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Keyword: diabetes mellitus
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Articles
Clin Sci (Lond) (2016) 130 (20): 1823-1836.
Published: 15 September 2016
... the treatment with the PPARβ/δ agonist GW0742 prevents the hyperglycaemic-induced impairment of cAMP-mediated relaxation. This protective effect is associated with the preservation of Kv7 channel function. cAMP coronary circulation diabetes mellitus potassium channels PPARβ/δ...
Articles
Clin Sci (Lond) (2016) 130 (13): 1105-1114.
Published: 23 May 2016
... hormonal disturbances. In the present study, we show the adipose tissue of obese subjects to be less sensitive to atrial natriuretic peptide, a cardiac hormone important during exercise. adipose tissue diabetes mellitus type 2 lipolysis natriuretic peptides obesity • Regarding adipose...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (4): 269-280.
Published: 17 October 2014
... inflammatory and oxidative stress responses both in cultured renal tubular cells exposed to advanced glycation end-products and in diabetic db / db mice. advanced glycation end-product diabetes mellitus db / db mice renal tubular cell • ESRD from T2DN imposes a heavy burden on most...
Articles
Clin Sci (Lond) (2014) 127 (7): 499-505.
Published: 17 June 2014
...-blind randomized clinical trial demonstrates that treatment with high-dose folic acid fails to reduce oxidant stress and albuminuria in human subjects with incipient diabetic nephropathy. Novel treatment options for this condition are urgently needed. circulation complications diabetes mellitus...
Articles
Clin Sci (Lond) (2014) 127 (7): 485-497.
Published: 17 June 2014
... evaluating aortic plaque accumulation and necrotic core formation within the relevant BM-transplanted chimaeras. atherosclerosis bone marrow transplantation diabetes mellitus mouse model receptor for advanced glycation end-products (RAGE) • Increased RAGE activation has been implicated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 121 (7): 305-312.
Published: 07 June 2011
...Ting-I Lee; Yu-Hsun Kao; Yao-Chang Chen; Nan-Hung Pan; Yung-Kuo Lin; Yi-Jen Chen Hypertension and DM (diabetes mellitus) are common chronic disorders that often co-exist. DM and PPAR (peroxisome-proliferator-activated receptor)-γ agonists may directly impair heart function. However, the effects of...
Articles
Clin Sci (Lond) (2010) 119 (10): 423-429.
Published: 05 August 2010
...Martin G. Lazenby; Martin A. Crook About a decade ago, a hypothesis was proposed suggesting that the innate immune system, including acute-phase reactants, contribute to the development of T2DM [Type 2 DM (diabetes mellitus)] and the metabolic syndrome. In this model, it was hypothesized that the...
Articles
Clin Sci (Lond) (2010) 119 (6): 225-238.
Published: 08 June 2010
... Biochemical Society 2010 arteriogenesis collateral circulation diabetes mellitus endothelium peripheral arterial disease vascular smooth muscle DM is recognized as a major cardiovascular risk factor. PAD is a common vascular complication in the diabetic population, as diabetes increases the...
Articles
Clin Sci (Lond) (2008) 114 (2): 109-118.
Published: 11 December 2007
... of DN. From clinical studies of Type 1 and Type 2 diabetes mellitus, it is clear that many patients do not have early hyperfiltration and, even when present, its contribution to subsequent DN remains uncertain. Key mechanisms underlying hyperfiltration in rodent models are reviewed. Findings on...
Articles
Clin Sci (Lond) (2006) 110 (6): 665-671.
Published: 15 May 2006
..., but this did not influence myocardial infarct size. Correspondence: Dr Troels Thim (email troels.thim@ki.au.dk ). 26 10 2005 5 1 2006 31 1 2006 31 1 2006 The Biochemical Society 2006 diabetes mellitus diet ischaemia/reperfusion injury metabolic syndrome...
Articles
Clin Sci (Lond) (2005) 109 (2): 143-159.
