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Articles
Clin Sci (Lond) (2016) 130 (15): 1285-1305.
Published: 29 June 2016
... cardiovascular disease diet epigenetic modification histones chromatin mitochondrial fusion–fission mitophagy Aerobic metabolism constitutes the energetic foundation of the great majority of living systems on Earth. By processing oxygen to harness the essential redox and phosphorylation energy...
Articles
Clin Sci (Lond) (2013) 124 (4): 231-241.
Published: 31 October 2012
... influence appetite and energy expenditure. Diet-induced weight loss is accompanied by several physiological changes which encourage weight regain, including alterations in energy expenditure, substrate metabolism and hormone pathways involved in appetite regulation, many of which persist beyond the initial...
Articles
Clin Sci (Lond) (2006) 111 (1): 71-80.
Published: 14 June 2006
...H. M. Omar Farouque; Michael Leung; Sarah A. Hope; Mauro Baldi; Clyde Schechter; James D. Cameron; Ian T. Meredith Evidence suggests that flavonoid-containing diets reduce cardiovascular risk, but the mechanisms responsible are unclear. In the present study, we sought to determine the effect of...
Articles
Clin Sci (Lond) (2006) 110 (6): 665-671.
Published: 15 May 2006
... metabolic syndrome and examine how that influences size of myocardial infarcts induced by occlusion and reperfusion of the left anterior descending coronary artery. Sprague–Dawley rats ( n =105) were fed either LF (low-fat) or MHF (moderately high-fat) diets for 13 weeks before coronary occlusion for 45 min...
Articles
Clin Sci (Lond) (2005) 108 (6): 553-559.
Published: 24 May 2005
... The Biochemical Society 2005 cholesterol diet homoeostatic model assessment (HOMA) insulin resistance lipoprotein metabolic syndrome risk factor The metabolic syndrome, also called insulin-resistance syndrome or syndrome X, is a cluster of cardiovascular disease risk factors [ 1...
Articles
Clin Sci (Lond) (2004) 106 (5): 447-448.
Published: 01 May 2004
...-inspired diet on endothelial function and lipid fractions. Correspondence: Dr Aroon Hingorani (e-mail a.hingorani@ucl.ac.uk ). 21 1 2004 26 1 2004 26 1 2004 © 2004 The Biochemical Society 2004 diet cardiovascular disease endothelial function lipid fraction oxidative...
Articles
Clin Sci (Lond) (2004) 106 (5): 519-525.
Published: 01 May 2004
...Anneli AMBRING; Peter FRIBERG; Mette AXELSEN; Magdalena LAFFRENZEN; Marja-Riitta TASKINEN; Samar BASU; Mats JOHANSSON Mediterranean-inspired diets have been shown to decrease cholesterol levels in patients with hypercholesterolaemia, who frequently exhibit endothelial dysfunction. The aims of the...
Articles
Clin Sci (Lond) (2004) 106 (2): 141-145.
Published: 01 February 2004
...), (b) recuperated (offspring of dams fed a low-protein diet during pregnancy, but nursed by control dams) and (c) postnatal low-protein (offspring of control dams nursed by low-protein-fed dams). Mice were weaned on to standard laboratory chow or a cafeteria diet. Recuperated offspring, although...
Articles
Clin Sci (Lond) (2003) 105 (4): 403-408.
Published: 01 October 2003
... levels and mRNA expression of adiponectin is due to obesity or to the diet itself. Wistar rats were either fed standard laboratory chow throughout (controls) or given a fat-enriched, glucose-enriched diet (diet-fed) for 2 days or 16 weeks. After 2 days of diet feeding, total body weight, fat pad masses...
Articles
Clin Sci (Lond) (2003) 105 (1): 13-20.
Published: 01 July 2003
... adhesion molecules atherosclerosis diet endothelial dysfunction fish oil non-esterified fatty acids Clinical Science (2003) 105, 13 20 (Printed in Great Britain) 13 Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified...
Articles
Clin Sci (Lond) (2003) 105 (1): 81-87.
Published: 01 July 2003
...Peter STEER; Dennis M. SARABI; Brita KARLSTRÖM; Samar BASU; Christian BERNE; Bengt VESSBY; Lars LIND Correspondence: Dr Peter Steer (e-mail Peter.Steer@medsci.uu.se ). 15 11 2002 3 2 2003 10 3 2003 10 3 2003 © 2003 The Biochemical Society 2003 diet...
