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Keywords: diabetic cardiomyopathy
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Articles
Clin Sci (Lond) (2020) 134 (6): 609–628.
Published: 24 March 2020
... development and has been implicated in cardiovascular diseases. In the present study, we investigated the effects of RXR agonist treatment on streptozotocin (STZ)-induced diabetic cardiomyopathy (DCM) and the underlying mechanism. Sprague–Dawley (SD) rats induced by STZ injection were treated with either RXR...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1877–1893.
Published: 07 July 2017
...Fan Wu; Baile Wang; Saisai Zhang; Lihua Shi; Yanfang Wang; Rongrong Xiong; Xuebo Pan; Fanghua Gong; Xiaokun Li; Zhuofeng Lin The aim of the present study is to explore the molecular mechanism of fibroblast growth factor 21 (FGF21) in protecting against diabetic cardiomyopathy (DCM). Streptozotocin...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1841–1857.
Published: 05 July 2017
...Zheng Xu; Qian Tong; Zhiguo Zhang; Shudong Wang; Yang Zheng; Qiuju Liu; Ling-bo Qian; Shao-yu Chen; Jian Sun; Lu Cai Inhibition of total histone deacetylases (HDACs) was phenomenally associated with the prevention of diabetic cardiomyopathy (DCM). However, which specific HDAC plays the key role...
Articles
Clin Sci (Lond) (2017) 131 (12): 1345–1360.
Published: 07 June 2017
... by delayed intervention with rAAV6-caPI3K. Hence, our demonstration that cardiac-targeted PI3K (p110α) gene therapy limits diabetes-induced up-regulation of NADPH oxidase and cardiac remodelling suggests new insights into promising approaches for the treatment of diabetic cardiomyopathy, at a clinically...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (10): 897–915.
Published: 04 May 2017
...Mitchel Tate; David J. Grieve; Rebecca H. Ritchie Diabetes increases the risk of heart failure approximately 2.5-fold, independent of coronary artery disease and other comorbidities. This process, termed diabetic cardiomyopathy, is characterized by initial impairment of left ventricular (LV...
Articles
Clin Sci (Lond) (2016) 130 (17): 1511–1521.
Published: 18 July 2016
...Tao Bai; Fan Wang; Yang Zheng; Qiangrong Liang; Yuehui Wang; Jian Kong; Lu Cai Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications in diabetes that increase the mortality of diabetic patients. Mechanisms underlying DCM have not been fully elucidated, hindering targeted...
Articles
Clin Sci (Lond) (2016) 130 (8): 625–641.
Published: 08 March 2016
... potentially repurposing to prevent the cardiac abnormalities in patients with type 1 diabetes. We demonstrated here that fenofibrate significantly prevented diabetes-induced cardiac dysfunction and remodeling in fibroblast growth factor 21 (FGF21)-dependent manner. autophagy diabetic cardiomyopathy...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (5): 321–323.
Published: 13 November 2014
... in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H 2 S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science , Zhou et al. demonstrate...
Articles
Clin Sci (Lond) (2015) 128 (5): 325–335.
Published: 13 November 2014
...Xiang Zhou; Guoyin An; Xiang Lu There is growing evidence that H 2 S has beneficial effects in treatment of various cardiovascular diseases. However, it remains unclear whether H 2 S can attenuate the development of diabetic cardiomyopathy (DCM). The present study was designed to investigate...
Articles
Clin Sci (Lond) (2014) 126 (7): 471–482.
Published: 06 December 2013
... 2013 12 9 2013 2 10 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin-(1–7) angiotensin-converting enzyme 2 (ACE2) diabetes diabetic cardiomyopathy vascular complication ACE2, a homologue of ACE, was discovered in 2000...
Articles
Clin Sci (Lond) (2013) 124 (8): 529–545.
Published: 08 January 2013
... (angiotensin receptor blockers) or ACEis (angiotensin-converting enzyme inhibitors). In the present study, we determined whether renin inhibition is more effective at preventing diabetic cardiomyopathy than an ARB or ACEi. Diabetes was induced in adult mice for 10 weeks by STZ (streptozotocin). Diabetic mice...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (8): 519–529.
Published: 03 July 2012
.... angiotensin angiotensin-converting enzyme 2 diabetes diabetic cardiomyopathy renin–angiotensin system Correspondence : Professor Merlin Thomas (email Merlin.Thomas@bakeridi.edu.au ). 19 12 2011 22 5 2012 23 5 2012 23 5 2012 © The Authors Journal compilation © 2012...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (4): 161–173.
Published: 14 October 2011
... facilitates the development of cardiac hypertrophy and fibrosis, which eventually leads to LV dysfunction [ 19 ], suggesting that PKCβ may play a central role in the development of diabetic cardiomyopathy. RBX (ruboxistaurin; LY333531), a selective PKCβ inhibitor, has been shown to effectively ameliorate...
Articles
Clin Sci (Lond) (2010) 118 (3): 211–220.
Published: 01 February 2010
... (angiotensin-converting enzyme). In experimental models of hypertension, Ac-SDKP has antifibrotic effects in the heart; however, the role of Ac-SDKP in diabetic cardiomyopathy is currently unknown. The aim of the present study was to evaluate the effect of Ac-SDKP on cardiac systolic and diastolic function...
Articles
Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
...Omar Asghar; Ahmed Al-Sunni; Kaivan Khavandi; Ali Khavandi; Sarah Withers; Adam Greenstein; Anthony M. Heagerty; Rayaz A. Malik Diabetic cardiomyopathy is a distinct primary disease process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Epidemiological...
Articles
Clin Sci (Lond) (2004) 107 (6): 539–557.
Published: 24 November 2004
... with heart failure. This suggests that there is an urgent need to conduct pathogenetic, diagnostic and therapeutic studies specifically in diabetic patients with cardiomyopathy to better understand the factors which initiate and progress diabetic cardiomyopathy and to develop more effective treatments...