Published: 25 July 2005
... ). 19 1 2005 15 3 2005 11 5 2005 The Biochemical Society 2005 diabetes mellitus endothelial dysfunction hyperglycaemia insulin resistance metabolic syndrome oxidative stress vascular complication Diabetes mellitus is a common metabolic disease worldwide affecting...
Articles
Clin Sci (Lond) (2004) 106 (5): 527-533.
Published: 01 May 2004
... © 2004 The Biochemical Society 2004 airway surface liquid diabetes mellitus glucose hyperglycaemia nasal Clinical Science (2004) 106, 527 533 (Printed in Great Britain) 527 Effect of hyperglycaemia on glucose concentration of human nasal secretions David M. WOOD , Amanda L. BRENNAN , Barbara...
Articles
Clin Sci (Lond) (2004) 106 (1): 53-60.
Published: 01 January 2004
...Zhi You FANG; Rodel LEANO; Thomas H. MARWICK Subclinical left ventricular (LV) dysfunction may be identified by reduced longitudinal contraction. We sought to define the effects of subclinical LV dysfunction on radial contractility in 53 patients with diabetes mellitus with no LV hypertrophy...
Articles
Clin Sci (Lond) (2003) 105 (5): 591-599.
Published: 01 November 2003
... Biochemical Society 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 591 599 (Printed in Great Britain) 591 Subclinical left ventricular dysfunction in asymptomatic patients with Type II diabetes mellitus, related to serum lipids and...
Articles
Clin Sci (Lond) (2003) 105 (5): 537-540.
Published: 01 November 2003
... © 2003 The Biochemical Society 2003 diabetes mellitus stress echocardiography tissue Doppler ventricular function Clinical Science (2003) 105, 537 540 (Printed in Great Britain) 537 C O M M E N T Ventricular dysfunction in early diabetic heart disease: detection, mechanisms and significance A...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 424S-429S.
Published: 01 September 2002
...Eugene L. BEK; Marvin A. MCMILLEN; Paul SCOTT; L. D. George ANGUS; Gerald W. SHAFTAN In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization...
Articles
Clin Sci (Lond) (2002) 102 (2): 187-194.
Published: 03 January 2002
... angiogenesis atherosclerosis diabetes mellitus growth substances von Willebrand factor. 187Clinical Science (2002) 102, 187 194 (Printed in Great Britain) Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or Type II...
Articles
Clin Sci (Lond) (2001) 101 (6): 671-679.
Published: 21 November 2001
... difficult in the absence of diabetes-specific risk equations. The model for CHD risk in Type II diabetes Key words: coronary disease, diabetes mellitus, models, non-insulin-dependent, statistical. Abbreviations : CHD, coronary heart disease ; DCCT, Diabetes Control and Complications Trial ; GDM, Global...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2001) 101 (5): 523-531.
Published: 03 October 2001
...Annika DOTEVALL; Johannes HULTHE; Annika ROSENGREN; Olov WIKLUND; Lars WILHELMSEN Women with diabetes mellitus are at high risk of myocardial infarction (MI), and it is well recognized that smoking, hypertension, hyperlipidaemia and the diabetic state itself do not fully explain this increased risk...
Articles
Clin Sci (Lond) (2001) 101 (3): 261-266.
Published: 03 August 2001
..., Manchester M20 8LB, U.K. (e-mail annelcarr@netscapeonline.co.uk ). 12 1 2001 17 4 2001 17 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 amputee diabetes mellitus nerve oxygen peripheral vascular 261Clinical Science (2001) 101, 261 266...
Articles
Clin Sci (Lond) (2001) 100 (1): 13-17.
Published: 05 December 2000
... Green (e-mail brevis@cyllene.uwa.edu.au ). 4 5 2000 13 7 2000 7 9 2000 The Biochemical Society and the Medical Research Society © 2001 2001 angiotensin receptor blockade diabetes mellitus endothelium flow-mediated dilation nitric oxide nitroglycerine 13Clinical...
