...Horst Grobecker; Juan Saavedra; Virginia Weise 1. There was a significant decrease in the activity of tryosine hydroxylase, dopamine-β-hydroxylase and phenylethanolamine- N -methyltransferase in young spontaneously hypertensive rats (SHR) at the age of 2 and 4 weeks, compared with the activity...

... methods we compared strains for the time of appearance and maturation of the enzymes tyrosine hydroylase (TH), dopamine-β-hydroxylase (DBH) and phenylethanolamine- N -methyltransferase (PNMT) in sympathetic ganglia and adrenals. 3. The time of appearance of enzymes was identical in all three strains: TH...

... after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine β-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks. 4. Enhanced hypothalamic noradrenaline synthesis may be a pathogenic factor in Goldblatt I renovascular hypertension...

... of both noradrenaline and dopamine-β-hydroxylase activity were increased compared with those of normotensive rats of the Wistar/Kyoto strain. Total catecholamines (mostly adrenaline) were not significantly different. 3. In the adrenal glands of 2-weeks-old and 4-weeks-old SHR activities of tyrosine...

... activity. 2. Prediction of its anti-hypertensive effect is better based on the evaluation of the sympathetic nervous system responsiveness to head-up tilt than on the evaluation of plasma renin activity or dopamine-β-hydroxylase. 3. The anti-hypertensive effect of acebutolol is better explained...