Articles
Clin Sci (Lond) (2001) 100 (6): 635-641.
Published: 03 May 2001
... Syndrome X by voluntary feeding of Wistar rats with a highly palatable cafeteria diet, and examined its effects on metabolic changes and vascular reactivity of Wistar rats. At the end of the experiment, the cafeteria-diet fed group was divided into two groups of low weight gain (LWG) and high weight gain...
Articles
Clin Sci (Lond) (1998) 95 (4): 479-487.
Published: 01 October 1998
...Cliona NÍ MHURCHÚ; Barrie M. MARGETTS; Viv SPELLER 1. Intervention trials in free-living populations have shown relatively small reductions in risk factors for cardiovascular disease, including lipid levels, and have led some to question whether diet is an effective treatment for hyperlipidaemia...
Articles
Clin Sci (Lond) (1997) 93 (3): 257-263.
Published: 01 September 1997
... species of oxalate. 3. We studied 34 stone-forming patients on both a free-choice diet, whose Ca and oxalate content (24 and 1.2 mmol respectively) was assessed by dietary inquiry, and after 30 days on a prescribed low-calcium and normal oxalate diet (11 and 1.1 mmol respectively). Under both conditions...
Articles
Clin Sci (Lond) (1995) 89 (4): 447-452.
Published: 01 October 1995
... carbohydrates. 2. We have attempted to determine if the onset of myofibre necrosis in mdx mice at the time of weaning is related to the development of motor activity and/or the change in diet. 3. Fourteen-day-old mdx mice were divided into two groups after weaning. One group was trained to run on a treadmill...
Articles
Clin Sci (Lond) (1995) 89 (3): 305-310.
Published: 01 September 1995
... plasma sodium that usually occurs during dietary salt restriction, we water restricted (200 ml/day) six normal subjects for the 2 days after the transition from 260 (high-sodium diet, day 3) to 20 mmol (low-sodium diet, days 4 and 5) sodium per day. In the control (hydrated) group water intake was held...
Articles
Clin Sci (Lond) (1995) 89 (1): 37-43.
Published: 01 July 1995
... sensitivity to the hydro-osmotic and vascular effects of arginine vasopressin is enhanced by salt restriction. 27 3 1995 5 4 1995 © 1995 The Biochemical Society and the Medical Research Society 1995 arginine vasopressin diet low sodium kidney Clinical Science (1995) 89, 3743...
Articles
Clin Sci (Lond) (1993) 85 (5): 599-606.
Published: 01 November 1993
... 1993 desamino-[8-D-arginine]vasopressin diabetes insipidus diet low sodium Clinical Science (1993) 85, 5- (Printed in Grat Britain) 599 Control of sodium excretion in patients with cranial diabetes insipidus maintained on desamine m r g i n i n e jvaso pressin M. SUllERS, C. BRACE, E...
Articles
Clin Sci (Lond) (1993) 85 (4): 465-470.
Published: 01 October 1993
... © 1993 The Biochemical Society and the Medical Research Society 1993 arginine vasopressin diet diuresis salt restriction Clinical Science (1993) 85, 465-470 (Printed in Great Britain) 465 Effect of chronic lowdose arginine vasopressin infusion on body fluid homoeostasis during adaptation from...
Articles
Clin Sci (Lond) (1992) 83 (1): 97-101.
Published: 01 July 1992
... (9,12-octadecadienoic acid), namely 9,11-octadecadienoic acid. Diet may be another source of this isomer, raising questions as to its value as a free-radical marker. The aim of this study was to determine the importance of diet as a source of 9,11-octadecadienoic acid in phospholipid esterified fatty...
Articles
Clin Sci (Lond) (1992) 83 (1): 109-116.
Published: 01 July 1992
... have now measured basal metabolic rate and diet-induced thermogenesis in six patients with chronic obstructive pulmonary disease with an arterial partial pressure of CO 2 of <5kPa (emphysematous), nine patients with chronic obstructive pulmonary disease with an arterial partial pressure of CO 2 of...
Articles
Clin Sci (Lond) (1992) 82 (4): 433-438.