Articles
Clin Sci (Lond) (2000) 99 (5): 383-392.
Published: 03 October 2000
...R. Andrew P. SKYRME-JONES; Richard C. O'BRIEN; Ian T. MEREDITH We and others have previously documented increased resting and exercise-induced skeletal muscle blood flow in young subjects with Type I (insulin-dependent) diabetes mellitus compared with healthy controls. Both NO and prostanoids are...
Articles
Clin Sci (Lond) (2000) 98 (3): 355-363.
Published: 10 February 2000
... retinopathy. Correspondence : Dr B. Mackness (e-mail bmack@central.cmht.nwest.nhs.uk ). 26 7 1999 27 10 1999 9 12 1999 The Biochemical Society and the Medical Research Society © 2000 2000 diabetes mellitus paraoxonase polymorphisms retinopathy 355Clinical Science (2000...
Articles
Clin Sci (Lond) (2000) 98 (2): 175-181.
Published: 11 January 2000
... with ischaemic heart disease ( n = 80), cardiac arrhythmia ( n = 60), diabetes mellitus ( n = 36), essential hypertension ( n = 194) and hypercholesterolaemia ( n = 60). The same measurements were made in healthy controls (30 men and 26 women; mean age 58±11 years). The serum ionized Mg concentration...
Articles
Clin Sci (Lond) (1999) 97 (2): 149-156.
Published: 16 June 1999
... patients with diabetes is associated with their total insulin exposure to see if plasma ET-1 might be a link between insulin exposure and long-term complications of diabetes. We studied 69 patients with Type I and 40 patients with Type II diabetes mellitus in equally tight glycaemic control for 2 years in...
Articles
Clin Sci (Lond) (1999) 96 (3): 221-230.
Published: 01 March 1999
...Tahseen A. CHOWDHURY; Philip H. DYER; Sudhesh KUMAR; Anthony H. BARNETT; Stephen C. BAIN Diabetic nephropathy is the most serious complication of diabetes mellitus. Progression of the condition leads to end-stage renal failure, and other complications of diabetes are also common in this group of...
Articles
Clin Sci (Lond) (1998) 95 (3): 317-323.
Published: 01 September 1998
...Anders O. BJÖRKLUND; Ulf K. C. ADAMSON; Per-Eric S. LINS; L. Magnus R. WESTGREN 1. Intensive insulin treatment of patients with Type I diabetes mellitus during pregnancy is associated with a high frequency of serious hypoglycaemic events. A potential change in insulin metabolism during pregnancy...
Articles
Clin Sci (Lond) (1998) 94 (6): 623-632.
Published: 01 June 1998
...Rakesh Kakkar; Subrahmanyam V. Mantha; Jasim Radhi; Kailash Prasad; Jawahar Kalra 1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. There are many reports indicating the changes in parameters of oxidative stress in diabetes mellitus. In...
Articles
Clin Sci (Lond) (1998) 94 (2): 157-163.
Published: 01 February 1998
... diabetes mellitus hypoglycaemia lactate Clinical Science (1998) 94, 157- I63 (Printed in Great Britain) I57 Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus P. KING, M.4. KONG, H. PARKIN*, 1. A. MACDONALD*, C. BARBERt and R. 6. TATTERSALL...
Articles
Clin Sci (Lond) (1998) 94 (1): 65-70.
Published: 01 January 1998
... between changes in blood pressure and the rate of gastric emptying after ingestion of 75 g of glucose in patients with noninsulin-dependent diabetes mellitus (NIDDM) and both young and older normal subjects. Sixteen patients with recently diagnosed NIDDM, median age 57 (39–79) years, 10 ‘young’ subjects...
Articles
Clin Sci (Lond) (1997) 93 (4): 325-333.
Published: 01 October 1997
... the Medical Research Society 1997 cardiovascular autonomic function diabetes mellitus m -[ 123 I]iodobenzylguanidine heart rate QT interval single-photon emission computed tomography spectral analysis Clinical Science (1997) 92, 325-333 (Printed in Great Britain) 325 Evaluation of QT...
