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Keywords: diabetic nephropathy
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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... a transformative agreement with CAUL. diabetic nephropathy inflammation MCC950 NLRP3 inflammasome oxidative stress Diabetic kidney disease (DKD) develops in up to 40% of diabetic patients and remains the major cause of end-stage renal disease worldwide contributing to increased morbidity...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
Clin Sci (Lond) (2020) 134 (2): 239–259.
Published: 29 January 2020
... ) Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway . Diabetes 57 , 460 – 469 10.2337/db07-1119 17959934 23. Frezza C. , Cipolat S. and Scorrano L. ( 2007 ) Organelle...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... ( phillip.kantharidis@monash.edu ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes Historically, diabetes...
Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia. 14 08 2018 04 12 2018 07 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 chronic kidney disease diabetic nephropathy transforming...
Clin Sci (Lond) (2018) 132 (22): 2407–2422.
Published: 22 November 2018
... with abdominal visceral fat accumulation and adiponectin levels in obese patients [ 23 ]. However, the expression of ADRP and SREBP-1 in PBMCs of DKD patients remains unknown. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADRP diabetic nephropathy...
Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... enhances the incidence or severity of acute kidney injury (AKI). diabetic nephropathy glucose transport renal physiology Type 2 diabetes mellitus (T2DM) is a major public health concern [ 1 ]. The main feature of T2DM is chronic or periodic hyperglycemia which in turn can lead to progression...
Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
...Ming Zhan; Irtaza Usman; Jingbo Yu; Liemin Ruan; Xueyan Bian; Jun Yang; Shikun Yang; Lin Sun; Yashpal S. Kanwar Renal tubular injury is increasingly being recognized as an early characteristic of diabetic nephropathy (DN). Mitochondrial dynamic alterations and redox protein p66Shc-mediated...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... to determine IR, this review article will focus on imaging techniques that could be utilized to determine renal IR and that could be tested to predict kidney disease development and progression. Correspondence: Alessia Fornoni ( AFornoni@med.miami.edu ) diabetic nephropathy diagnostics functional...
Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...
Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
.... Ricardo (email sharon.ricardo@monash.edu) 27 7 2016 10 12 2016 3 1 2017 4 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis mesangial cells microRNA (miRNA) transforming...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...
Clin Sci (Lond) (2015) 129 (12): 1237–1249.
Published: 11 November 2015
...Aaron D. McClelland; Michal Herman-Edelstein; Radko Komers; Jay C. Jha; Catherine E. Winbanks; Shinji Hagiwara; Paul Gregorevic; Phillip Kantharidis; Mark E. Cooper The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
Clin Sci (Lond) (2014) 126 (10): 707–720.
Published: 27 January 2014
... at 8 weeks of age to hasten the development of diabetic nephropathy as described previously [ 10 ]. db / m mice that received a uninephrectomy at 8 weeks of age served as the operation control. albuminuria angiotensin II diabetic nephropathy inflammation NADPH oxidase (Nox) podocyte...
Clin Sci (Lond) (2013) 124 (11): 685–694.
Published: 15 February 2013
... for therapeutic management in a setting of chronic kidney disease. Correspondence: Dr Richard L. Hébert (email rlhebert@uottawa.ca ). 8 10 2012 8 1 2013 11 1 2013 11 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 celecoxib diabetic nephropathy...
Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...
Clin Sci (Lond) (2013) 124 (8): 543–552.
Published: 08 January 2013
... unrecognized events that may contribute to development of DN, but also could lead to establishment of new diagnostic markers that can be employed during the early stage of DM prior to development of albuminuria. diabetic nephropathy mitochondrial proteins nitric oxide 3-nitrotyrosine oxidative stress...
Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...
Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...
Clin Sci (Lond) (2009) 116 (6): 479–492.
Published: 12 February 2009
...Antonio Rivero; Carmen Mora; Mercedes Muros; Javier García; Havidian Herrera; Juan F. Navarro-González Diabetes and its complications have become a public health problem. One of the most important complications is diabetic nephropathy, which is nowadays the main cause of chronic renal failure...
Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...
Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...
Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...
Clin Sci (Lond) (2002) 102 (1): 69–75.
Published: 10 December 2001
... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...
Clin Sci (Lond) (2001) 100 (6): 591–599.
Published: 25 April 2001
...Zemin CAO; Fabrice BONNET; Belinda DAVIS; Terri J. ALLEN; Mark E. COOPER Angiotensin II plays a pivotal role in the development of diabetic nephropathy, but it remains controversial as to the best approach to effectively block the actions of this hormone in the kidney. The aim of the present study...
Clin Sci (Lond) (1998) 94 (5): 511–516.
Published: 01 May 1998
... accumulation. This difference does not result from differences in glomerular-converting enzyme activity. 13 11 1997 12 12 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 angiostensin-converting enzyme inhibitors diabetic nephropathy glomerular angiotensin...
Clin Sci (Lond) (1998) 94 (2): 165–173.
Published: 01 February 1998
...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...
Clin Sci (Lond) (1995) 88 (4): 421–426.
Published: 01 April 1995
... resistance arterioles or the efferent glomerular arterioles, this could lead to systemic and intraglomerular hypertension, factors which may contribute to the development of diabetic nephropathy. 1 12 1994 15 12 1994 © 1995 The Biochemical Society and the Medical Research Society 1995...
Clin Sci (Lond) (1992) 82 (1): 19–23.
Published: 01 January 1992
... atenolol diabetic nephropathy enalapril non-insulin-dependent diabetes proteinuria tissue angiotensin Clinical Science (I 992) 82, 19-23 (Printed in Great Britain) Persistent albuminuria in normotensive non-insulin- dependent (type II) diabetic patients: comparative effects of angiotensin...
Clin Sci (Lond) (1989) 77 (5): 521–527.
Published: 01 November 1989
... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...
Clin Sci (Lond) (1986) 71 (2): 217–220.
Published: 01 August 1986
... and angiotensin II were similar in both groups. 4. The reduced density of angiotensin II receptors on platelets from patients with insulin-dependent diabetes may reflect a generalized abnormality of angiotensin II receptor regulation. angiotensin II diabetes mellitus diabetic nephropathy platelets...