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Keywords: drug discovery
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Clin Sci (Lond) (2018) 132 (21): 2323–2338.
Published: 02 November 2018
... subtype 5 (mGlu 5 ) has emerged as a promising target for a broad range of psychiatric and neurological disorders. Drug discovery programs targetting mGlu 5 are primarily focused on development of allosteric modulators that interact with sites distinct from the endogenous agonist glutamate. Significant...
Articles
Clin Sci (Lond) (2017) 131 (9): 799–802.
Published: 19 April 2017
.... Correspondence: Paul B. Wren ( [email protected] ) 7 12 2016 6 2 2017 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 Alzheimer's disease cerebrovascular disease dementia drug discovery translational science...
Articles
Clin Sci (Lond) (2000) 99 (4): 255–260.
Published: 06 September 2000
... in over 100 countries and more than 150 million tablets have been dispensed worldwide. The sildenafil research programme reflects a traditional approach to drug discovery, but pressures to improve productivity have prompted major investments in genome sciences and new technologies. The impact...