...L. S. Ibels; A. C. Alfrey 1. The effects of acute uraemia on arterial and visceral calcium concentrations were studied in acutely uraemic rats. The influences of thyroparathyroidectomy, phosphate depletion and diphosphonate therapy on extra-osseous calcium concentrations were assessed in this model...

...U. Trechsel; C. M. Taylor; J. A. Eisman; J.-P. Bonjour; H. Fleisch 1. Protein-binding assays have been used to measure plasma 1,25-dihydroxy-vitamin D [1,25-(OH) 2 D] as well as 25-hydroxy-vitamin D [25-(OH)D] in rats given 10 mg of phosphorus (P) day −1 kg −1 as ethane-1-hydroxy-1,1-diphosphonate...

...R. C. Mühlbauer; J.-P. Bonjour; H. Fleisch 1. Previous studies have shown that in thyroparathyroidectomized rats injection of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) at doses that inhibit bone mineral retention (0.16 mmol = 10 mg of phosphorus/kg body wt. per day subcutaneously) leads...

...Jennifer J. Pointon; M. J. O. Francis; R. Smith 1. Weanling rabbits were made rachitic either by a vitamin D-deficient diet or by parenteral administration of ethane 1-hydroxy-1,1-diphosphonate (EHDP) in amounts sufficient in other species to block the formation of 1,25-dihydroxycholecalciferol...

...Ailsa Goulding; M. F. Broom 1. The effects of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and colchicine on acid-base balance were examined in intact and nephrectomized rats. 2. Both drugs increased extracellular hydrogen ion concentrations and depressed extracellular bicarbonate...

...J. M. Baumann; S. Bisza; H. Fleisch; M. Wacker 1. The short- and longer-term effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP), an inhibitor of crystal growth and potential preventive agent against urinary tract stones in man, have been studied. 2. Measurement of urinary excretion of EHDP...