...R. B. Jones; J. Patrick; P. J. Hilton 1. Sodium transport and intracellular sodium content were studied in thymocytes of rats made hypertensive by treatment for 4 or 8 weeks with deoxycorticosterone (DOC) and salt (DOC/salt). 2. The systolic blood pressure in the DOC/salt animals was 152 ± sem 3...

...M. F. Villamil; C. Amorena; J. Ponce; A. Müller; A. C. Taquini 1. Sequential changes in the ionic composition of the aorta and skeletal muscle were followed during 1, 2 and 4–6 weeks in 30 rats given deoxycorticosterone (DOC) and salt supplemented with potassium chloride. Twenty-one rats, drinking...

...E. G. Biglieri; B. Chang; J. Hirai; N. Brust; C. R. Rost; M. Schambelan 1. Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient...

...O. B. Holland; C. Gomez-Sanchez; T. Ziegler 1. The Carworth Long-Evans rat has been reported to develop adrenal-regeneration hypertension but not deoxycorticosterone acetate (DOCA) hypertension. Deficiency of a hypothalamic receptor for deoxycorticosterone which mediates saline polydipsia has been...

...Julia H. Hauger-Klevene; P. Vecsei 1. The free deoxycorticosterone pool in the rat was measured by means of a radioimmunoassay in vivo. 2. The free deoxycorticosterone pool in rats with adrenal regeneration with normal or high blood pressure was similar. 3. In rats with adrenal regeneration...

...J. M. Terris; K. H. Berecek; E. L. Cohen; J. C. Stanley; W. M. Whitehouse, Jr; D. F. Bohr 1. Deoxycorticosterone acetate (DOCA) implantation (100 mg/kg) caused mean arterial pressure to rise in 5–10 days from control pressures of 100–115 mmHg to stable hypertensive valnes of 140–160 mmHg...

...F. S. Goldby 1. The arteriolar lesions of rats with deoxycorticosterone (DOCA)—salt hypertension have been studied by colloidal carbon injection and light- and electron-microscopy. 2. Colloidal carbon particles enter the media of arterioles to form focal deposits when hypertension develops. 3...

... in undiluted plasma, [ 3 H]aldosterone and rat kidney slices. Thus plasma binding and receptor occupancy can be simultaneously considered. 2. Competitor activities relative to that of aldoterone (100%) were: deoxycorticosterone (DOC), 16%; Cortisol, 0·4%; 18-hydroxydeoxycorticosterone (18-OH-DOC), 0·1%; 16β-OH...

...J. Möhring; B. Möhring; M. Petri; D. Haack 1. The role of arginine-vasopressin in the pathogenesis of malignant deoxycorticosterone (DOC) hypertension of rats was investigated. 2. In rats with malignant DOC hypertension plasma arginine-vasopressin concentrations increased more than tenfold...

...D. J. Pugsley; Rachel Mullins; L. J. Beilin 1. The role of renal medullary prostaglandin E has been examined in rats with hypertension induced by sodium chloride and deoxycorticosterone (salt—DOC). 2. Synthesis of prostaglandin E was normal in early salt—DOC hypertension. Indomethcin exacerbated...

...P. J. Lewis; H. J. Dargie; C. T. Dollery 1. The mechanism by which pretreatment of rats with intracisternal 6-hydroxydopamine prevents the onset of deoxycorticosterone hypertension has been studied. 2. Rats pretreated with central 6-hydroxydopamine increase their consumption of 0.17 mol/l sodium...

...C. L. Cope; S. Loizou 1. Radioimmunoassay has been used to detect and estimate the urinary excretion of deoxycorticosterone (DOC) in normal, hypertensive and hypokalaemic subjects. The range of excretions in ten healthy normal subjects was 41–232 pmol (13.7–76.7 ng) daily, with a mean of 124 pmol...

... with congenital diabetes insipidus were used. The infusion of hypotonic saline resulted in a progressive rise in free water clearance ( C H 2 O ) throughout the range of urine flow ( V ) attained. Similar results were obtained in rats treated chronically with deoxycorticosterone acetate (DOCA). The infusion...

... sodium, total body water, extracellular fluid and plasma volumes are reduced; total exchangeable and total body potassium, plasma renin and angiotensin II concentrations are increased. 3. Spironolactone is similarly effective in patients with apparently isolated deoxycorticosterone (DOC) excess; also...

...L. J. Beilin; G. Ziakas 1. The mechanism by which the blood pressure remains elevated after temporary administration of deoxycorticosterone (DOCA) and saline has been studied by comparing vascular reactivity in the resistance bed of the isolated perfused rat tail in animals with post-DOCA...

... with deoxycorticosterone (20 mg/day; seven subjects), or spironolactone (200 mg/day; eight subjects), for 1 day before the day of study. 2. Treatment with deoxycorticosterone significantly ( P < 0·01) decreased sodium excretion (from a mean value of 391 to 192 μEq/min) and urine flow rate (from 14·3 to 12·4 ml min −1...