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Keywords: dopamine
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Clin Sci (Lond) (1996) 91 (2): 177–185.
Published: 01 August 1996
...-over study to investigate whether the administration of one amine precursor affects the renal metabolism of the other and to determine whether dopamine or 5-hydroxytryptamine would be generated preferentially. The overall effect on sodium excretion was also measured when both precursors were...
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Clin Sci (Lond) (1993) 84 (5): 549–557.
Published: 01 May 1993
... of dopamine in urine. Dopamine is natriuretic, and in rats, dietary salt loading increases renal dihydroxyphenylalanine uptake by increasing the rate of entry (spillover) of dihydroxyphenylalanine into arterial plasma. In experimental animals and in humans, dietary salt loading increases urinary excretion...
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Clin Sci (Lond) (1993) 84 (4): 357–375.
Published: 01 April 1993
...M. R. Lee Ten years ago the Editorial Board of Clinical Science invited me to write an Editorial Review on dopamine and the kidney. The result was published in 1982 in Volume 62 [1]. It was my hope that it would serve to stimulate other investigators to take up this area of renal physiology...
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Clin Sci (Lond) (1991) 80 (2): 149–154.
Published: 01 February 1991
...D. W. Eadington; C. P. Swainson; M. R. Lee 1. The effect of inhibition of intrarenal dopamine synthesis by carbidopa on the renal response to angiotensin II infusion was studied in six healthy salt-loaded volunteers. 2. Subjects received an infusion of angiotensin II at two doses (0.5 and 1.0 ng...
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Clin Sci (Lond) (1990) 78 (5): 503–507.
Published: 01 May 1990
...) and sodium clearance ( C Na ), renal function and the tubular segmental reabsorption rates of sodium and water during dopamine infusion (3 μg min −1 kg −1 ) were estimated in 12 normal volunteers. 2. C Na increased by 128% ( P <0.001). Effective renal plasma flow and GFR increased by 43% ( P <0.001...
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Clin Sci (Lond) (1990) 78 (4): 423–429.
Published: 01 April 1990
...Ehud Grossman; Aaron Hoffman; Peter C. Chang; Harry R. Keiser; David S. Goldstein 1. We measured urinary excretion rates of dopamine (3,4-dihydroxyphenethylamine) and dopa (3,4-dihydroxyphenylalanine) and the spillover rate of dopa into arterial blood during dietary salt loading in conscious Dahl...
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Clin Sci (Lond) (1989) 77 (3): 281–285.
Published: 01 September 1989
...Helen M. Lewis; M. R. Wilkins; M. J. Kendall; M. R. Lee 1. The dependence of atrial natriuretic factor on renal dopamine for its renal effects in man was examined in 10 healthy volunteers using the dopa decarboxylase inhibitor carbidopa. 2. Each volunteer attended on two occasions, and received...
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Clin Sci (Lond) (1988) 75 (5): 515–520.
Published: 01 November 1988
...Reuven Zimlichman; Paul D. Levinson; Gerald Kelly; Robin Stull; Harry R. Keiser; David S. Goldstein 1. We estimated the extent to which circulating dopa (3,4-dihydroxyphenylalanine) is the source of urinary dopamine (DA; 3,4-dihydroxyphenethylamine). Tritiated dopa ([ 3 H]dopa) was infused for 90...
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Clin Sci (Lond) (1988) 75 (5): 503–507.
Published: 01 November 1988
... acids l -dopa ( l -3,4-dihydroxyphenylalanine) and 5-hydroxytryptophan. During the final two clearance periods, the peripheral decarboxylase inhibitor, carbidopa ( S -α-hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid monohydrate), was infused additionally. 2. Renal formation of dopamine (3,4...
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Clin Sci (Lond) (1988) 74 (2): 137–143.
Published: 01 February 1988
... enhance renal sodium retention. 13 5 1987 30 7 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 aldosterone cirrhosis dopamine metoclopramide prolactin renal function renin Clinical Science ( 1988) 74. 137- 143 137 Unaltered dopaminergic modulation...
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Clin Sci (Lond) (1987) 73 (1): 93–97.
Published: 01 July 1987
...G. C. Inglis; C. J. Kenyon; J. A. M. Hannah; J. M. C. Connell; S. G. Ball 1. This study investigated the role of dopamine in the control of adrenal steroidogenesis. Adrenaline, noradrenaline and dopamine have been measured in plasma and in the adrenal zona glomerulosa and medulla of rats fed low...
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Clin Sci (Lond) (1987) 72 (5): 621–627.
Published: 01 May 1987
...P. E. Harris; B. M. Lewis; C. Dieguez; R. Hall; M. F. Scanlon 1. The effects of hypothyroidism in utero , and continuing into postnatal life, on the central turnover of catecholamines, noradrenaline and dopamine were studied in rats. 2. Rats were rendered hypothyroid in utero by treating pregnant...
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Clin Sci (Lond) (1987) 72 (3): 277–282.
Published: 01 March 1987
... acting dopamine antagonist metoclopramide (10 mg intravenously) in the hyperprolactinaemic patients as compared with the controls. 3. Prolactin responsiveness to metoclopramide was reduced in the patients as compared with the controls, such being considered characteristic of a prolactinoma. 4. Basal...
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Clin Sci (Lond) (1985) 69 (2): 207–214.
Published: 01 August 1985
... rose at both doses, but mean glomerular filtration rate increased only at the lower dose. 4. There was a fall in mean plasma renin activity after the infusion of both 12.5 and 100 μg min −1 kg −1 . 5. Mean urine free dopamine excretion increased by 280- and 2500-fold at infusion rates of 12.5 and 100...
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Clin Sci (Lond) (1985) 68 (3): 263–269.
