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DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Ming Yang, Qin Zhang, Shilu Luo, Yachun Han, Hao Zhao, Na Jiang, Yan Liu, Li Li, Chenrui Li, Chongbin Liu, Liyu He, Xuejing Zhu, Yu Liu, Lin Sun

Clin Sci (Lond) (2023) 137 (12): 931–945.

https://doi.org/10.1042/CS20220787

Published: 20 June 2023

... of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprotection, but whether it activates mitophagy by maintaining MAM integrity remains unclear. In the present study, we found that renal tubular damage was further aggravated in diabetic DsbA-L −/− mice compared with diabetic...

View article titled, DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

Includes: Supplementary data

Articles

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler

Clin Sci (Lond) (2023) 137 (1): 87–104.

https://doi.org/10.1042/CS20220447

Published: 05 January 2023

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 Diabetic nephropathy Empagliflozin NHE3 Proteomics RAS blockade SGLT2i Diabetic nephropathy (DN) is a renal microvascular complication of diabetes mellitus (DM). Currently, 537 million people...

View article titled, The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy

Includes: Supplementary data

Articles

Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

William P. Martin, Meera Nair, Yeong H.D. Chuah, Daniel Malmodin, Anders Pedersen, Sanna Abrahamsson, Michaela Hutter, Mahmoud Abdelaal, Jessie A. Elliott, Naomi Fearon, Hans Eckhardt, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty

Clin Sci (Lond) (2022) 136 (21): 1485–1511.

https://doi.org/10.1042/CS20220205

Published: 03 November 2022

... experimental group. Correspondence: Neil G. Docherty ( neil.docherty@ucd.ie ) 01 04 2022 14 10 2022 18 10 2022 19 10 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 diabetic nephropathy fatty acid oxidation...

View article titled, Dietary restriction and medical therapy drives PPARα-regulated improvements in early diabetic kidney disease in male rats

Includes: Supplementary data

Articles

Mechanisms of podocyte injury and implications for diabetic nephropathy

Federica Barutta, Stefania Bellini, Gabriella Gruden

Clin Sci (Lond) (2022) 136 (7): 493–520.

https://doi.org/10.1042/CS20210625

Published: 13 April 2022

...Federica Barutta; Stefania Bellini; Gabriella Gruden Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature...

View article titled, Mechanisms of podocyte injury and implications for diabetic nephropathy

Articles

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm

Clin Sci (Lond) (2022) 136 (2): 167–180.

https://doi.org/10.1042/CS20210865

Published: 20 January 2022

... diabetic animals [ 5 ]. diabetic nephropathy inflammation MCC950 NLRP3 inflammasome oxidative stress © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution...

View article titled, Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Includes: Supplementary data

Articles

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu

Clin Sci (Lond) (2020) 134 (23): 3175–3193.

https://doi.org/10.1042/CS20201207

Published: 09 December 2020

...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...

View article titled, Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis

Includes: Supplementary data

Articles

Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Zhuo Li, Hua Guo, Jia Li, Tianjiao Ma, Shanshan Zhou, Zhiguo Zhang, Lining Miao, Lu Cai

Clin Sci (Lond) (2020) 134 (18): 2469–2487.

https://doi.org/10.1042/CS20191088

Published: 25 September 2020

...Zhuo Li; Hua Guo; Jia Li; Tianjiao Ma; Shanshan Zhou; Zhiguo Zhang; Lining Miao; Lu Cai Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2). AMP-activated protein kinase (AMPK) can attenuate...

View article titled, Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function

Includes: Supplementary data

Articles

The role of protein arginine methyltransferases in kidney diseases

Chunyun Zhang, Shougang Zhuang

Clin Sci (Lond) (2020) 134 (15): 2037–2051.

https://doi.org/10.1042/CS20200680

Published: 07 August 2020

... products—symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)—are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate...

View article titled, The role of protein arginine methyltransferases in kidney diseases

Articles

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Runa S.J. Lindblom, Gavin C. Higgins, Tuong-Vi Nguyen, Maryann Arnstein, Darren C. Henstridge, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Mark E. Cooper, Josephine M. Forbes, Melinda T. Coughlan

Clin Sci (Lond) (2020) 134 (2): 239–259.

https://doi.org/10.1042/CS20190787

Published: 29 January 2020

... ratio RER respiratory exchange ratio ROS reactive oxygen species RT-qPCR quantitative reverse transcription-polymerase chain reaction STZ streptozotocin V. vehicle control treated (10% Cremophor EL) WT wild type cell death cyclophilin D diabetic nephropathy...

