...) in response to intra-arterially administered diazoxide, acetylcholine and dipyridamole and to forearm ischaemia was measured. The diazoxide-mediated increase in the forearm blood flow ratio (infused/control arm) was significantly less pronounced after glibenclamide than after acarbose (290±58% and 561±101...

... patients with EHT and in 11 patients with RVHT measurements were made before and 25–35 min after an intravenous injection of 300 mg of diazoxide. 2. Under basal conditions the renal vein to artery ratios for active and inactive renin in EHT ranged from 0·71 to 1·96 and from 0·68 to 1·44 respectively. In 14...

...A. J. Man in 't Veld; G. J. Wenting; R. P. Verhoeven; M. A. D. H. Schalekamp 1. Haemodynamic responses to diazoxide (300 mg intravenously) were studied in 15 hypertensive patients before and after chronic β-adrenoreceptor blockade by 320 mg of propranolol daily. After diazoxide alone, mean arterial...

...R. Vandongen; Dianne M. Greenwood 1. The effect of diazoxide (17·3 μmol min —1 g —1 ) and frusemide (0·12 μmol min —1 g —1 ) on renin secretion was examined in the isolated perfused rat kidney. These substances are potential renal vasodilators with opposite effects on urine sodium excretion. 2...

...L. G. Fine; H. Weber 1. To assess whether diazoxide-induced sodium retention is due to a direct renal action of the drug, independent of its systemic haemodynamic effects, diazoxide was infused directly into one renal artery of hydropenic rats. During the infusion period there was a small fall...

...H. Thurston; J. E. F. Pohl; J. D. Swales 1. Oral diazoxide was administered to a group of ninety-seven patients with renal failure and severe hypertension which had proved resistant to conventional drug treatment. 2. Hypertension was satisfactorily controlled in every case, and resistance...

... failure unless the blood pressure is controlled. 2. Thiazides potentiate the effect of other hypotensive agents and this potentiation is probably independent of their diuretic action. Diazoxide actually produces salt and water retention at the same time as marked decrease in the blood pressure. Spirono...

...J. E. F. Pohl; H. Thurston; J. D. Swales 1. The renal response to a single slow intravenous injection of diazoxide has been studied in three patients with vasopressin-deficient diabetes insipidus, one patient with nephrogenic diabetes insipidus and three normal subjects. 2. In all patients...