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Keywords: diabetic nephropathy
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Clin Sci (Lond) (2024) 138 (16): 991–1007.
Published: 14 August 2024
... with CAUL. Cellular Senescence diabetic nephropathy inlfammation renal fibrosis National Health and Medical Research Council (NHMRC) 501100000925 APP2011355 Cellular senescence is a physiological and natural process in organic systems. The word ‘senescence’ originates from...
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Clin Sci (Lond) (2022) 136 (7): 493–520.
Published: 13 April 2022
...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... ameliorated urinary albumin excretion and mesangial expansion compared with wildtype diabetic animals [ 5 ]. diabetic nephropathy inflammation MCC950 NLRP3 inflammasome oxidative stress © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (18): 2469–2487.
Published: 25 September 2020
...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...
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Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... ( [email protected] ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes The development...
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Clin Sci (Lond) (2019) 133 (2): 287–313.
Published: 25 January 2019
... of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia. 14 08 2018 04 12 2018 07 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 chronic kidney disease diabetic nephropathy...
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Clin Sci (Lond) (2018) 132 (22): 2407–2422.
Published: 22 November 2018
... be associated with the tubular injury that occurs during DKD. Figure 2 Ectopic lipid accumulation and increased ADRP, SREBP-1 expression in the kidney tubule of DKD patients ( A ) The histological changes in renal biopsies of type 2 diabetic nephropathy patients were assessed by HE ( a–d ), PAS ( e–h...
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Clin Sci (Lond) (2018) 132 (12): 1329–1339.
Published: 28 June 2018
... with placebo over 66 months on renal and CV outcomes in 4401 participants with T2DM and diabetic nephropathy (CREDENCE). The latter study will provide more insights into the effects of SGLT2 inhibition on the progression of renal impairment in patients with established diabetic kidney disease compared...
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Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... to determine IR, this review article will focus on imaging techniques that could be utilized to determine renal IR and that could be tested to predict kidney disease development and progression. Correspondence: Alessia Fornoni ( [email protected] ) diabetic nephropathy diagnostics functional...
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Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...
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Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
... of the MAPK1 pathway. These studies demonstrate the protective function of MAPK1, regulated by miR-378 , in the induction of kidney cell fibrosis and mesangial hypertrophy. • Diabetic nephropathy (DN) is the leading cause of chronic kidney failure in patients with diabetes. It is characterized...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (9): 711–720.
Published: 18 March 2016
...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...
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Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...
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Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
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Clin Sci (Lond) (2013) 124 (9): 553–566.
Published: 21 January 2013
...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...
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Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... [email protected] ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...
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Clin Sci (Lond) (2013) 124 (3): 153–164.
Published: 05 October 2012
..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...
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Clin Sci (Lond) (2013) 124 (3): 139–152.
Published: 02 October 2012
...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...
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Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
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Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...
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Clin Sci (Lond) (2008) 114 (2): 109–118.
Published: 11 December 2007
...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...
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Clin Sci (Lond) (2007) 113 (4): 183–193.
Published: 13 July 2007
... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...
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Clin Sci (Lond) (2002) 102 (1): 69–75.
Published: 10 December 2001
... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...
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Clin Sci (Lond) (1998) 94 (2): 165–173.
Published: 01 February 1998
...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...
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Clin Sci (Lond) (1989) 77 (5): 521–527.
Published: 01 November 1989
... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...
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Clin Sci (Lond) (1986) 71 (2): 217–220.
Published: 01 August 1986
... and the Medical Research Society 1986 angiotensin II diabetes mellitus diabetic nephropathy platelets, receptors ClinicalScience(l986) 71, 217-220 SHORT COMMUNICATION 217 Reduced number of angiotensin I1 receptors on platelets in insulin-dependent diabetes J. M. C. CONNELL, YU-AN DING*, B. M. FISHER...