... (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b + /CD11c + ), and CD8 + T cells, and progression of emphysema. In the present study, we examined the mechanisms underlying...

... cigarette smoke, causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T-cells are prominent, leads to oxidative stress, emphysema, small airways fibrosis and mucus hypersecretion. The mechanisms and mediators that drive the induction and progression of chronic...

... is associated with increased serum erythropoietin levels both by day and by night. © 1993 The Biochemical Society and the Medical Research Society 1993 circadian rhythm chronic bronchitis emphysema erythropoietin hypoxaemia polycythaemia Clinical Science (1993) 84, 319-324 (Printed in Great...

...%, respectively. 4. In vivo , the inhibitory effects of intratracheally administered rALP242 and rALP231 towards human-neutrophil-elastase-induced emphysema were significantly greater than that of recombinant antileucoprotease. There were no significant differences between the mutants. With respect to secretory...

...M. Gugger; G. Gould; M. F. Sudlow; P. K. Wraith; W. MaCnee 1. We assessed lung density, determined by computerized tomography, as a measure of emphysema and related this to lung function and measurement of the elastic recoil of the lung in normal subjects and patients with chronic obstructive lung...

...David Burnett; Anita Chamba; Susan L. Hill; Robert A. Stockley 1. Neutrophils from patients with chronic obstructive bronchitis and emphysema or age-matched control subjects were cultured on a substrate of 125 I-fibronectin. The neutrophils from patients with lung disease digested significantly...

... patients with emphysema and in 11 healthy controls. Whole-body protein turnover was measured using l -[1- 13 C]leucine. 2. Leg efflux of tyrosine was increased by 47% in emphysematous patients compared with normal control subjects, but 3-methylhistidine efflux was not significantly altered. 3. In emphysema...

.... 1 12 1987 22 12 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 antileucoprotease elastase elastin emphysema myeloperoxidase polymorphonuclear leucocytes Clinical Science (1988) 75,53-62 53 Interactions among stimulated human polymorphonuclear...

...H. M. Morrison; J. A. Kramps; S. C. Afford; D. Burnett; J. H. Dijkman; R. A. Stockley 1. Anti-elastase function in sputum sol-phase from patients with α 1 -proteinase inhibitor (α 1 PI) deficiency was compared with sol-phase from patients with cigarette smoke-induced bronchitis and emphysema. 2...

...A. P. Greening; D. B. Lowrie 1. It has been suggested that oxidants from pulmonary inflammatory cells may contribute to the development of emphysema by (i) direct tissue toxicity and (ii) inhibition of α 1 -antitrypsin, thus diminishing protection of the lung from proteolytic damage. 2...

...G. W. Bradley; T. Hale; J. Pimble; R. Rowlandson; M. I. M. Noble 1. The potential value of right vagotomy for the relief of breathlessness has been explored in five patients with emphysema. Two patients had symptomatic improvement, two had minor symptomatic improvement, and one was unchanged. 2...

...% of normal (331 ± 110 ml). There was therefore no correlation between the amount of emphysema and the reduction in pulmonary blood volume. CIinical Science and Molecular Medicine (1977) 53,587-593. Pulmonary blood volume in chronic bronchitis B. RAFFESTIN, H. VALETTE, J. L. HEBERT, P. DUHAZE AND A. LOCKHART...