Articles
Clin Sci (Lond) (1997) 93 (4): 335-341.
Published: 01 October 1997
...Qiuping Zhang; Elisabeth Cavallero; Michael M. Hoffmann; Julian Cavanna; Andrea Kay; Aline Charles; Sylvie Braschi; Winfried Marz; Leon Perlemuter; Bernard Jacotot; David J. Galton 1. The common association of obesity, diabetes mellitus and hyperlipidaemia may have a primary aetiological basis...
Articles
Clin Sci (Lond) (1997) 93 (2): 147-152.
Published: 01 August 1997
... Research Society 1997 diabetes mellitus fetal physiology hypertension insulin resistance syndrome Clinical Science (1997) 93, 147-152 (Printed in Great Britain) I47 Early protein restriction and obesity independently induce hypertension in I -year-old rats Clive. J. PETRY*, Susan E. OZANNE...
Articles
Clin Sci (Lond) (1996) 91 (5): 575-582.
Published: 01 November 1996
... glyoxalase system with reduced glutathione as co-factor. The concentration of reduced glutathione may be decreased by oxidative stress and by decreased in situ glutathione reductase activity in diabetes mellitus. A reduced concentration of reduced glutathione may predispose diabetic patients to oxidative...
Articles
Clin Sci (Lond) (1996) 90 (5): 379-384.
Published: 01 May 1996
... oxide l-arginine diabetes mellitus nitric oxide synthase inhibitor nitrate nitrite streptozotocin Clinical Science (1996) 90, 37W84 (Printed in Great Britain) 379 Nitric oxide in streptozotocin-induced diabetes mellitus in rats Abed MAREE, Gari PEER, Adrian IAINA, Miriam BLUM, Yoram WOLLMAN...
Articles
Clin Sci (Lond) (1995) 89 (6): 557-564.
Published: 01 December 1995
... diabetes mellitus heart rate parasympathetic function Clinical Science (1995) 89. 557-564 (Printed i n Great Britain) 557 On the quantification of heart rate changes in autonomic function tests: relations between measures in beats per minute, seconds and dimensionless ratios The0 J. C. FAES*, Nico N...
Articles
Clin Sci (Lond) (1995) 89 (5): 461-465.
Published: 01 November 1995
...Ole Gøtzsche; Ahmed Darwish; Lars Peter Hansen; Liv Gøtzsche 1. Insulin-dependent diabetes mellitus is a known risk factor for congestive heart failure and an early diastolic dysfunction has been described. In order to see if diabetes itself and not complications like hypertension, nephropathy or...
Articles
Clin Sci (Lond) (1995) 88 (6): 675-679.
Published: 01 June 1995
... cells, cartilage and adipose tissue, but also in plasma. 2. Plasma semicarbazide-sensitive amine oxidase activity was elevated in a group of 104 patients with insulin-dependent diabetes mellitus compared with normal control subjects (555 ± 172 versus 352 ± 102 m-units/l, P < 0.0005). 3. Plasma...
Articles
Clin Sci (Lond) (1995) 88 (5): 519-524.
Published: 01 May 1995
...P. D. Taylor; J. E. Graves; L. Poston 1. There is growing evidence that an impairment in the function of nitric oxide synthase may play a role in the vascular complications of diabetes mellitus. The relaxation of resistance arteries from the mesenteric and hindlimb circulations of streptozotocin...
Articles
Clin Sci (Lond) (1995) 88 (4): 427-432.
Published: 01 April 1995
... 11 1994 5 1 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 continuous ambulatory peritoneal dialysis diabetes mellitus glucose metabolism intraperitoneal insulin insulin action insulin sensitivity serum lipids subcutaneous insulin Clinical...
Articles
Clin Sci (Lond) (1995) 88 (2): 191-196.