View article titled, Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Includes: Supplementary data

Articles

Specialized pro-resolving mediators in diabetes: novel therapeutic strategies

Eoin P. Brennan, Muthukumar Mohan, Darrell Andrews, Madhura Bose, Phillip Kantharidis

Clin Sci (Lond) (2019) 133 (21): 2121–2141.

https://doi.org/10.1042/CS20190067

Published: 06 November 2019

... cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes References 1. Keck F.S. and Pfeiffer E.F. ( 1989 ) The first experimental diabetes mellitus . Acta Diabetol. Lat. 26 , 79 – 81 10.1007/BF02581200 2665408 2. Banting F.G...

View article titled, Specialized pro-resolving mediators in diabetes: novel therapeutic strategies

Articles

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

Pacific Huynh, Zhonglin Chai

Clin Sci (Lond) (2019) 133 (2): 287–313.

https://doi.org/10.1042/CS20180438

Published: 25 January 2019

... TGFβ Neutralizing antibody • Attenuation of renal fibrosis in rodent models of Type 1 [ 194 , 205 ] and Type 2 diabetic nephropathy [ 195 , 206 ], obstructive nephropathy [ 176 , 197 , 198 ] and ischaemia/reperfusion injury [ 207 ] Genetic knockout • Macrophage-specific TGFβ-knockout did...

View article titled, Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

Articles

Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease

Wenxia Yang, Ying Luo, Shikun Yang, Mengru Zeng, Shumin Zhang, Jialu Liu, Yuzhang Han, Yu Liu, Xuejing Zhu, Hao Wu, Fuyou Liu, Lin Sun, Li Xiao

Clin Sci (Lond) (2018) 132 (22): 2407–2422.

https://doi.org/10.1042/CS20180702

Published: 22 November 2018

... accumulation and adiponectin levels in obese patients [ 23 ]. However, the expression of ADRP and SREBP-1 in PBMCs of DKD patients remains unknown. ADRP diabetic nephropathy ectopic lipid accumulation sterol regulatory element-binding proteins tubular injury Diabetic kidney disease (DKD...

View article titled, Ectopic lipid accumulation: potential role in tubular injury and inflammation in diabetic kidney disease

Articles

SGLT2 inhibition and kidney protection

Josselin Nespoux, Volker Vallon

Clin Sci (Lond) (2018) 132 (12): 1329–1339.

https://doi.org/10.1042/CS20171298

Published: 28 June 2018

... enhances the incidence or severity of acute kidney injury (AKI). diabetic nephropathy glucose transport renal physiology Type 2 diabetes mellitus (T2DM) is a major public health concern [ 1 ]. The main feature of T2DM is chronic or periodic hyperglycemia which in turn can lead to progression...

View article titled, SGLT2 inhibition and kidney protection

Articles

Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Ming Zhan, Irtaza Usman, Jingbo Yu, Liemin Ruan, Xueyan Bian, Jun Yang, Shikun Yang, Lin Sun, Yashpal S. Kanwar

Clin Sci (Lond) (2018) 132 (12): 1297–1314.

https://doi.org/10.1042/CS20180005

Published: 26 June 2018

...Ming Zhan; Irtaza Usman; Jingbo Yu; Liemin Ruan; Xueyan Bian; Jun Yang; Shikun Yang; Lin Sun; Yashpal S. Kanwar Renal tubular injury is increasingly being recognized as an early characteristic of diabetic nephropathy (DN). Mitochondrial dynamic alterations and redox protein p66Shc-mediated...

View article titled, Perturbations in mitochondrial dynamics by p66Shc lead to renal tubular oxidative injury in human diabetic nephropathy

Includes: Supplementary data

Articles

Probing insulin sensitivity in diabetic kidney disease: is there a stronger role for functional imaging?

