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Keywords: cytochrome P450 4A ω-hydroxylase (CYP4A)
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Articles
Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5 BN consomic rats
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Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (5): 333–342.
Published: 16 November 2012
... in the arteries of SS rats. These findings indicate that SS rats have an up-regulation of the CYP4A/20-HETE pathway resulting in elevated ROS (reactive oxygen species) and reduced NO bioavailability causing vascular dysfunction. 20-hydroxyeicosatetraenoic acid (20-HETE) cytochrome P450 4A ω-hydroxylase...