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Keywords: cytoskeleton
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Articles

Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling

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Yingjin Qiao, Pei Wang, Mingyang Chang, Bohan Chen, Yan Ge, Deepak K. Malhotra, Lance D. Dworkin, Rujun Gong
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (7): 695–710.
https://doi.org/10.1042/CS20200016
Published: 30 March 2020
... of NDP-MSH, because Adriamycin-inflicted cytopathic signs in primary podocytes prepared from WT mice were all mitigated by NDP-MSH, including apoptosis, loss of podocyte markers, de novo expression of the podocyte injury marker desmin, actin cytoskeleton derangement and podocyte hypermotility. Consistent...
View articletitled, Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling
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Articles

Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy

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Chang-Yien Chan, Kar-Hui Ng, Jinmiao Chen, Jinhua Lu, Caroline Guat-Lay Lee, Puay-Hoon Tan, Stanley C. Jordan, Henry Yang He, Hui-Kim Yap
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (24): 2317–2327.
https://doi.org/10.1042/CS20160312
Published: 15 November 2016
... cytoskeleton remodelling. Immunofluorescence examination demonstrated glomerular expression of Vav1 in rats which co-localized with synaptopodin, confirming podocyte expression. However, positive staining for the phosphorylated form of Vav1 (p-Vav1) was only seen in IL-13 -overexpressed rats. Moreover...
View articletitled, Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy
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Includes: Supplementary data