Michael L. Granda, Pooja Amarapurkar, Alessia Fornoni

Clin Sci (Lond) (2018) 132 (11): 1085–1095.

https://doi.org/10.1042/CS20171490

Published: 05 June 2018

... receptor remains unclear, however PTP1B and TCPTP exhibit differential effects on IS and may both serve as therapeutic targets [ 50 ]. Rat podocytes display decreased Akt activation and IS early in the course of diabetic nephropathy, even before measurable MA. These same diabetic podocytes appeared...

View article titled, Probing insulin sensitivity in diabetic kidney disease: is there a stronger role for functional imaging?

Articles

Diabetic nephropathy – is this an immune disorder?

Greg H. Tesch

Clin Sci (Lond) (2017) 131 (16): 2183–2199.

https://doi.org/10.1042/CS20160636

Published: 31 July 2017

... 30–40% of patients with diabetes develop nephropathy and this renal injury normally progresses in about a third of patients. Due to the growing incidence of diabetes, diabetic nephropathy is now the main cause of end-stage renal disease (ESRD) worldwide. Accumulating evidence from experimental...

View article titled, Diabetic nephropathy – is this an immune disorder?

Articles

miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling

Bo Wang, Kevin Yao, Andrea F. Wise, Ricky Lau, Hsin-Hui Shen, Greg H. Tesch, Sharon D. Ricardo

Clin Sci (Lond) (2017) 131 (5): 411–423.

https://doi.org/10.1042/CS20160571

Published: 17 February 2017

... 1 2017 © 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy kidney fibrosis mesangial cells microRNA (miRNA) transforming growth factor-β (TGF-β1) • Diabetic nephropathy (DN) is the leading cause...

View article titled, miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling

Includes: Supplementary data

Articles

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Melinda T. Coughlan, Tuong-Vi Nguyen, Sally A. Penfold, Gavin C. Higgins, Vicki Thallas-Bonke, Sih Min Tan, Nicole J. Van Bergen, Karly C. Sourris, Brooke E. Harcourt, David R. Thorburn, Ian A. Trounce, Mark E. Cooper, Josephine M. Forbes

Clin Sci (Lond) (2016) 130 (9): 711–720.

https://doi.org/10.1042/CS20150838

Published: 18 March 2016

...; published by Portland Press Limited 2016 We identified that dysfunction of cellular power stations, mitochondria, may precede the development of kidney disease in diabetes. This suggests that mitochondrial dysfunction is a primary cause of diabetic nephropathy, which could be targeted to improve...

View article titled, Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Articles

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Aaron D. McClelland, Michal Herman-Edelstein, Radko Komers, Jay C. Jha, Catherine E. Winbanks, Shinji Hagiwara, Paul Gregorevic, Phillip Kantharidis, Mark E. Cooper

Clin Sci (Lond) (2015) 129 (12): 1237–1249.

https://doi.org/10.1042/CS20150427

Published: 11 November 2015

...Aaron D. McClelland; Michal Herman-Edelstein; Radko Komers; Jay C. Jha; Catherine E. Winbanks; Shinji Hagiwara; Paul Gregorevic; Phillip Kantharidis; Mark E. Cooper The cytokine transforming growth factor (TGF)-β1 plays a central role in diabetic nephropathy (DN) with data implicating the miRNA...

View article titled, miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Includes: Supplementary data

Articles

Role of the potassium channel K Ca 3.1 in diabetic nephropathy

Chunling Huang, Carol A. Pollock, Xin-Ming Chen

Clin Sci (Lond) (2014) 127 (7): 423–433.

https://doi.org/10.1042/CS20140075

Published: 17 June 2014

...Chunling Huang; Carol A. Pollock; Xin-Ming Chen There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointerstitial fibrosis has been shown to be the final...

View article titled, Role of the potassium channel K Ca 3.1 in diabetic nephropathy

Articles

Role of Toll-like receptors in diabetic nephropathy

Harshini Mudaliar, Carol Pollock, Usha Panchapakesan

Clin Sci (Lond) (2014) 126 (10): 685–694.

https://doi.org/10.1042/CS20130267

Published: 27 January 2014

...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...

View article titled, Role of Toll-like receptors in diabetic nephropathy

Articles

Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation

Guangyu Zhou, Alfred K. Cheung, Xia Liu, Yufeng Huang

Clin Sci (Lond) (2014) 126 (10): 707–720.

https://doi.org/10.1042/CS20130223

Published: 27 January 2014

... long-term renoprotection. Activity of the RAS (renin–angiotensin system) is elevated both in the circulation and renal tissue of patients with diabetic nephropathy. Increased activity of the RAS plays an important role in the haemodynamic and non-haemodynamic pathogenetic mechanisms involved...

