...) is expressed in GLP-1-producing cells, where GR activation in response to dexamethasone induces SGK1 (serum- and glucocorticoid-inducible kinase 1) expression, but did not influence preproglucagon expression or cell viability. In addition, dexamethasone treatment of enteroendocrine GLUTag cells reduced GLP-1...

... to inhaled histamine. Both responses were abolished by treatment with either dexamethasone (20 mg/kg of body weight, subcutaneous, once a day) or fluticasone propionate (a 0.5 mg/ml solution aerosolized and inhaled over 15 min, twice a day). In ovalbumin-sensitized guinea-pigs, allergen (ovalbumin) challenge...

... have been reported. In the present study we investigated the effects of dexamethasone on EFS (electrical field stimulation)-induced NO release in MAs from WKY (Wistar–Kyoto) rats and SHRs (spontaneously hypertensive rats) and the role of PKC (protein kinase C) in this response. In endothelium-denuded...

... recordings immediately before and after rescue medication (oxygen, dexamethasone and acetazolamide). Forty-seven subjects had measurements at baseline, 39 (21 receiving magnesium and 18 placebo) at altitude I and 26 (13 receiving magnesium and 13 placebo) at altitude II. During hyperventilation, MCAv...

... 2003 dexamethasone glucocorticoid receptor L6 myotubes sera from septic rats Clinical Science (2003) 105, 383 391 (Printed in Great Britain) 383 Sepsis induces the transcription of the glucocorticoid receptor in skeletal muscle cells Xiaoyan SUN Joshua M. V. MAMMEN and Xintian TIAN...

... de la Nutrition, Faculté de Pharmacie, 4, avenue de l'Observatoire, 75270 PARIS Cedex 06, France (e-mail [email protected] ). 14 5 2001 10 9 2001 25 10 2001 The Biochemical Society and the Medical Research Society © 2002 2002 arginine chemotaxis dexamethasone...

... not been well explored. We hypothesized that this synthetic colloid substance, which maintains colloid osmotic pressure and potentially ‘seals’ capillary leaks, in combination with an anti-inflammatory agent (i.e. dexamethasone), would ameliorate I/R lung injury. After 60 min of lung ischaemia...

... exposed to dexamethasone for only 2 days at 27 days of gestation (term ≈ 150 days) became hypertensive adults, whereas those exposed at 64 days of gestation remained normotensive, as did controls. In the same sheep, now nearly 5 years old, we performed glucose tolerance tests and hyperinsulinaemic...

... diseases later in life. We were the first to show that sheep exposed to dexamethasone (0.28 mg⋅kg -1 ⋅day -1 for only 2 days) at the end of the first month of pregnancy (PTG1), but not those exposed at the end of the second month of pregnancy (PTG2), had a higher basal mean arterial pressure (MAP) 19...

... and tissue (muscle and intestine) concentrations was also explored. The catabolic model used consisted of injections of dexamethasone (DEX; 1.5 mg⋅day -1 ⋅kg -1 ) for 5 days. As previously described, DEX suppressed TNFα secretion in stimulated macrophages. Supplementation with arginine or OKG...

... involved in producing ischaemia–reperfusion-associated lung vascular injury. 2. The present study modified University of Wisconsin solution (UW) by adding one of the protective agents prostaglandin E 1 (PGE 1 ), dexamethasone (Dex) or dibutyryl cAMP (Bt 2 -cAMP), or a combination of these, to the perfusate...

... blood pressure two groups of pregnant ewes were transported from the farm to the Institute at either 22–29 days of pregnancy (pretreatment group 1) or 59–66 days of pregnancy (pretreatment group 2), subjected to 48 h treatment with dexamethasone (0.28 mg day −1 kg −1 for 2 days) and then returned...

...James P. Codde; Lawrence J. Beilin 1. This study was designed to examine the effect of dexamethasone treatment on tissue and urinary prostanoids, and to determine whether inhibition of prostaglandin biosynthesis by manipulation of dietary fatty acids accelerates the development of glucocorticoid...

...Bernd Rosenkrantz; Aniko Náray-Fejes-Tóth; Geza Fejes-Tóth; Christine Fischer; Masafumi Sawada; Jürgen C. Frölich 1. Dexamethasone was administered to six healthy female volunteers for 4 days, resulting in plasma levels of 4.8 ± 1.4 × 10 −8 mol/l. Urinary excretions of six prostanoids as well...

... A (1.2 mg/ml). 3. The release was inhibited in a concentration-dependent manner by incubation of the cells with dexamethasone (1 nmol/l to 1 μmol/l). 21 5 1984 2 7 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 dexamethasone human alveolar macrophages...

... vehicle (1% NaCl, 0.5 ml), aldosterone (30 μg/kg) or dexamethasone (60 μg/kg). Renal cortical and myocardial ATPase activities were determined 21 days later in all groups. 3. Adrenalectomized WKY rats had reduced myocardial ATPase activity (5.15 ± 0.88 vs 8.18 ± 0.93 μmol of phosphate h −1 mg −1...

...José M. López; Eugenio Arteaga; José A. Rodriguez; Héctor Croxatto 1. The effect of dexamethasone administration for 3 days on urinary kallikrein excretion was studied in 12 normal men with normal sodium intake ( n =6) or low sodium intake ( n =6). Urinary excretion of sodium, potassium, 17...

...C. P. Vio; J. S. Roblero; H. R. Croxatto 1. The effect of d-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. 2. Animals received d-aldosterone or dexamethasone (10 μg/100 g body weight) daily for 3 days...

...M. E. Rafestin-Oblin; C. Roth-Meyer; M. Claire; A. Michaud; E. Baviera; J. M. Brisset; P. Corvol 1. The presence of high-affinity sites for [ 3 H]-aldosterone was shown in the normal human renal tissue. 2. [ 3 H]Aldosterone and [ 3 H]dexamethasone binding were studied in human renal adenocarcinoma...

... of aldosterone in the two groups was not modified by the administration of propranolol, apparently excluding a renin-dependent mechanism. On the other hand, dexamethasone seemed to affect the response of aldosterone to the upright posture in both groups; in adenoma there was a slight but significant increase...

... with the steroid ratio. 4. Dexamethasone treatment of one patient in an attack resulted in significant reductions in excretion of the individual 17-oxosteroids and of porphyrins and porphyrin precursors. This was accompanied by a noticeable improvement in his clinical condition. 5. A series of three C 18 , twelve...