... tissue distribution of the ET system, its up-regulation in pathological situations and a local autocrine/paracrine activity due to a high tissue receptor binding, make the tissue ET system a key local player in end-organ damage. Furthermore, ET-1 interacts in tissues with other systems such as the RAAS...

... changes evaluated by carotid intima media thickness. Sustained HTN eventually leads to end-organ damage [LVH (left ventricular hypertrophy), central nervous system], which in turn increases the risk of cardiovascular morbidity and mortality. New developments in childhood HTN, as outlined in the present...

... target organ damage. The present studies were performed in Ren-2 renin transgenic rats (TGR) to evaluate the effects of chronic selective inhibition of 20-HETE formation or elevation of the level of EETs, alone or in combination, on the course of hypertension and hypertension-associated end-organ damage...

... endothelin endothelin receptor end-organ damage 17β-oestradiol sex testosterone According to the Department of Reproductive Health and Research, World Health Organization (WHO Draft working definition, October 2002; http://www.who.int/reproductive-health/gender/glossary.html ), “sex refers...

... A. Shagdarsuren E. Rong S. Aldosterone synthase inhibitor FAD286 ameliorates angiotensin II-induced end-organ damage Hypertension 2004 44 514 515 41 Luther J. M. Gainer J. V. Murphey L. J. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor...