... in therapeutic strategies targeting these two pathways. One principal alteration associated with age-related changes of the cardiovascular system is an elevation in vascular tone [ 1 , 2 ], which probably contributes to the attenuated skeletal muscle blood flow commonly observed in the elderly [ 3 – 8...

... stratification in elderly patients with HF (heart failure) with depressed or preserved ventricular function has not been evaluated. In the present study, we analysed whether CPET is useful in predicting outcome in this population. A total of 220 NYHA (New York Heart Association) class I–III patients with HF ≥70...

... pathways could contribute to the development of age-related cardiovascular disease. Correspondence: Dr N. Singh (e-mail [email protected] ). 7 9 2001 13 11 2001 13 2 2001 The Biochemical Society and the Medical Research Society © 2002 2002 elderly endothelium...

... diseases account for considerable morbidity and almost half of all deaths in people over the age of 75 years. 2. We have therefore compared nitric oxide-dependent vasorelaxation in 12 healthy elderly subjects with 12 young volunteers matched for blood pressure, cholesterol and glucose, using forearm...

... control and the feasibility of physical training in the elderly. 2. A total of 58 patients (mean age: 62 ± 5 years; range: 55–75 years) with type 2 diabetes were randomized to either a physical training or a control programme. The training programme consisted of three sessions a week, aiming at 60–80...

...M. A. James; M. D. Fotherby; J. F. Potter 1. Microalbumuria in non-diabetic elderly subjects is predictive of vascular disease and mortality, and related to levels of blood pressure. 2. This study was designed to examine whether more restricted periods of urine collection retained the relation...

...M. B. Sidery; A. J. Cowley; I. A. MacDonald 1. The cardiovascular responses to high-fat and high-carbohydrate meals (2.5 MJ) were compared in healthy, non-obese elderly subjects (mean age 68 years, range 63–74 years). 2. Measurements of cardiac output, blood pressure, heart rate, calf blood flow...

... reduced in the elderly group, although individual responses varied from normal to absent, and they also had a considerably greater variability as measured on three separate occasions than seen in young subjects. Discriminant analysis showed that, from each of three occasions, 65% of vasoconstrictor...

.... T. Ohm; W. Pelemans; A. I. Suchett-Kaye; J. Tuomilehto; J. Willems; P. Willemse 1. A total of 450 hypertensive patients above the age of 60 years have entered the double-blind multicentre trial of the European Working Party on High blood pressure in Elderly (EWPHE). After stratification...

... of blood pressure are a serious problem, particularly in the elderly. Direct intra-arterial measurement may be useful in the management of hypertension. © 1978 The Biochemical Society and the Medical Research Society 1978 direct elderly hypertension indirect measurement pressure...