Published: 01 April 1992
...M. A. Manso; H. A. Gallego; I. de Dios 1. The effects of a diet rich in protein and fat, compared with a control diet, with or without chronic ingestion of ethanol on the pancreatic response to cholecystokinin were studied in rats after a 7-month treatment period. The acute effects of intraduodenal...
Articles
Clin Sci (Lond) (1990) 78 (6): 605-612.
Published: 01 June 1990
... high to a low sodium diet [2.70 (2.38–8.69) to 2.19 (1.72–4.00) and 3.80 (2.92–5.01) to 2.50 (1.26–2.35) pmol/h, respectively, P <0.05]; in four subjects assayed, plasma atrial natriuretic peptide concentration also fell significantly [20.1 (16.3–24.9)to 13.1 (10.6–16.2) pmol/l, P <0.05]. 4. We...
Articles
Clin Sci (Lond) (1989) 76 (5): 553-557.
Published: 01 May 1989
.... 22 8 1988 4 10 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 aldosterone diet exertion renin sodium restriction Clinical Science ( 1989) 76,553-557 553 Exercise tolerance in the heat on low and normal salt intakes M. HARGREAVES", T. 0. MORGAN", R...
Articles
Clin Sci (Lond) (1987) 72 (3): 313-319.
Published: 01 March 1987
...A. Louise Sugden; James A. Straw; Barbara L. Bean 1. Blood pressure was measured after treatment with a high K + , a low Na + and a combined high K + /low Na + diet in young spontaneously hypertensive rats (SHR). 2. A high K + diet reduced blood pressure by approximately 10 mmHg during the...
Articles
Clin Sci (Lond) (1987) 72 (3): 343-350.
Published: 01 March 1987
... to a control group eating a low fibre diet throughout, or to one of two experimental groups eating a high fibre diet for one of two 6-week experimental periods. Changes in body weight, other dietary constituents and lifestyle factors were avoided as far as possible. 2. Twenty-four hour diet records...
Articles
Clin Sci (Lond) (1986) 71 (1): 125-128.
Published: 01 July 1986
...Gordon T. McInnes; Josue G. Flores; John R. Shelton; Ian R. Harrison; Richard M. Perkins; Joan M. Clarke 1. Normal diet and a simple short term prescribed diet were compared with respect to mean excretion of urine electrolytes and the variability in these responses in 12 healthy male subjects...
Articles
Clin Sci (Lond) (1986) 70 (4): 395-398.
Published: 01 April 1986
... (established from measurements in 106 subjects). 2. After 34.5 kg mean weight loss, and during continued dieting, resting metabolic rate fell an average of 25% to 5.0 ± 0.18 kJ/min, significantly below that predicted for the new slimmed weight. 3. The fall in metabolic rate, over and above that expected from...
Articles
Clin Sci (Lond) (1985) 69 (6): 691-699.
Published: 01 December 1985
... hypertension. 2. Forty-eight rats were placed on either a 2-series prostaglandin ‘inhibitory’ diet (cod liver oil/linseed oil) or a control diet of saturated fat for an initial period of 4 weeks. The groups were then divided into two so that half of each received dexamethasone in their drinking water (2.5 mg/1...
Articles
Clin Sci (Lond) (1985) 69 (2): 165-175.
Published: 01 August 1985
... ratio (P/S ratio) diet (0.3) throughout, or to one of two experimental groups eating a high P/S ratio diet (1.0) for one of two 6-week experimental periods. Changes in other components were avoided. 2. Twenty-four hour diet records showed substantial changes in the P/S ratio for experimental groups when...
Articles
Clin Sci (Lond) (1985) 68 (4): 449-454.
Published: 01 April 1985
... membrane phospholipid pool. 19 10 1984 30 10 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 diet fatty acids (unsaturated) fish oil phospholipids platelet aggregation thromboxane Clinical Science (1985) 68, 449-454 449 Effects of dietary fish oil...
Articles
Clin Sci (Lond) (1983) 65 (3): 307-312.
Published: 01 September 1983
..., or (b) a group classified as ‘normal’ who have been selected for their high thermogenic capacity. 7 3 1983 24 3 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 diet glucose oxidation glucose tolerance obesity thermogenesis Clinical Science (1983...
Articles
Clin Sci (Lond) (1983) 64 (1): 19-23.
