 1992
...S. N. Smith; E. W. F. W. Alton; D. M. Geddes 1. The basic defect in cystic fibrosis relates to abnormalities of ion transport in affected tissues, such as the respiratory and gastrointestinal tracts. The identification of the cystic fibrosis gene has enabled studies on the production of a cystic...
Articles
E. H. J. van Haren, W. P. M. Hopman, J. B. M. J. Jansen, G. Rosenbusch, C. B. H. W. Lamers, C. L. A. van Herwaarden
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (1): 85–89.
Published: 01 July 1991
...E. H. J. van Haren; W. P. M. Hopman; J. B. M. J. Jansen; G. Rosenbusch; C. B. H. W. Lamers; C. L. A. van Herwaarden 1. In patients with cystic fibrosis, abnormalities in plasma cholecystokinin level and gall-bladder emptying may contribute to the development of maldigestion and gall-stones. 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (4): 299–305.
Published: 01 October 1990
... hyperfiltration in essential fatty acid-deficient rats with the subsequent fall in glomerular filtration rate, which was paralleled by a rise in serum levels of urea and creatinine, as well as the increased non-renal clearance of tobramycin, are in accordance with the clinical manifestations of cystic fibrosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (4): 409–417.
Published: 01 April 1990
... patients with cystic fibrosis and asthma. 2. In carcinoma controls, mean B max. values (± sem ) for airway levels 1 and 11 were 89 ± 4 and 133 ± 6 fmol/mg of protein, respectively ( P <0.01). The corresponding K D values at each airway level were similar, i.e. 29 ± 2 and 33 ± 1 pmol/l, respectively...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1989) 76 (3): 283–287.
Published: 01 March 1989
...Hans-Georg Eichler; Irmgard Eichler; Norman Lewiston; Terrence F. Blaschke; Brian B. Hoffman 1. The basic biochemical defect of cystic fibrosis (CF) remains undetermined, but impaired function of the β-adrenoceptor-mediated adenosine 3′:5′-cyclic monophosphate (cyclic AMP)-dependent regulatory...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (4): 407–410.
Published: 01 October 1987
...Ross D. Feldman; Robert B. Fick; Wendy McArdle; Cynthia C.-Y. Lai 1. β-Adrenergic responsiveness may be decreased in cystic fibrosis. In order to determine whether this reflects an alteration in the human lymphocyte β-receptor complex, we studied 12 subjects with cystic fibrosis (six were stable...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (4): 441–447.
Published: 01 April 1985
.... The composition of thermal and pilocarpine sweat indicates that pharmacological stimulation does not wholely reproduce the physiological mechanism: pilocarpine sweat contains more sodium and more cyclic AMP, irrespective of the secretory rate. 3. The sweat obtained from patients with cystic fibrosis has been...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (5): 445–451.
Published: 01 November 1979
...J. R. Clamp; M. Gough 1. The mucus glycoproteins in meconium from normal infants and from infants having cystic fibrosis with meconium ileus have been studied. 2. Whereas normal meconium contained about 50% protein-bound carbohydrate, the meconium from cystic fibrosis contained only about 10%. 3...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (4): 533–543.
Published: 01 October 1972
... in the former and inversely proportional in the latter case. 4. Sympathomimetic drugs, bradykinin and mucolytic drugs had no effect on the secretory index. 5. In cystic fibrosis, bronchitis and bronchiectasis gland size and not the disease process was the main determinant of the secretory index. 30 5 1972...