... is not well known. We hypothesized that ET-1 inhibits NO-mediated vasodilation via increased ADMA production in CHF, and that an endothelin receptor antagonist can prevent this increase in plasma ADMA levels. In the present study, we first examined whether circulating ADMA levels were increased in a dog model...

... mesenteric artery was performed for 30min in two groups of dogs. Declamping was followed by 90min of reperfusion. Mesenteric release of ET-1 was studied in series 1 ( n = 6). In series 2, 5min before cross-clamping, the treated group ( n = 7) received an intravenous bolus of LU135252 (5mg/kg), whereas...

...R. Fagard; E. Eyskens; H. Delooz; E. Fossion; A. Amery 1. A rapid fall in plasma renin concentration occurs not only in colonectomized but also in hepatectomized dogs after binephrectomy. 2. In the anhepatic anephric dog no renin extraction can be demonstrated across lungs, splanchnic region...