View article titled, Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation

Articles

Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental

Rania Nasrallah, Susan J. Robertson, Jacob Karsh, Richard L. Hébert

Clin Sci (Lond) (2013) 124 (11): 685–694.

https://doi.org/10.1042/CS20120543

Published: 15 February 2013

... for therapeutic management in a setting of chronic kidney disease. Correspondence: Dr Richard L. Hébert (email rlhebert@uottawa.ca ). 8 10 2012 8 1 2013 11 1 2013 11 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 celecoxib diabetic nephropathy...

View article titled, Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental

Articles

Renin inhibition in the treatment of diabetic kidney disease

Radko Komers

Clin Sci (Lond) (2013) 124 (9): 553–566.

https://doi.org/10.1042/CS20120468

Published: 21 January 2013

...Radko Komers Inhibition of the RAAS (renin–angiotensin–aldosterone system) plays a pivotal role in the prevention and treatment of diabetic nephropathy and a spectrum of other proteinuric kidney diseases. Despite documented beneficial effects of RAAS inhibitors in diabetic patients with nephropathy...

View article titled, Renin inhibition in the treatment of diabetic kidney disease

Articles

Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats

Naohito Ishii, Pamela K. Carmines, Masanori Yokoba, Hiroyuki Imaizumi, Tsuyoshi Ichikawa, Hideki Ikenagasa, Yoshio Kodera, Masamichi Oh-Ishi, Yoshikazu Aoki, Tadakazu Maeda, Tsuneo Takenaka, Masato Katagiri

Clin Sci (Lond) (2013) 124 (8): 543–552.

https://doi.org/10.1042/CS20120251

Published: 08 January 2013

... stages of DN (diabetic nephropathy) [ 1 ]. In Japan, normal albumin values for morning urine samples and spot (random) urine samples are less than 16.5 mg/l (10.8 mg of creatinine/g) and 29.3 mg/l (24.6 mg of creatinine/g) respectively [ 2 ], values that differ by approximately 2-fold. Indeed...

View article titled, Angiotensin-converting enzyme inhibition curbs tyrosine nitration of mitochondrial proteins in the renal cortex during the early stage of diabetes mellitus in rats

Articles

Insulin signalling to the kidney in health and disease

Lorna J. Hale, Richard J. M. Coward

Clin Sci (Lond) (2013) 124 (6): 351–370.

https://doi.org/10.1042/CS20120378

Published: 27 November 2012

... Richard.Coward@bristol.ac.uk ). 13 7 2012 14 9 2012 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 diabetes diabetic nephropathy insulin intracellular signalling kidney metabolic syndrome The role of insulin in the human body has been...

View article titled, Insulin signalling to the kidney in health and disease

Articles

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Munehiro Kitada, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, Daisuke Koya

Clin Sci (Lond) (2013) 124 (3): 153–164.

https://doi.org/10.1042/CS20120190

Published: 05 October 2012

..., inflammation and fibrosis, and may regulate lipid metabolism, autophagy, blood pressure and sodium balance. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy...

View article titled, Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

Articles

Inflammation and the pathogenesis of diabetic nephropathy

Jun Wada, Hirofumi Makino

Clin Sci (Lond) (2013) 124 (3): 139–152.

https://doi.org/10.1042/CS20120198

Published: 02 October 2012

...Jun Wada; Hirofumi Makino The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous...

View article titled, Inflammation and the pathogenesis of diabetic nephropathy

Articles

Pathogenic perspectives for the role of inflammation in diabetic nephropathy

Antonio Rivero, Carmen Mora, Mercedes Muros, Javier García, Havidian Herrera, Juan F. Navarro-González

Clin Sci (Lond) (2009) 116 (6): 479–492.

https://doi.org/10.1042/CS20080394

Published: 12 February 2009

...Antonio Rivero; Carmen Mora; Mercedes Muros; Javier García; Havidian Herrera; Juan F. Navarro-González Diabetes and its complications have become a public health problem. One of the most important complications is diabetic nephropathy, which is nowadays the main cause of chronic renal failure...