Published: 01 February 1995
.... 22 9 1994 12 10 1994 © 1995 The Biochemical Society and the Medical Research Society 1995 diabetes mellitus flow motion laser Doppler flowmetry neuropathy vasomotion Clinical Science (1995) 88, 191-196 (Printed in Great Britain) 191 Flow motion in peripheral diabetic...
Articles
Clin Sci (Lond) (1994) 87 (1): 37-43.
Published: 01 July 1994
...Ronald A. Smulders; Coen D. A. Stehouwer; Cornelis G. Olthof; Gerard J. Van Kamp; Tom Teerlink; Peter M. J. M. De Vries; Ab J. M. Donker 1. Uncomplicated insulin-dependent diabetes mellitus is associated with generalized vasodilatation. This vasodilatation is believed to contribute to the...
Articles
Clin Sci (Lond) (1994) 87 (1): 31-36.
Published: 01 July 1994
... contributory role by permitting alterations in regional haemodynamics. 2. We have studied the contractile behavior of isolated resistance arteries from normotensive patients with insulin-dependent diabetes mellitus and non-diabetic matched control subjects. Contractile responses to potassium (123 mmol/l...
Articles
Clin Sci (Lond) (1994) 86 (4): 383-390.
Published: 01 April 1994
...Carlo Beretta-Piccoli; Francesca Elshater-Zanetti; Sidney Shaw; Daniele Cusi; Peter Weidmann 1. Diabetes mellitus is associated with high body sodium, but the pathogenetic mechanism is still unknown. The possibility that an abnormal renal handling of sodium, an abnormal responsiveness of sodium...
Articles
Clin Sci (Lond) (1994) 86 (3): 257-262.
Published: 01 March 1994
... Society and the Medical Research Society 1994 contractile dysfunction diabetes mellitus myocyte Clinical Science (1994) M, 257-262 (Printed in Great Britain) Contractile dysfunction in the diabetic-rat heart is an intrinsic abnormality of the cardiac myocyte Hideki OKAYAMA, Mareomi HAMADA and...
Articles
Clin Sci (Lond) (1993) 85 (1): 77-81.
Published: 01 July 1993
...C. A. Abbott; M. I. MacKness; S. Kumar; A. O. Olukoga; C. Gordon; S. Arrol; D. Bhatnagar; A. J. M. Boulton; P. N. Durrington 1. The activity of serum butyrylcholinesterase (‘pseudocholinesterase’, EC3.1.1.8) was investigated in 56 patients with type 1 diabetes mellitus, 51 patients with type 2...
Articles
Clin Sci (Lond) (1993) 85 (1): 101-104.
Published: 01 July 1993
... of the eye are probably mediated by autonomic mechanisms which are stimulated by hypoglycaemia. 5 2 1993 6 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 anterior chamber of eye aqueous humour autonomic nervous system diabetes mellitus...
Articles
Clin Sci (Lond) (1993) 84 (4): 469-475.
Published: 01 April 1993
... 4 1 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 N-acetyl-β-D-glucosaminidase alanine aminopeptidase alkaline phosphatase diabetes mellitus dipeptidyl aminopeptidase IV γ-glutamyl transpeptidase non-insulin-dependent diabetes urine Clinical...
Articles
Clin Sci (Lond) (1993) 84 (3): 305-311.
Published: 01 March 1993
... 16 10 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 calcitonin-gene-related peptide cerebrospinal fluid diabetes mellitus diabetic neuropathy nerve biopsy pain painful neuropathy substance P Clinical Science (1993) 84, 305-31 I (Printed in Great...
Articles
Clin Sci (Lond) (1992) 82 (6): 615-618.
Published: 01 June 1992
... the Medical Research Society 1992 cutaneous blood flow diabetes mellitus hypoglycaemia insulin-dependent diabetes Clinical Science (1992) 82, 6 15-6 18 (Printed in Great Britain) Cutaneous blood flow during a hypoglycaemic clamp in insulin-dependent diabetic patients and healthy subjects J...