... −/− mice. The aortic media in most of the dilated area was thickened. In regions of medial thickening, distinct elastin layers were discernable. There was an expansion of the distance between elastin layers in a gradient from the intimal to the adventitial aspect of the media. This pathology differed...

...-protein or high-fat diet. At 12 weeks, the offspring rats were killed. In 46 rats, aortic sections were mounted and stained to assess media thickness and elastin content. In a further 38 rats, aortic rings were suspended in an organ bath and vascular reactivity was tested with dose–response curves...

...Patrick LACOLLEY; Pierre BOUTOUYRIE; Marina GLUKHOVA; Jean-Marie DANIEL LAMAZIERE; Pierre-François PLOUIN; Patrick BRUNEVAL; Phat VUONG; Pierre CORVOL; Stéphane LAURENT Although the aetiology of Williams syndrome (WS) is related to elastin gene disruption, its pathogenesis remains unknown...

... leucocyte elastase activity towards insoluble human lung elastin, as determined by an e.l.i.s.a. for soluble elastin-derived peptides released by elastolytic activity on the elastin. This inhibition was shown not to be due to a direct interference of the glycosaminoglycans in the e.l.i.s.a. nor...

... in aneurysm patients (0.15 versus 0.05 in control subjects, P < 0.01). These two genetic markers appear to act independently. Haptoglobins containing an α 1 -chain accelerated two-to fourfold the degradation by elastases of aortic elastin in vitro . 3. Genetic variation in the haptoglobin and cholesterol...

.... 1 12 1987 22 12 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 antileucoprotease elastase elastin emphysema myeloperoxidase polymorphonuclear leucocytes Clinical Science (1988) 75,53-62 53 Interactions among stimulated human polymorphonuclear...