View article titled, Pathogenic perspectives for the role of inflammation in diabetic nephropathy

Articles

Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes

Monika Buraczynska, Andrzej Swatowski, Kinga Buraczynska, Michal Dragan, Andrzej Ksiazek

Clin Sci (Lond) (2009) 116 (1): 81–86.

https://doi.org/10.1042/CS20070411

Published: 28 November 2008

..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...

View article titled, Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes

Articles

Role of PPARγ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential

Jichun Yang, Dongjuan Zhang, Jing Li, Xiaoyan Zhang, Fenling Fan, Youfei Guan

Clin Sci (Lond) (2009) 116 (1): 17–26.

https://doi.org/10.1042/CS20070462

Published: 28 November 2008

...Jichun Yang; Dongjuan Zhang; Jing Li; Xiaoyan Zhang; Fenling Fan; Youfei Guan DN (diabetic nephropathy) is a chronic disease characterized by proteinuria, glomerular hypertrophy, decreased glomerular filtration and renal fibrosis with loss of renal function. DN is the leading cause of ESRD (end...

View article titled, Role of PPARγ in renoprotection in Type 2 diabetes: molecular mechanisms and therapeutic potential

Articles

Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

David Z. Levine

Clin Sci (Lond) (2008) 114 (2): 109–118.

https://doi.org/10.1042/CS20070088

Published: 11 December 2007

...David Z. Levine In the past, hyperfiltration and increased glomerular capillary pressure have been identified as important determinants of the development of DN (diabetic nephropathy). Recently, some basic research and clinical reviews on DN have omitted identifying hyperfiltration as an important...

View article titled, Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties

Articles

Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise

Xiao C. Li, Jia L. Zhuo

Clin Sci (Lond) (2007) 113 (4): 183–193.

https://doi.org/10.1042/CS20070040

Published: 13 July 2007

... glucose tolerance and the development of glomerular hyperfiltration and microalbuminuria, ultimately leading to diabetic nephropathy and end-stage renal disease. Clinical studies have suggested that an inappropriate increase in hyperglycaemic glucagon (hyperglucagonaemia) over hypoglycaemic insulin...

View article titled, Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise

Articles

Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy

Nicholas J.M. FARDON, Robert WILKINSON, Trevor H. THOMAS

Clin Sci (Lond) (2002) 102 (1): 69–75.

https://doi.org/10.1042/cs1020069

Published: 10 December 2001

... contribute to the increased incidence of cardiovascular disease, was investigated. PMA-stimulated expression of CD11b and CD69 on neutrophils from normal controls (NC), long-term uncomplicated Type I diabetic control patients (DC) and diabetic nephropathy patients (DN) was determined by fluorescence...

View article titled, Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy

Articles

Additive hypotensive and anti-albuminuric effects of angiotensin-converting enzyme inhibition and angiotensin receptor antagonism in diabetic spontaneously hypertensive rats

Zemin CAO, Fabrice BONNET, Belinda DAVIS, Terri J. ALLEN, Mark E. COOPER

Clin Sci (Lond) (2001) 100 (6): 591–599.

https://doi.org/10.1042/cs1000591

Published: 25 April 2001

...Zemin CAO; Fabrice BONNET; Belinda DAVIS; Terri J. ALLEN; Mark E. COOPER Angiotensin II plays a pivotal role in the development of diabetic nephropathy, but it remains controversial as to the best approach to effectively block the actions of this hormone in the kidney. The aim of the present study...

View article titled, Additive hypotensive and anti-albuminuric effects of angiotensin-converting enzyme inhibition and angiotensin receptor antagonism in diabetic spontaneously hypertensive rats

Articles

Renoprotective Differences between Perindopril and Enalapril in the Diabetic Hypertensive Rat Do Not Reflect Glomerular Angiotensin-Converting Enzyme Activity

K. A. Duggan, G. Hodge, M. M. Makarious, J. A. Charlesworth

Clin Sci (Lond) (1998) 94 (5): 511–516.

https://doi.org/10.1042/cs0940511

Published: 01 May 1998

... accumulation. This difference does not result from differences in glomerular-converting enzyme activity. 13 11 1997 12 12 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 angiostensin-converting enzyme inhibitors diabetic nephropathy glomerular angiotensin...

