... activity and superoxide production during phagocytosis. The immunodeficiency in inherited ADA deficiency was related to a defect in this process. 2. Since there is considerable interspecies variation in the tissue distribution of xanthine oxidase, the metabolism of [8- 14 C]deoxyadenosine (dAR), the toxic...

... deficiency; deoxyadenosine in adenosine deaminase deficiency, the latter having previously been identified erroneously as adenine after degradation in the acidic conditions used. 3. Deoxyriboside excretion was specific for the two defects associated with immunodeficiency; adenine for adenine...