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Keywords: diabetic cardiomyopathy
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Clin Sci (Lond) (2020) 134 (6): 609–628.
Published: 24 March 2020
... development and has been implicated in cardiovascular diseases. In the present study, we investigated the effects of RXR agonist treatment on streptozotocin (STZ)-induced diabetic cardiomyopathy (DCM) and the underlying mechanism. Sprague–Dawley (SD) rats induced by STZ injection were treated with either RXR...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (10): 897–915.
Published: 04 May 2017
...Mitchel Tate; David J. Grieve; Rebecca H. Ritchie Diabetes increases the risk of heart failure approximately 2.5-fold, independent of coronary artery disease and other comorbidities. This process, termed diabetic cardiomyopathy, is characterized by initial impairment of left ventricular (LV...
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Clin Sci (Lond) (2016) 130 (17): 1511–1521.
Published: 18 July 2016
...Tao Bai; Fan Wang; Yang Zheng; Qiangrong Liang; Yuehui Wang; Jian Kong; Lu Cai Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications in diabetes that increase the mortality of diabetic patients. Mechanisms underlying DCM have not been fully elucidated, hindering targeted...
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Clin Sci (Lond) (2015) 128 (5): 321–323.
Published: 13 November 2014
... in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H 2 S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science , Zhou et al. demonstrate...
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Clin Sci (Lond) (2015) 128 (5): 325–335.
Published: 13 November 2014
...Xiang Zhou; Guoyin An; Xiang Lu There is growing evidence that H 2 S has beneficial effects in treatment of various cardiovascular diseases. However, it remains unclear whether H 2 S can attenuate the development of diabetic cardiomyopathy (DCM). The present study was designed to investigate...
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Clin Sci (Lond) (2014) 126 (7): 471–482.
Published: 06 December 2013
.... Correspondence: Dr Gavin Y. Oudit (email [email protected] ). 1 7 2013 12 9 2013 2 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin-(1–7) angiotensin-converting enzyme 2 (ACE2) diabetes diabetic cardiomyopathy vascular complication...
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Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin angiotensin-converting enzyme 2 diabetes diabetic cardiomyopathy renin–angiotensin system Paraffin serial sections 4-μm thick were prepared from 4% PFA (paraformaldehyde)-fixed paraffin-embedded mouse aorta...
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Clin Sci (Lond) (2010) 118 (3): 211–220.
Published: 01 February 2010
... (angiotensin-converting enzyme). In experimental models of hypertension, Ac-SDKP has antifibrotic effects in the heart; however, the role of Ac-SDKP in diabetic cardiomyopathy is currently unknown. The aim of the present study was to evaluate the effect of Ac-SDKP on cardiac systolic and diastolic function...
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Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
...Omar Asghar; Ahmed Al-Sunni; Kaivan Khavandi; Ali Khavandi; Sarah Withers; Adam Greenstein; Anthony M. Heagerty; Rayaz A. Malik Diabetic cardiomyopathy is a distinct primary disease process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Epidemiological...
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Clin Sci (Lond) (2004) 107 (6): 539–557.
Published: 24 November 2004
... with heart failure. This suggests that there is an urgent need to conduct pathogenetic, diagnostic and therapeutic studies specifically in diabetic patients with cardiomyopathy to better understand the factors which initiate and progress diabetic cardiomyopathy and to develop more effective treatments...