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1-12 of 12
Keywords: endoplasmic reticulum
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Articles
Allan D. Sniderman, Jacqueline De Graaf, Patrick Couture, Ken Williams, Robert S. Kiss, Gerald F. Watts
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (5): 333–339.
Published: 23 November 2009
... the cell or to sites within the cell such as the ER (endoplasmic reticulum) and the mitochondria. This sets off a broad set of regulatory responses. Sequestration of SREBP (sterol-regulatory-element-binding protein) within the ER results in down-regulation of cholesterol and LDL receptor synthesis. An even...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (1): 19–29.
Published: 28 September 2009
...Toru Hosoi; Koichiro Ozawa Various stresses, which impair ER (endoplasmic reticulum) function, lead to an accumulation of unfolded or misfolded proteins. ER stress triggers many rescuer responses, including a UPR (unfolded protein response). Increasing evidence has suggested that ER stress...
Articles
Ugo I. Ekeowa, Bibek Gooptu, Didier Belorgey, Peter Hägglöf, Susanna Karlsson-Li, Elena Miranda, Juan Pérez, Ian MacLeod, Heike Kroger, Stefan J. Marciniak, Damian C. Crowther, David A. Lomas
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (12): 837–850.
Published: 14 May 2009
... (email [email protected] ). 22 9 2008 13 11 2008 28 11 2008 α 1 -antitrypsin chronic obstructive pulmonary disease (COPD) endoplasmic reticulum proteolytic cascade serine protease inhibitor serpinopathy α 1 -Antitrypsin is a 394-amino-acid acute-phase serine protease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... -acetyl-d-glucosaminidase), endoplasmic reticulum (neutral α-d-glucosidase) and cytosol (lactate dehydrogenase). 4. This technique can be used to investigate disease of the human rectum at a subcellular level. 10 6 1980 29 7 1980 © 1980 The Biochemical Society and the Medical Research...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (1): 7–12.
Published: 01 July 1980
... acid α-d-glucosidase was noted but there was also increased activity of neutral α-d-glucosidase (found in endoplasmic reticulum). 3. Activities of the acid hydrolases, acid phosphatase and β- N -acetyl-d-glucosaminidase, were elevated compared with those of controls. Measurement of latent β- N -acetyl...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (1): 1–6.
Published: 01 July 1980
... ((β- N -acetyl-d-glucosaminidase), endoplasmic reticulum (neutral α - glucosidase), cytosol (lactate dehydrogenase). 4. This technique can be applied to investigate disease of the gastric antrum at a subcellular level. 22 11 1979 27 2 1980 © 1980 The Biochemical Society...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 57 (6): 491–497.
Published: 01 December 1979
... reticulum marker enzyme, neutral α-glucosidase. Seven patients showed a decrease in the modal density of the endoplasmic reticulum, from 1·20 to 1·15 g/ml. These patients also showed striking hypertrophy of the hepatocyte smooth endoplasmic reticulum on electron microscopy. The remaining five patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (5): 479–486.
Published: 01 May 1979
... 8 1978 15 12 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 basal—lateral membrane brush borders cytosol endoplasmic reticulum enzymes giardiasis lysosomes mitochondria subcellular fractionation tropical malabsorption Clinical Science (1979...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 55 (3): 285–292.
Published: 01 September 1978
... activities of both mitochondrial and cytosol malate dehydrogenase, with increased activities of cytosol lactate dehydrogenase. 6. The endoplasmic reticulum and basal-lateral membranes were relatively unaffected except that the equilibrium densities were slightly increased and decreased respectively. 7...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (1): 63–74.
Published: 01 July 1977
... 2+ -dependent adenosine triphosphatase showed dual localization to the mitochondria and to the sarcolemma. 8 11 1976 25 2 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 adenosine triphosphatases endoplasmic reticulum lysosomes microsomes...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (4): 429–442.
Published: 01 April 1977
... and glutathione peroxidase were localized predominantly to the cytosol. 7. Neutral α-glucosidase and γ-glutamyl transpeptidase showed a bimodal distribution with localizations to both endoplasmic reticulum and specific granule components. 8. It is suggested that the plasma membrane, and thus the wall of phagocyte...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (6): 557–574.
Published: 01 December 1976
... densities in sucrose density gradients: brush borders (1·21), peroxisomes (1·18), mitochondria (1·16), endoplasmic reticulum (1·16), basal—lateral membranes (1·12). At least three distinct populations of lysosomes with different modal densities and enzyme content were demonstrated. 5. This analytical...