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Keywords: developmental programming
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Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
... focuses largely on the developmental programming of cardiovascular function and begins with a brief discussion on the emergence of the ‘Barker hypothesis’, and its subsequent evolution into the more-encompassing DOHaD framework. We then discuss some fundamental pathophysiological processes by which...
Clin Sci (Lond) (2016) 130 (5): 337–348.
Published: 26 January 2016
... to the developmental programming of increased cardiovascular risk. Numerous epidemiological studies support the link between influences during early life and later cardiovascular health; experimental models provide proof of principle and indicate that numerous mechanisms contribute to the developmental origins...
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
... molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy...
Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
...Saleh H. Alwasel; David J. P. Barker; Nick Ashton Sodium retention has been proposed as the cause of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero ) model of developmental programming because of increased renal NKCC2 (Na + /K + /2Cl − co-transporter 2...
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... (Promega) with oligo(dT) 15 as the primer, according to the manufacturer's protocol. developmental programming lifespan maternal diet renal function senescence stress response Aging is a biological process that is accompanied by a progressive decline in physiological functions, leading...
Includes: Supplementary data
Clin Sci (Lond) (2010) 118 (6): 429–438.
Published: 14 December 2009
... RNA using an ImProm-II Reverse Transcription System (Promega) with oligo(dT) 15 as the primer, according to the manufacturer's protocol. developmental programming immunosenescence lifespan maternal diet thymic growth thymic involution It is well known that early growth patterns can...
Clin Sci (Lond) (2009) 117 (2): 85–93.
Published: 15 June 2009
... 2009 Biochemical Society 2009 developmental programming energy balance hypothalamic neuropeptide lactation obesity pregnancy All procedures involving animals were carried out under the U.K. Home Office Animals (Scientific Procedures) Act, 1986. Many of the diseases where obesity...
Clin Sci (Lond) (2008) 114 (1): 1–17.
Published: 30 November 2007
.... Correspondence: Dr Anne Monique Nuyt (email anne-monique.nuyt@recherche-ste-justine.qc.ca ). 2 4 2007 17 5 2007 30 5 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 blood pressure cardiovascular disease developmental programming hypertension perinatal...