Published: 01 March 1985
... in an increase in renal excretion of dopamine (3,4-dihydroxy-phenylethylamine) and a decrease in renal excretion of noradrenaline. 4. Carbidopa treatment decreased urinary sodium excretion and eliminated the increase in renal production of dopamine in response to saline infusion without affecting renal...
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Clin Sci (Lond) (1984) 67 (2): 219–223.
Published: 01 August 1984
...J. M. C. Connell; S. G. Ball; G. C. Inglis; G. H. Beastall; D. L. Davies 1. The effect of low-dose dopamine infusion on anterior pituitary hormone secretion in a group of seven healthy female subjects is reported. Subjects were infused with NaCl solution (154 mmol/l) (control) or dopamine (0.01...
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Clin Sci (Lond) (1982) 63 (s8): 297s–299s.
Published: 01 October 1982
...S. G. Ball; I. G. Gunn; K. J. D. Macarthur; I. H. S. Douglas; G. C. Inglis 1. Plasma levels of dopa, dopamine, noradrenaline and adrenaline were measured in blood sampled from the renal vein and from the aorta at the origin of the renal artery in six anaesthetized greyhound dogs. 2. Plasma levels...
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Clin Sci (Lond) (1982) 63 (1): 93–96.
Published: 01 July 1982
...L. F. O. Obika; E. G. Schneider 1. The influence of dietary sodium intake on the pressor response to intravenously infused dopamine in the conscious rat was studied. 2. Chronic sodium restriction significantly reduced the pressor response to infused dopamine, whereas high sodium diet enhanced...
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Clin Sci (Lond) (1982) 62 (5): 439–448.
Published: 01 May 1982
...M. R. Lee © 1982 The Biochemical Society and the Medical Research Society 1982 dopamine hypertension kidney renin sodium CIfnfcal Science (1982) 62,439448 439 EDITORIAL REVIEW Dopamine and the kidney M. R. LEE Department of Medicine, Martin Wing, Leeds General I@rmary, Leeds, U.K...
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Clin Sci (Lond) (1982) 62 (2): 209–213.
Published: 01 February 1982
...H.-G. Güllner; D. J. Lakatua; F. C. Bartter 1. The effect of inhibition of prostaglandin synthesis on urinary excretion of free dopamine, a catecholamine thought to act as a renal natriuretic hormone, was examined in six normal women. 2. The volunteer subjects were treated with indomethacin (2 mg...
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Clin Sci (Lond) (1981) 61 (4): 423–428.
Published: 01 October 1981
...C. M. Perkins; K. W. Hancock; G. F. Cope; M. R. Lee 1. Urine free dopamine was estimated at predetermined points of the menstrual cycle in normal volunteer subjects and in women taking a combined oral contraceptive. 2. There was no alteration in 24 h urine dopamine during the normal menstrual cycle...
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Clin Sci (Lond) (1980) 59 (s6): 171s–173s.
Published: 01 December 1980
... loading. 3. Salt loading caused a distinct increase in plasma noradrenaline concentration in spSH rats, but a slight decrease in WK rats. Plasma adrenaline and dopamine concentrations remained unaffected. 4. Exposure to cold resulted in a more marked stimulation of sympathoadrenal and sympathoneuronal...
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Clin Sci (Lond) (1980) 59 (s6): 79s–82s.
Published: 01 December 1980
...J. S. Hutchinson; A. E. Doyle 1. Neurosecretion of peptides from superfused neurohypophyses in vitro was inhibited by dopamine. 2. This inhibition was dose-dependent. 3. Intravenous injection of the dopamine agonist, bromocriptine, lowered blood pressure in spontaneously hypertensive rats within 15...
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Clin Sci (Lond) (1980) 58 (1): 77–82.
Published: 01 January 1980
...N. S. Oates; C. M. Perkins; M. R. Lee 1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0·2...
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Clin Sci (Lond) (1979) 56 (3): 261–264.
Published: 01 March 1979
...N. S. Oates; S. G. Ball; C. M. Perkins; M. R. Lee 1. Plasma and urine free dopamine were measured daily for 5 days in six normal subjects maintained on a low sodium diet. The subjects were then given dietary supplements of sodium chloride for 5 days and the measurements repeated. 2. Throughout...
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Clin Sci Mol Med (1978) 55 (2): 167–173.
Published: 01 August 1978
...S. G. Ball; N. S. Oats; M. R. Lee 1. Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man were greater than could...
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Clin Sci Mol Med (1977) 53 (4): 303–306.
Published: 01 October 1977
...J. L. Reid CIinical Science and Molecular Medicine (1977) 53, 303-306. EDITORIAL REVIEW Dopaminergic pathways and their pathophysiological significance J . L. REID Department of Clinical Pharmacology, Royal Postgraduate Medical School, London Key words: behaviour, dopamine, motor system...
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Clin Sci Mol Med (1976) 51 (s3): 415s–421s.
Published: 01 December 1976
...J. Axelrod © 1976 The Biochemical Society and the Medical Research Society 1976 adrenaline catecholamines dopamine noradrenaline Cllnical Science and Molecular Medicine (1976) 51, 4 1 5 ~ 4 2 1 s . RE VIEW Catecholamines and hyper tension J. A X E L R O D Section on Pharmacology...
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Clin Sci Mol Med (1975) 48 (4): 327–330.
Published: 01 April 1975
... with deoxycorticosterone. 3. Intact rats restricted to the equivalent con- sumption of saline of rats pretreated with 6-hydroxy- dopamine develop hypertension despite this restric- tion. 4. It is suggested that the prevention of deoxy- corticosterone hypertension by central 6-hydroxy- dopamine does not depend on reduced...
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