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Keywords: developmental programming
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Articles
Maria Florencia Albertoni Borghese, Lucas Humberto Oronel, Maria Del Carmen Ortiz, Mónica Patricia Majowicz
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1303–1339.
Published: 08 September 2022
... in the developmental programming of hypertension and renal disease. The purpose of this review is to highlight the great number of studies, most of them performed in animal models, showing the broad range of stressors involved in hypertension and renal disease programming, with a particular focus on the stressors...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 711–714.
Published: 16 May 2022
...Mark Hedley Vickers A clear link has been established between alterations in the early life environment and the risk for developing a range of cardiometabolic diseases in later life, a process preferentially termed developmental programming. In particular, alterations in the maternal nutritional...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... to the developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
... molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
...Saleh H. Alwasel; David J. P. Barker; Nick Ashton Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero ) model of developmental programming because of increased renal NKCC2 (Na + /K + /2Cl − co-transporter 2...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... (copper/zinc superoxide dismutase) and Sesn1 (sestrin 1) in the kidneys of recuperated offspring suggest that protein homoeostasis and resistance to oxidative stress are compromised, leading to accelerated cellular senescence in these shorter-lived mice. developmental programming lifespan maternal...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (6): 429–438.
Published: 14 December 2009
... until analysis. developmental programming immunosenescence lifespan maternal diet thymic growth thymic involution It is well known that early growth patterns can have profound long-term effects on later health. Epidemiological studies first demonstrated a close link between low...
Articles
Roselle L. Cripps, Malgorzata S. Martin-Gronert, Zoe A. Archer, C. Nick Hales, Julian G. Mercer, Susan E. Ozanne
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (2): 85–93.
Published: 15 June 2009
... Journal compilation © 2009 Biochemical Society 2009 developmental programming energy balance hypothalamic neuropeptide lactation obesity pregnancy Over recent decades, there has been a large increase in the proportion of both adults and children that are either overweight or obese...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (1): 1–17.
Published: 30 November 2007
... developmental programming hypertension perinatal environment vascular dysfunction The prevalence of obesity, Type 2 diabetes and hypertension, which are major risk factors for cardiovascular-system-related morbidity and mortality, has increased substantially in many countries over the last two...