Published: 01 January 1983
...N. J. Rothwell; M. J. Stock © 1983 The Biochemical Society and the Medical Research Society 1983 brown adipose tissue diet energy balance sympathetic activity thermogenesis Clinical Science (1983) 64,19-23 19 CONTR 0 VERSIES IN MEDICINE Luxuskonsumption, diet-induced thermogenesis...
Articles
Clin Sci (Lond) (1983) 64 (1): 91-99.
Published: 01 January 1983
... Research Society 1983 diet essential fatty acids prostaglandins haemostasis high-density-lipoprotein cholesterol platelet function platelets triglycerides Clinical Science (1983) 64,91-99 91 The influence of different types of a13 polyunsaturated fatty acids on blood lipids and platelet...
Articles
Clin Sci (Lond) (1982) 63 (s8): 231s-234s.
Published: 01 October 1982
... pressure was measured after 1 min (casual) and after 5 min (baseline) of rest and during handgrip. 2. Moderate sodium restriction (from 170 to 100 mmol of sodium/day) decreased both intralymphocytic sodium content and diastolic blood pressure at rest and during handgrip. During a high potassium diet (130...
Articles
Clin Sci (Lond) (1981) 61 (3): 317-324.
Published: 01 September 1981
... period of supplementation and remained so 5 weeks after withdrawal of the supplement. No significant changes in other variables were noted. 29 1 1981 16 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 antithrombin III clotting factors diet...
Articles
Clin Sci (Lond) (1981) 61 (2): 129-133.
Published: 01 August 1981
...D. N. Brindley © 1981 The Biochemical Society and the Medical Research Society 1981 atherosclerosis diabetes diet ethanol fatty liver fructose glucocorticoids insulin lipid metabolism lipoprotein lipase lipoproteins obesity l-α-phosphatidate phosphohydrolase sorbitol stress...
Articles
Clin Sci (Lond) (1981) 60 (5): 519-525.
Published: 01 May 1981
... excess of the lean group so additional thermogenic defects must exist for familial obesity to be explained solely on a metabolic basis. 12 6 1980 25 11 1980 23 12 1980 © 1981 The Biochemical Society and the Medical Research Society 1981 diet obesity thermogenesis Clinical...
Articles
Clin Sci (Lond) (1981) 60 (4): 411-418.
Published: 01 April 1981
...A. M. Finch; G. P. Kasidas; G. A. Rose 1. Urinary composition was studied in nine healthy adults on unrestricted diet and low-oxalate diet with and without individual oxalate-rich foods. 2. Urine oxalate was constant on the low-oxalate and constant high-oxalate diets and only fluctuated greatly on...
Articles
Clin Sci (Lond) (1981) 60 (1): 81-86.
Published: 01 January 1981
... mg/day), fat-modified diet (mean polyunsaturated/saturated fat ratio of 1.0 with a mean of 43% of the total energy content derived from fat). 2. Before dietary manipulation, triglyceride levels in all lipoprotein fractions were significantly higher ( P < 0.02) than in a control group of age and...
Articles
Clin Sci (Lond) (1980) 59 (6): 509-511.
Published: 01 December 1980
...M. Elia; A. Carter; S. Bacon; R. Smith 1. To establish whether 3-methylhistidine in food is quantitatively excreted in the urine, five normal adults on a vegetarian diet were given known amounts of 3-methylhistidine in meat or fish. The mean cumulative 5-day increment in 3-methylhistidine excretion...
Articles
Clin Sci Mol Med (1978) 54 (3): 291-294.
Published: 01 March 1978
...A. Hodgkinson 1. The possible roles of the diet and of intestinal absorption in the increased excretion of oxalate by patients with renal calcium stones have been studied. 2. Dietary surveys showed that the mean daily intake of oxalic acid by stone-formers was not significantly different from that...
Articles
Clin Sci Mol Med (1973) 45 (s1): 99s-102s.
Published: 01 August 1973
...Hideo Ueda 1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR). 2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar. 3. Heart weight is increased in proportion to the elevation...
Articles
Clin Sci Mol Med (1973) 45 (s1): 103s-105s.
Published: 01 August 1973
...Takeshi Kimura 1. Epidemiological studies in Iwate, Northern Japan, have confirmed a higher incidence of cerebrovascular accidents and a lower incidence of ischaemic heart diseases in Japan than in North America and Western Europe. 2. The average daily diet in Iwate is relatively low in animal...