View article titled, Renoprotective Differences between Perindopril and Enalapril in the Diabetic Hypertensive Rat Do Not Reflect Glomerular Angiotensin-Converting Enzyme Activity

Articles

Angiotensin-Converting Enzyme Inhibition Does Not Correct Early Defects in Renal and Vascular Permeability in Diabetes Mellitus

Robert Zietse, Frans H. Derkx, Willem Weimar, Maarten A. Schalekamp

Clin Sci (Lond) (1998) 94 (2): 165–173.

https://doi.org/10.1042/cs0940165

Published: 01 February 1998

...Robert Zietse; Frans H. Derkx; Willem Weimar; Maarten A. Schalekamp 1. In diabetes mellitus a selective increase in the excretion of albumin generally precedes the occurrence of demonstrable loss of glomerular size-selectivity. However, even in this (microalbuminuric) phase of diabetic nephropathy...

View article titled, Angiotensin-Converting Enzyme Inhibition Does Not Correct Early Defects in Renal and Vascular Permeability in Diabetes Mellitus

Articles

Selective Enhancement of α 2 -Adrenoceptor-Mediated Vasoconstriction in Insulin-Dependent Diabetic Patients with Microalbuminuria

Charles W. Bodmer, Nicolaas C. Schaper, Maureen Janssen, Peter W. De Leeuw, Gareth Williams

Clin Sci (Lond) (1995) 88 (4): 421–426.

https://doi.org/10.1042/cs0880421

Published: 01 April 1995

... resistance arterioles or the efferent glomerular arterioles, this could lead to systemic and intraglomerular hypertension, factors which may contribute to the development of diabetic nephropathy. 1 12 1994 15 12 1994 © 1995 The Biochemical Society and the Medical Research Society 1995...

View article titled, Selective Enhancement of α 2 -Adrenoceptor-Mediated Vasoconstriction in Insulin-Dependent Diabetic Patients with Microalbuminuria

Articles

Persistent albuminuria in normotensive non-insulin-dependent (type II) diabetic patients: comparative effects of angiotensin-converting enzyme inhibitors and β -adrenoceptor blockers

Michele Stornello, Enrico V. Valvo, Luigi Scapellato

Clin Sci (Lond) (1992) 82 (1): 19–23.

https://doi.org/10.1042/cs0820019

Published: 01 January 1992

...% of all insulin-dependent and non-insulin-dependent diabetic patients suffer from diabetic nephropathy, which is a clinical syndrome characterized by persistent albumin- uria, a progressive decline in glomerular filtration rate (GFR) and high blood pressure [ 1,3]. Both a reduction in protein intake...

View article titled, Persistent albuminuria in normotensive non-insulin-dependent (type II) diabetic patients: comparative effects of angiotensin-converting enzyme inhibitors and β -adrenoceptor blockers

Articles

Genetic Factors in the Development of Nephropathy in Diabetic Lewis and Da Rats

Colin D. Payton, J. M. Boulton-Jones

Clin Sci (Lond) (1989) 77 (5): 521–527.

https://doi.org/10.1042/cs0770521

Published: 01 November 1989

... months of diabetes. The median fractional mesangial area was 44.8% in the diabetic Lewis rats and 31.4% in the diabetic DA rats. 6. These results suggest that Lewis rats possess an inherited susceptibility to diabetic nephropathy, and that DA rats are relatively resistant. These differences...

View article titled, Genetic Factors in the Development of Nephropathy in Diabetic Lewis and Da Rats

Articles

Reduced number of angiotensin II receptors on platelets in insulin-dependent diabetes

J. M. C. Connell, Yu-An Ding, B. M. Fisher, B. M. Frier, P. F. Semple

Clin Sci (Lond) (1986) 71 (2): 217–220.

https://doi.org/10.1042/cs0710217

Published: 01 August 1986

... and the Medical Research Society 1986 angiotensin II diabetes mellitus diabetic nephropathy platelets, receptors ClinicalScience(l986) 71, 217-220 SHORT COMMUNICATION 217 Reduced number of angiotensin I1 receptors on platelets in insulin-dependent diabetes J. M. C. CONNELL, YU-AN DING*, B. M. FISHER...

View article titled, Reduced number of angiotensin II receptors on platelets in insulin-dependent diabetes

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