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Keyword: developmental programming
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Articles
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins of...
Articles
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
... potential molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated...
Articles
Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
...Saleh H. Alwasel; David J. P. Barker; Nick Ashton Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero ) model of developmental programming because of increased renal NKCC2 (Na + /K + /2Cl − co-transporter 2...
Articles
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... jhc36@cam.ac.uk ). 27 4 2010 4 6 2010 8 6 2010 8 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 developmental programming lifespan maternal diet renal function senescence stress response Aging is a biological process that is...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 118 (6): 429–438.
Published: 14 December 2009
... contribute to the regulation of longevity by maternal diet. Correspondence: Dr Jian-Hua Chen (email jhc36@cam.ac.uk ). 13 8 2009 6 10 2009 29 10 2009 29 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 developmental programming...
Articles
Clin Sci (Lond) (2009) 117 (2): 85–93.
Published: 15 June 2009
... Journal compilation © 2009 Biochemical Society 2009 developmental programming energy balance hypothalamic neuropeptide lactation obesity pregnancy Over recent decades, there has been a large increase in the proportion of both adults and children that are either overweight or obese in...
Articles
Clin Sci (Lond) (2008) 114 (1): 1–17.
Published: 30 November 2007
... developmental programming hypertension perinatal environment vascular dysfunction The prevalence of obesity, Type 2 diabetes and hypertension, which are major risk factors for cardiovascular-system-related morbidity and mortality, has increased substantially in many countries over the last two...