...M. Sutters; C. Brace; E. Hatfield; A. Whitehurst; S. L. Lightman; W. S. Peart 1. We have studied the response of six patients with cranial diabetes insipidus and six age-matched control subjects to dietary sodium restriction during constant administration of the synthetic vasopressin analogue...

... 1993 Brattleboro rat 1-desamino-8- d -arginine vasopressin diabetes insipidus fluid balance servo-system Clinical Science (1993) 85, 129-137 (Printed in Great Britain) I 29 A novel computerdriven, servMontrolled fluid replacement technique and i ts application to renal function studies...

... in female Brattleboro rats with diabetes insipidus (DIHO) and compared with that in female, age matched, heterozygous Long Evans controls (LEHE). 2. Ten DIHO and ten LEHE rats had a normal sodium intake. In ten DIHO rats a 0.16% NaCl solution was supplied instead of drinking water for either 8 days ( n = 5...

...D. G. Shirley; S. J. Walter; J. F. Laycock 1. Brattleboro rats with hereditary diabetes insipidus were maintained in metabolism cages for 12–14 days. During the final 5–7 days hydrochlorothiazide was added to the food of half the animals, resulting in a sustained antidiuresis. At the end...

...S. J. Walter; J. Skinner; J. F. Laycock; D. G. Shirley 1. The antidiuretic effect of hydrochlorothiazide in diabetes insipidus was investigated in rats with the hereditary hypothalamic form of the disease (Brattleboro rats). 2. Administration of hydrochlorothiazide in the food resulted in a marked...

... in urine volume by more than fourfold was associated with a slight increase in urinary excretion of prostaglandin E 2 from 466 ± 66 to 1017 ± 174 pmol/24 h ( P = 0.05). 2. In five patients with central diabetes insipidus mean urine volume of 10 838 ± 107 ml/24 h was reduced to 1205 ± 204 ml/24 h ( P...

...S. J. Walter; J. F. Laycock; D. G. Shirley 1. Renal function in anaesthetized Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied with micropuncture techniques before, and 1–3 h after, a single injection of hydrochlorothiazide. 2. In rats given hydrochlorothiazide and kept...

...H. Dlouhá; J. Křeček; J. Zicha 1. In rats with inherited diabetes insipidus, unilateral nephrectomy plus drinking of 0·6% NaCl solution (saline) did not influence blood pressure in adult rats. However, when these factors applied before puberty, they produced hypertension. 2. We therefore analysed...

...D. G. Shirley; S. J. Walter; J. F. Laycock 1. The mechanism of the antidiuretic effect of hydrochlorothiazide in diabetes insipidus was studied in anaesthetized Brattleboro rats with the hereditary hypothalamic form of the disease. 2. The antidiuresis caused by acute administration...