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Keywords: desensitization
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Articles
Clin Sci (Lond) (2001) 100 (4): 451–457.
Published: 20 March 2001
...Anita ZETTERLUND; Paul HJEMDAHL; Kjell LARSSON In vitro studies suggest that glucocorticoids may counteract β-agonist-induced desensitization of β-adrenoceptors by actions at the transcriptional level, but the clinical relevance of such findings is not clear. Oral terbutaline treatment decreases β...
Articles
Clin Sci (Lond) (1999) 96 (3): 253–259.
Published: 01 March 1999
... treatment. The PD 20 values were log-transformed and calculated as change from baseline. Percentage desensitization of log PD 20 for first- versus last-dose bronchoprotection was calculated and analysed according to effects of treatment and β 2 -adrenoceptor polymorphism at codon 16 or 27. The mean degree...
Articles
Clin Sci (Lond) (1993) 84 (2): 151–157.
Published: 01 February 1993
... stimulation. 2. Prior incubation of cells with varying concentrations of isoprenaline (1–16 h), forskolin, prostaglandin E 2 or a stable analogue of cyclic AMP all produced concentration-related desensitization of cyclic AMP responses to subsequent challenge with isoprenaline (maximum reduction with 1 μmol/l...
Articles
Clin Sci (Lond) (1987) 72 (1): 47–54.
Published: 01 January 1987
... © 1970 The Biochemical Society and the Medical Research Society 1970 β-adrenoceptor desensitization lymphocytes plasma cyclic AMP plasma isoprenaline resensitization CIinicalScience(1987) 7 2 , 47-54 47 Studies in vivo and in vitro of terbutaline-induced p -adrenoceptor desensitization in...
Articles
Clin Sci (Lond) (1986) 70 (2): 147–153.
Published: 01 February 1986
... catecholamines with α 2 agonist activity in vivo produced attenuation of the platelet responses to adrenaline in vitro. This desensitization was specific for the adrenaline induced aggregatory response. 3. The maximum number of [ 3 H]yohimbine binding sites on platelets was not altered by adrenaline infusion. 4...
Articles
Clin Sci (Lond) (1985) 68 (s10): 129s–132s.
Published: 01 January 1985
... ; conversely an increase in activity was observed postoperatively in two patients after removal of phaeochromocytoma. 4. The changes in platelet response were not accompanied by changes in α 2 -adrenoceptor number. 5. It is proposed that a process of receptor inactivation occurs during desensitization and this...